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Fernaldy0917
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Vaccine Storage comment:
"The general standard is the 2–8 °C cold chain for vaccine storage and transportation. This is used for all current US Food and Drug Administration (FDA)-licensed human vaccines and in low and middle-income countries."
A bit confusing. Maybe can delete "and in low and middle-income countries"
History:
The main goal was to make immunization available to every child worldwide by 1990. Immunization of six illnesses was being transported, including tuberculosis, diphtheria, pertussis, tetanus, measles, and polio.
Can be combined into one sentence.
Nowadays, engineers is still thinking of a way to eliminate refrigeration at +2 to +8C from the entire supply chain for all vaccines.
Confusing. Why eliminate refrigeration at that temperature point?
Recommended Vaccine Temperatures:
Since vaccines are sensitive biological products, proper storage and handling of vaccines are important to ensure the potency of vaccines is not lost
Maybe can be more concise, for example delete "is not lost".
Temperature to cold can result in an irreversible reaction that reduces vaccines potency and loss in adjuvant effect. Certain vaccines contain adjuvants (aluminum) that will precipitate when exposed to freezing temperatures. Temperature too hot could also result in wanted viruses permanently degrading and losing potency. However, the effects are usually smaller, gradual, and predictable than from freezing temperatures. Visible signs of physical changes after exposure to undesirable temperature are not necessary to result in a decrease of vaccine potency.
Can be more concise, many repeating contents.
Vaccine Storage and Handling Requirements:
However, the freezer compartment of this type is not recommended to store vaccines, and vaccines should be stored centrally inside the refrigerator. Many combination units cool the refrigerator using air from the freezer, resulting in different temperature zones inside the fridge. Placing vaccines near the cold air output from the freezer could cause too low temperature, and placing it at the very bottom of the refrigerator could cause too high temperature. It is important not to place vaccines near the storage unit doors because it affects the temperature and exposes vaccines to light, reducing potency for some vaccines.
Repeating sentences. Can be more concise, for example: "Placing vaccines near the cold air output from the freezer could cause too low temperature, and placing it at the very bottom of the refrigerator could cause too high temperature. It is important not to place vaccines near the storage unit doors because it affects the temperature and exposes vaccines to light, reducing potency for some vaccines."