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MicroDNA are the most abundant subtype of eccDNA in humans.[1][2] They are 200-400 base pairs in length are enriched in genic sequences and CpG islands. MicroDNA have been detected the the bloodstream of cancer patients and may become a biomarker for detection of cancer.[3] Further, microDNA formation has been tied to chemotherapeutic treatment.[4]
References
editExternal links
edit- https://www.sciencedirect.com/science/article/pii/S221112471500546X
- http://science.sciencemag.org/content/336/6077/82
- http://mcr.aacrjournals.org/content/15/9/1197
- http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184365
- Review: https://www.sciencedirect.com/science/article/pii/S0168952517302305?via%3Dihub
eccDNA