William Penn High School may refer to:
- William Penn High School (Delaware) in New Castle, Delaware
- William Penn High School (North Carolina), High Point, North Carolina
- William Penn High School (Philadelphia), Philadelphia, Pennsylvania
- William Penn High School in Harrisburg, Pennsylvania, a former school building; see Harrisburg High School
See also edit
- Penn High School, Mishawaka, Indiana
- William Penn School (disambiguation)
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