Z5 may refer to:
- Harbin Z-5, Chinese helicopter
- Mazda Z engine
- a file extension used by Z-machine
- Z5 (computer) designed by Konrad Zuse
- the GMG Airlines IATA airline code
- German destroyer Z5 Paul Jakobi
- the Beijing-Nanning-Hanoi Through Train (southbound)
- Zbrojovka Z5 Express, a Czech car of the 1930s
- LNER Class Z5, a class of British steam locomotives
- Nikon Z 5 mirrorless camera
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