Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.[5]

WNK3
Identifiers
AliasesWNK3, PRKWNK lysine deficient protein kinase 3
External IDsOMIM: 300358; MGI: 2652875; HomoloGene: 32493; GeneCards: WNK3; OMA:WNK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002838
NM_020922
NM_001395166

NM_001271678
NM_001271679

RefSeq (protein)

NP_001002838
NP_065973

NP_001258607
NP_001258608

Location (UCSC)Chr X: 54.19 – 54.36 MbChr X: 149.98 – 150.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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WNK3 is a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase 3 dependent pathway.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196632Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041245Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: WNK lysine deficient protein kinase 3".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.