Zinc finger protein ZFPM1

Zinc finger protein ZFPM1 also known as friend of GATA protein 1 (FOG-1) is a protein that in humans is encoded by the ZFPM1 gene. It is a cofactor of the GATA1 transcription factor.

ZFPM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XU7
Identifiers
Aliases	ZFPM1, FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A, zinc finger protein, FOG family member 1
External IDs	OMIM: 601950 MGI: 1095400 HomoloGene: 7606 GeneCards: ZFPM1
Gene location (Human) Chr. Chromosome 16 (human) Band 16q24.2 Start 88,453,280 bp End 88,537,031 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E1 Start 123,008,880 bp End 123,063,990 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell pylorus cardia parotid gland ventral tegmental area subthalamic nucleus external globus pallidus vena cava jejunal mucosa upper arm Top expressed in left lobe of liver epithelium of stomach pyloric antrum internal carotid artery external carotid artery spleen duodenum atrium crypt of lieberkuhn of small intestine bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription factor binding metal ion binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm transcription regulator complex transcription repressor complex nucleoplasm nucleus Biological process megakaryocyte development megakaryocyte differentiation negative regulation of mast cell differentiation negative regulation of fat cell differentiation regulation of transcription, DNA-templated homeostasis of number of cells ventricular septum morphogenesis outflow tract morphogenesis platelet formation blood coagulation cardiac muscle tissue morphogenesis negative regulation of transcription by RNA polymerase II negative regulation of protein binding transcription, DNA-templated regulation of chemokine production atrial septum morphogenesis heart development atrioventricular valve morphogenesis granulocyte differentiation embryonic hemopoiesis regulation of definitive erythrocyte differentiation T-helper cell lineage commitment primitive erythrocyte differentiation mitral valve formation tricuspid valve formation definitive erythrocyte differentiation positive regulation of transcription by RNA polymerase II erythrocyte differentiation regulation of megakaryocyte differentiation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 161882 22761 Ensembl ENSG00000179588 ENSMUSG00000049577 UniProt Q8IX07 O35615 RefSeq (mRNA) NM_153813 NM_009569 RefSeq (protein) NP_722520 NP_033595 Location (UCSC) Chr 16: 88.45 – 88.54 Mb Chr 8: 123.01 – 123.06 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Tsang AP, Visvader JE, Turner CA, et al. (1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation". Cell. 90 (1): 109–19. doi:10.1016/S0092-8674(00)80318-9. PMID 9230307. S2CID 2085524.
• Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
• Mehaffey MG, Newton AL, Gandhi MJ, et al. (2001). "X-linked thrombocytopenia caused by a novel mutation of GATA-1". Blood. 98 (9): 2681–8. doi:10.1182/blood.V98.9.2681. PMID 11675338.
• Yu C, Niakan KK, Matsushita M, et al. (2002). "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction". Blood. 100 (6): 2040–5. doi:10.1182/blood-2002-02-0387. PMC 2808424. PMID 12200364.
• Freson K, Thys C, Wittewrongel C, et al. (2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions". Hum. Genet. 112 (1): 42–9. doi:10.1007/s00439-002-0832-1. PMID 12483298. S2CID 7394526.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Liew CK, Simpson RJ, Kwan AH, et al. (2005). "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction". Proc. Natl. Acad. Sci. U.S.A. 102 (3): 583–8. Bibcode:2005PNAS..102..583L. doi:10.1073/pnas.0407511102. PMC 545545. PMID 15644435.
• Vannucchi AM, Pancrazzi A, Guglielmelli P, et al. (2005). "Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis". Am. J. Pathol. 167 (3): 849–58. doi:10.1016/S0002-9440(10)62056-1. PMC 1698737. PMID 16127162.
• Yang HY, Kim SH, Kim SH, et al. (2007). "The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells". Biochem. Biophys. Res. Commun. 353 (4): 978–84. doi:10.1016/j.bbrc.2006.12.155. PMID 17207461.