Walker House, and variations including Walker Homestead and Walker Barn, may refer to:
- Walker House (Daphne, Alabama), listed on the National Register of Historic Places (NRHP) in Baldwin County, Alabama
- Joseph M. Walker House, Mobile, Alabama, listed on the NRHP in Mobile County
- Walker-Klinner Farm, Maplesville, Alabama, listed on the NRHP in Chilton County
- Walker-Broderick House, Ketchikan, Alaska, listed on the NRHP in Ketchikan Gateway Borough
- O. E. Walker House, Kingman, Arizona, listed on the NRHP in Mojave County, Arizona
- Harry Walker House, Tempe, Arizona, listed on the NRHP in Maricopa County, Arizona
- Walker House (Dermott, Arkansas), formerly listed on the National Register of Historic Places in Chicot County
- Walker House (Fayetteville, Arkansas), listed on the NRHP in Washington County
- Walker Homestead Historic District, Garner, Arkansas, listed on the NRHP in White County
- Thomas Walker House, Hardy, Arkansas, listed on the NRHP in Sharp County
- Evelyn Gill Walker House, in Paris, Arkansas, listed on the NRHP in Logan County
- Otha Walker Homestead, West Point, Arkansas, listed on the NRHP in White County
- Walker House, Oakland, California, opened by Yvette Flunder for services to people affected by HIV/AIDS
- Walker Ranch Historic District, Boulder, Colorado, listed on the NRHP in Boulder County
- Armstrong-Walker House, Middletown, Delaware, listed on the NRHP in New Castle County
- R. Walker Barn, Newark, Delaware, listed on the NRHP in New Castle County
- Galloway-Walker House, Newport, Delaware, listed on the NRHP in New Castle County
- Walker's Mill and Walker's Bank, Wilmington, Delaware, listed on the NRHP
- Horace Walker House, St. Augustine, Florida, listed on the NRHP in St. Johns County
- Harris-Pearson-Walker House, Augusta, Georgia, listed on the NRHP in Richmond County
- Walker-Peters-Langdon House, Columbus, Georgia, listed on the NRHP in Muscogee County
- Almand-O'Kelley-Walker House, Conyers, Georgia, listed on the NRHP in Rockdale County
- H. Alexander Walker Residence, Honolulu, Hawaii, listed on the NRHP on Oahu
- Madame C. J. Walker Building, Indianapolis, Indiana, listed on the NRHP in Marion County, Indiana
- James Walker House, Anchorage, Kentucky, listed on the NRHP in Anchorage
- E. W. Walker House, Hopkinsville, Kentucky, listed on the NRHP in Christian County
- Walker House (Lancaster, Kentucky), listed on the NRHP in Garrard County
- Hankla-Walker House, Perryville, Kentucky, listed on the NRHP in Boyle County
- William Walker House, Richmond, Kentucky, listed on the NRHP in Madison County
- Walker House (Richmond, Kentucky), listed on the National Register of Historic Places in Madison County
- Morgan Walker House, in Alexandria, Louisiana, listed on the NRHP in Rapides Parish
- Walker House (New Orleans, Louisiana), listed on the National Register of Historic Places in Orleans Parish
- Walker Memorial Hall, Bridgton, Maine, listed on the NRHP in Cumberland County
- Walker Memorial Library, Westbrook, Maine, listed on the NRHP in Cumberland County
- Walker-Collis House, Belchertown, Massachusetts, listed on the NRHP in Hampshire County
- Harding House-Walker Missionary Home, Newton, Massachusetts, listed on the NRHP in Middlesex County
- Walker Home for Missionary Children, Newton, Massachusetts, listed on the NRHP in Middlesex County
- Bogle-Walker House, Sudbury, Massachusetts, listed on the NRHP in Middlesex County
- Peter Walker House, Taunton, Massachusetts, listed on the NRHP in Bristol County
- Walker Tavern, Cambridge Junction, Michigan, listed on the NRHP in Lenawee County
- Franklin H. Walker House, Detroit, Michigan, listed on the NRHP
- Miller-Walker House, Saline, Michigan, listed on the NRHP in Washtenaw County
- Walker and Valentine House, Rushford, Minnesota, listed on the NRHP in Fillmore County
- Walker-Critz House, Starkville, Mississippi, listed on the NRHP in Oktibbeha County
- Walker-Woodward-Schaffer House, Palmyra, Missouri, listed on the NRHP in Marion County
- Walker House (Kalispell, Montana), listed on the NRHP in Flathead County
- Upham-Walker House, Concord, New Hampshire, listed on the NRHP in Merrimack County
- Walker-Combs-Hartshorne Farmstead, Freehold, New Jersey, listed on the NRHP in Monmouth County
- Walker House (Garrison, New York), listed on the National Register of Historic Places in Putnam County, New York
- Gifford-Walker Farm, North Bergen, New York, listed on the NRHP in Genesee County
- Walker Cottage, Saranac Lake (Harrietstown), New York, listed on the NRHP in Franklin County
- Walker's Inn, Andrews, North Carolina, listed on the NRHP in Cherokee County
- Holloway-Walker Dollarhite House, Bethel Hill, North Carolina, listed on the NRHP in Person County
- T. J. Walker Historic District, Fort Ransom, North Dakota, listed on the NRHP in Ransom County
- Christopher C. Walker House and Farm, New Madison, Ohio, listed on the NRHP in Darke County
- William Walker, Jr., House, Upper Sandusky, Ohio, listed on the NRHP in Wyandot County
- Walker House (Shawnee, Oklahoma), listed on the National Register of Historic Places in Pottawatomie County
- John P. Walker House, Ashland, Oregon, listed on the NRHP in Jackson County
- Walker-Ewing Log House, Oakdale, Pennsylvania, listed on the NRHP in Allegheny County
- Joseph Walker House, Tredyffrin Township, Pennsylvania, listed on the NRHP in eastern Chester County
- Phillip Walker House, East Providence, Rhode Island, listed on the NRHP in Providence County
- Colding-Walker House, Appleton, South Carolina, listed on the NRHP in Allendale County
- Albion Walker Chalkrock House, Tabor, South Dakota, listed on the NRHP in Bon Homme County
- James Buchanan Walker House, Centerville, Tennessee, listed on the NRHP in Hickman County
- Walker Sisters Place, a.k.a. King-Walker Place, Gatlinburg, Tennessee, listed on the NRHP in Sevier County, Tennessee
- Thomas J. Walker House, Knoxville, Tennessee
- Oliphant-Walker House, Austin, Texas, listed on the NRHP in Travis County
- James Walker Log House, Brenham, Texas, listed on the NRHP in Washington County
- J. A. Walker House and R. B. Rogers House, Brownwood, Texas, listed on the NRHP in Brown County
- Howard Walker House, Lufkin, Texas, listed on the NRHP in Angelina County
- Walker Ranch (San Antonio, Texas), San Antonio, Texas, listed on the NRHP in Bexar County
- Walker House (Shoreacres, Texas), listed on the NRHP in Harris County
- Samuel D. Walker House, Park City, Utah, listed on the NRHP in Summit County
- Maggie Lena Walker House, National Historic Site, Richmond, Virginia, listed on the NRHP
- Scott-Walker House, Saltville, Virginia, listed on the NRHP in Smyth County
- Walker House (Warren, Virginia), listed on the NRHP in Albemarle County
- Harry B. Walker House, Milwaukee, Wisconsin, listed on the NRHP in Milwaukee County
- Walker House (Mineral Point, Wisconsin), an inn and restaurant
- Kneeland-Walker House, Wauwatosa, Wisconsin, listed on the NRHP in Milwaukee County