User talk:Bcern001/sandbox
Critique on Framework Region edit
Due to the complex wording and the absence of important details, this article on the framework region may be confusing and unclear to readers. Also, there need to be at least two sources and citations added to the end of the article in case anyone is interested in expanding their knowledge on the subject. Firstly, I suggest changing “protein which belongs to the immunoglobulin superfamily” to antibody. Framework regions are only located on the variable regions of antibodies, and saying antibodies is much easier and less wordy than “protein which belongs to the immunoglobulin superfamily”[1]. Also it is important to explain that the framework region is a part of the variable region (otherwise known as the fragment antigen binding region) in order to properly explain what the function of the framework region actually is, which also should be included. For example: In molecular biology, framework regions are found on the variable region (Fab) of an antibody. The framework regions are responsible for supporting the hypervariable regions of the Fab. Another suggestion is to explain what “less “variable”” means and why the framework region is being compared to the CDR (otherwise known as the hypervariable region).[1] The side chains of certian amino acids in the Framework also help facilitate the stable binding of the antibody to the antigen[2] The second sentence needs to be removed and replaced with a more in depth explanation of the structure, where it is located on the antibody, and how many are found on each antibody. I do however like the background behind the nomenclature of the framework region in the third sentence, but it needs citations if it is going to be in the article.
Sources edit
Ill, C. R.; Gonzales, J. N.; Houtz, E. K.; Ludwig, J. R.; Melcher, E. D.; Hale, J. E.; Pourmand, R.; Keivens, V. M.; Myers, L. (1997-08-01). "Design and construction of a hybrid immunoglobulin domain with properties of both heavy and light chain variable regions". Protein Engineering. 10 (8): 949–957. ISSN 0269-2139. PMID 9415445. Abès, Riad; Dutertre, Charles-Antoine; Teillaud, Jean-Luc (2009-12-01). "[Antibodies: better knowledge for a better use]". Médecine/Sciences. 25 (12): 1011–1019. doi:10.1051/medsci/200925121011. ISSN 0767-0974. PMID 20035672.