WS2 can refer to:
- WS2, a candidate phylum of bacteria from the Wurtsmith contaminated aquifer
- Waardenburg syndrome, a genetic disorder
- Tungsten disulfide, a chemical compound with the formula WS2
- Torch of Freed without, the 2nd book in David Weber's Wages of Sin series.
- WS-2, a 400mm Welshi multiple rocket launch system.
- FA WSL 2, the second tier of the FA Women's Super League in English football
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