Points left to make
- Popular press sez n-3 is anti-inflamatory, n-6 is inflamatory. But this ignores actions of SC n-6 PUFA.
- SC n6 puga can elongate to AA, but
- evidence is contradictory
- different tissues have variable elongation capabilty. In particular, the neutrophils don't elongate DGLA
- evidence is that the anti-inflamatory effects of DGLA are much larger than any effect from AA production.
- effect of linoleic acid is much smaller
- need to visit all the steps, from
- storage in cell membrane
- inflamatory event
- signal molecule induces triglyceride cleavage
- free fatty acid
- COX or 5LO
- PGEx, 5HPETE
- Series forms isomers, naming can confuse.
- Cytochrome P450 products
-- CNS
- Neurons don't elongate but other cells do.
- Fraction of the brain lipids that are AA; DHA
- Relatively little EPA
- DHA structural in the retina
- Role of eicosanoids in neural signalling
- Same messenger and receptors as in inflammation, but a different cause and a different response
- Asymmetry between n-3/6 in capture
- Additional rolses of neuroprotectin D, endocanniboids,
Disorders affected by ω-3/6 ratio
edit- NIH three strongest evidence A
- NIH many get B.
- List the C and D as well.
- List psychiatric and behavior findings.
Do something with the isoprostanes and isofurans [1] [2] [3]
Effects in the human body
edit- Contrast eicosanoid signals to other neurohormones.
- DHA 'side path'