Zinc finger FYVE domain-containing protein 1 is a protein that in humans is encoded by the ZFYVE1 gene.[5][6][7]

ZFYVE1
Identifiers
AliasesZFYVE1, DFCP1, PPP1R172, SR3, TAFF1, ZNFN2A1, zinc finger FYVE-type containing 1
External IDsOMIM: 605471; MGI: 3026685; HomoloGene: 10945; GeneCards: ZFYVE1; OMA:ZFYVE1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001281734
NM_001281735
NM_021260
NM_178441

NM_183154
NM_001359166
NM_001359167
NM_001359168

RefSeq (protein)

NP_001268663
NP_001268664
NP_067083
NP_848535

NP_898977
NP_001346095
NP_001346096
NP_001346097

Location (UCSC)Chr 14: 72.97 – 73.03 MbChr 12: 83.59 – 83.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution. Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.[7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165861Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042628Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Derubeis AR, Young MF, Jia L, Robey PG, Fisher LW (Nov 2000). "Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library". Gene. 255 (2): 195–203. doi:10.1016/S0378-1119(00)00303-6. PMID 11024279.
  6. ^ Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM (Mar 2001). "Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi". Biochem J. 355 (Pt 1): 113–21. doi:10.1042/0264-6021:3550113. PMC 1221718. PMID 11256955.
  7. ^ a b "Entrez Gene: ZFYVE1 zinc finger, FYVE domain containing 1".

Further reading

edit