William Semple may refer to:
- William Semple (footballer) (1861–1940), Scottish footballer
- William F. Semple, American dentist, commonly referred to as the first person to patent a chewing gum
- Billy Semple (born 1946), Scottish footballer.
See also
edit- William Sempill, 2nd Lord Sempill, Scottish lord
This disambiguation page lists articles about people with the same name.
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