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In 1953 a graduate student, Stanley Miller, and his professor, Harold Urey, performed an experiment that demonstrated how organic molecules could have spontaneously formed on early Earth from inorganic precursors. The now-famous “Miller-Urey experiment” used a highly reduced mixture of gases – methane, ammonia and hydrogen – to form basic organic monomers, such as amino acids.[1] Whether the mixture of gases used in the Miller-Urey experiment truly reflects the atmospheric content of early Earth is a controversial topic. Other less reducing gases produce a lower yield and variety. It was once thought that appreciable amounts of molecular oxygen were present in the prebiotic atmosphere, which would have essentially prevented the formation of organic molecules; however, the current scientific consensus is that such was not the case. (See Oxygen Catastrophe). The next most important step in research on prebiotic organic synthesis was the demonstration by John Oró that the nucleic acid purine base, adenine, was formed by the simple heating of solutions of ammonium cyanide.[2]
<references>
- ^ Miller, Stanley L. (1953). "A Production of Amino Acids Under Possible Primitive Earth Conditions". Science. 117: 528–529.
{{cite journal}}: Cite has empty unknown parameters:|1=and|coauthors=(help) - ^ Oró, J. (1961). "Mechanism of synthesis of adenine from hydrogen cyanide under possible primitive Earth conditions". Nature. 191: 1193–1194.
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