User:Valentina Martinez Mafla/sandbox

Valentina Martinez Mafla/sandbox
Clinical data
Trade names	Claritin, Claratyne, Clarityn, others
AHFS/Drugs.com	Monograph
MedlinePlus	a697038
License data	US DailyMed: Loratadine;
Pregnancy; category	AU: B1; ;
Routes of; administration	By mouth
Drug class	Second-generation antihistamine
ATC code	R06AX13 (WHO) ;
Legal status
Legal status	CA: OTC; UK: General sales list (GSL, OTC) / Pharmacy; US: OTC / Rx-only;
Pharmacokinetic data
Bioavailability	almost 100%
Protein binding	97–99%
Metabolism	liver (CYP2D6- and 3A4-mediated)
Elimination half-life	8 hours, active metabolite desloratadine 27 hours
Excretion	40% as conjugated metabolites into urine; Similar amount into the feces
Identifiers
	IUPAC name Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate;
CAS Number	79794-75-5 ;
PubChem CID	3957;
IUPHAR/BPS	7216;
DrugBank	DB00455 ;
ChemSpider	3820 ;
UNII	7AJO3BO7QN;
KEGG	D00364 ;
ChEBI	CHEBI:6538 ;
ChEMBL	ChEMBL998 ;
Chemical and physical data
Formula	C22H23ClN2O2
Molar mass	382.89 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)N4CC/C(=C2/c1ccc(Cl)cc1CCc3cccnc23)CC4;
	InChI InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3 ; Key:JCCNYMKQOSZNPW-UHFFFAOYSA-N ;
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^ "Loratadine Use During Pregnancy". Drugs.com. 10 February 2020. Retrieved 10 April 2020.
^ "Claritin Allergy Product information". Health Canada. 25 April 2012. Retrieved 7 June 2022.
^ "Clarityn Allergy 10mg Tablets (P & GSL) - Patient Information Leaflet (PIL)". (emc). 30 August 2019. Archived from the original on 10 April 2020. Retrieved 10 April 2020.