Wikipedia:Reference desk/Archives/Science/2023 April 24

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April 24

What is more epinephrine agonist, tricyclic antidepressants (such as Amitriptyline), or tetracyclic antidepressants (such as Mirtazapine)?

Thanks. 2A10:8012:15:C48E:4400:7673:DFF0:2D67 (talk) 02:18, 24 April 2023 (UTC)

I saw one article (PMC 5715313) that states: "The SSRIs and other atypical antidepressants (eg, trazadone, mirtazapine, bupropion) do not have significant epinephrine or ephedrine interactions (Figure 4)." In another article specifically about mirtazapine (PMID 30085601), epinephrine is not mentioned in a list of drugs known to interact with mirtazapine. I do not know if this can be generalized to tetracyclic antidepressants in general.  --Lambiam 05:58, 24 April 2023 (UTC)