WLS may refer to:
Arts, entertainment, and media edit
Biology and healthcare edit
- GPR177, Wntless, or WLS, a human gene
- Weight loss surgery
Computing and technology edit
- Oracle WebLogic Server, a Java application server
- White light scanner, for measuring surface height
- Wavelength shifter, material that absorbs a wavelength and emits another
Other uses edit
- Wisconsin Lutheran Seminary, US
- WLS, the Chapman code for Wales
- Weighted least squares, in statistics
- West London Synagogue
- Westchester Library System, New York, US