VASH1

Vasohibin-1 is a protein that in humans is encoded by the VASH1 gene.

VASH1
Identifiers
Aliases	VASH1, KIAA1036, vasohibin 1, TTCP 1
External IDs	OMIM: 609011; MGI: 2442543; HomoloGene: 8941; GeneCards: VASH1; OMA:VASH1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q24.3 Start 76,761,468 bp End 76,783,015 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 D2 Start 86,725,474 bp End 86,738,865 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence C1 segment right auricle apex of heart right coronary artery right adrenal gland amygdala sural nerve left adrenal cortex right hemisphere of cerebellum Top expressed in ganglionic eminence olfactory bulb mesencephalon neural tube rhombencephalon ventricular zone cerebellum lens cerebellar cortex hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin binding metallocarboxypeptidase activity carboxypeptidase activity peptidase activity hydrolase activity Cellular component cytoplasm extracellular region apical part of cell endoplasmic reticulum extracellular space Biological process negative regulation of angiogenesis regulation of cellular senescence cell cycle negative regulation of lymphangiogenesis response to wounding regulation of angiogenesis negative regulation of blood vessel endothelial cell migration angiogenesis negative regulation of endothelial cell migration negative regulation of endothelial cell proliferation placenta blood vessel development labyrinthine layer blood vessel development proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22846 238328 Ensembl ENSG00000071246 ENSMUSG00000021256 UniProt Q7L8A9 Q8C1W1 RefSeq (mRNA) NM_014909 NM_177354 RefSeq (protein) NP_055724 NP_796328 Location (UCSC) Chr 14: 76.76 – 76.78 Mb Chr 12: 86.73 – 86.74 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
• Watanabe K, Hasegawa Y, Yamashita H, et al. (2004). "Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis". J. Clin. Invest. 114 (7): 898–907. doi:10.1172/JCI21152. PMC 518662. PMID 15467828.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shimizu K, Watanabe K, Yamashita H, et al. (2005). "Gene regulation of a novel angiogenesis inhibitor, vasohibin, in endothelial cells". Biochem. Biophys. Res. Commun. 327 (3): 700–6. doi:10.1016/j.bbrc.2004.12.073. PMID 15649403.
• Sonoda H, Ohta H, Watanabe K, et al. (2006). "Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin". Biochem. Biophys. Res. Commun. 342 (2): 640–6. doi:10.1016/j.bbrc.2006.01.185. PMID 16488400.
• Yamashita H, Abe M, Watanabe K, et al. (2006). "Vasohibin prevents arterial neointimal formation through angiogenesis inhibition". Biochem. Biophys. Res. Commun. 345 (3): 919–25. doi:10.1016/j.bbrc.2006.04.176. PMID 16707096.
• Takeda E, Suzuki Y, Yamada T, et al. (2017). "Knockout of vasohibin-1 gene in mice results in healthy longevity with reduced expression of insulin receptor, insulin receptor substrate 1, and insulin receptor substrate 2 in their white adipose tissue". Journal of Aging Research. 2017: 9851380. doi:10.1155/2017/9851380. PMC 5358453. PMID 28367331.