User:Uebja/sandbox/Hydroxylamine Oxidoreductase

Hydroxylamine Oxidoreductase

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Hydroxylamine oxidoreductase (HAO) is an enzyme found in the prokaryote Nitrosomonas europaea. It plays a critically important role in the biogeochemical nitrogen cycle.

Structure

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Crystallographic methods show that HAO (PDB code: 1FGJ) is a cross-linked tetramer containing 28 heme cofactors.[1][2]

For many decades the enzyme was thought to catalyze the following reaction:

  +     +  +  

Recent work in the field, however, reveals that this enzyme catalyzes an entirely different reaction:

     +   +  

References

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  1. ^ Cedervall, Peder; Hooper, Alan B.; Wilmot, Carrie M. (2013-09-10). "Structural Studies of Hydroxylamine Oxidoreductase Reveal a Unique Heme Cofactor and a Previously Unidentified Interaction Partner". Biochemistry. 52 (36): 6211–6218. doi:10.1021/bi400960w. ISSN 0006-2960.
  2. ^ Igarashi, N.; Moriyama, H.; Fujiwara, T.; Fukumori, Y.; Tanaka, N. (April 1997). "The 2.8 A structure of hydroxylamine oxidoreductase from a nitrifying chemoautotrophic bacterium, Nitrosomonas europaea". Nature Structural Biology. 4 (4): 276–284. ISSN 1072-8368. PMID 9095195.
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