William Russo may refer to:
- William Daddano Sr. (1912–1975), also known as William Russo, American mobster
- William Russo (musician) (1928–2003), American jazz musician
- Bill Russo (American football), head college football coach
- Jigsaw (Marvel Comics), a villain from Marvel Comics, born William "Billy" Russo
This disambiguation page lists articles about people with the same name.
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