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editLead
editDOPAL is a metabollite of dopamine by monoamine oxidase activity, or MAO, in differentiated neuronal cells of the PC12 line. Physiological concentrations of DOPAL in isolated mitochondria were highly potent in inducing a pathway associated with programmed cell death (or apoptosis), permeability transition. This suggests the cytotoxity of DOPAL and its role in the progression of Parkinson's disease, which has long been associated with mitochondrial abnormalities and neurotoxicity by way of dopaminergeic compounds, while reducing the emphasis on other dopamine derivatives and metabollites.
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editReferences
editKristal, B. S., Conway, A. D., Brown, A. M., Jain, J. C., Ulluci, P. A., Li, S. W., & Burke, W. J. (2001). Selective dopaminergic vulnerability: 3, 4-dihydroxyphenylacetaldehyde targets mitochondria. Free Radical Biology and Medicine, 30(8), 924-931.