View from Pizzo Uccello southward into the Val Mesolcina

The Val Mesolcina, also known as the Valle Mesolcina or Misox, is an alpine valley of the Grisons, Switzerland, stretching from the San Bernardino Pass to Grono where it joins the Calanca Valley. It is the valley of the Moesa River.

Like the Bergell or the Puschlav, the Val Mesolcina is a valley lying south of the main ridge of the Alps. Although politically the Val Mesolcina belongs to the Grisons, its population is predominantly Italian-speaking and culturally oriented towards the Ticino.

The valley includes the Mesocco and Roveredo of the Moesa district, including:

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Coordinates: 46°23′06″N 9°14′06″E / 46.385°N 9.235°E / 46.385; 9.235