Sazfar21

Potential Addition to Uncompetitive Article: Effects on Biological Systems

Step 1: Adjust Mechanism Section to discuss implications of mechanism in general

Step 2: Add Section - Significance in Biochemical Systems

Step 3: Example? Figures?

5 Articles/Sources:

• Biochemistry Free for All Textbook NOTE: NEED TO FIGURE OUT HOW TO MODIFY CITATION FORMAT FOR MULTI-AUTHOR MANUALLY
  • Explains reduced Km and Vmax
  • Could help expand Mechanism section by actually explaining why they decrease and not just saying they do
• Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences.
  • Discusses restoration, which isn't really mentioned in the current page
  • Discusses some general biological implications
• Biophysical studies on agents affecting the state of membrane lipids: biochemical and pharmacological implications.
  • A few specific implications discussing membranes are brought up
  • Delipidation, perturbing submitochondrial particles, etc.
• Biology of human alkaline phosphatases with special reference to cancer.
  • Discussion of how uncompetitive inhibition can be useful in current studies; potential extra section? or maybe just add into biological/biochemical implications.
  • Potential tie in to cancer research?
• Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53.
  • Direct link of uncompetitive inhibition to cancer as a "kill switch"
  • Discusses a few basic mechanisms and how they relate to disease, ideal for biochemical significance tie in

DISCUSS WITH DR. TIENSON: IS DISCUSSING MECHANISMS OF DISEASE OKAY AS LONG AS I DON'T GO INTO PHARMACEUTICAL IMPLICATIONS AND MEDICAL ADVICE?

With regards to: Exercise: Add to an Article, I wanted to collect my sources and just practice citing them here first. I still want to discuss the possible uses of my sources before I start inserting claims all over the place on the actual article. I got practice, as my reference list worked well.

Potential Articles to Look At:

VIEW EVALUATIONS BELOW FOR MORE DETAILS. Uncompetitive Inhibitors

Presumably a future topic in the class.

Hydrophobic Collapse

Discussed fairly in depth during protein structure lectures, but the article is short.

Globular protein

Mentioned a few times and in some clicker questions that we skipped, might be fun to look into.

Proton Pump

I'm not sure if we are covering this topic but heard it mentioned when potential topics were being discussed in class. I've spent a lot of time in biology classes looking at how proton pumps are used for ATP synthesis and the like, and the article looks short enough to be expanded.

-Uncompetitive inhibitors may have the most info out there to add, but it may be difficult as well. Hydrophobic collapse might need to be cleaned up a bit, but I"m not sure how much additional information is needed. Globular protein and Proton pump are broad topics so a lot of detail is on individual example pages, but examples can be expanded on the pages themselves. Images and graphics may be the most useful thing that you could add there. - Dr. Tienson-Tseng

Article Selections/Evaluations

Uncompetitive Inhibitor-

• Is the article's content relevant to the topic?
  • The information is relevant but lots of it is just mathematical info. It does relate but the average user may not find what they want.
  • Notably lacks information in the mechanism category, and only has a few sentences before jumping into mathematical equations. Consider revising the mechanism section.
• Is it written neutrally?
  • Yes, it is written neutrally. It's pretty much only facts.
• Does each claim have a citation? Are the citations reliable?
  • Generally has a good number of citations to back up accurate claims. Most sources seem reliable (no major media, for example).

Hydro. Collapse-

• Is the article's content relevant to the topic?
  • Discusses folding and its thermodynamics in a way which is relevant and has well-supported claims.
  • Most notably lacking section to improve is likely the bit about biological importance. It's barely touched upon, and even at a glance without doing research I can think of a few things to talk about like amphipathic molecules.
• Is it written neutrally?
  • Yes, it has mostly facts and unbiased language.
• Does each claim have a citation? Are the citations reliable?
  • The page has a pretty large number of reliable sources/citations. Sources seem reliable and scientific.

Globular Proteins-

• Is the article's content relevant to the topic?
  • It has a decent amount of info but so much more could be there.
  • Extremely lacking in examples of proteins, has very little elaboration in roles of the proteins, and does not seem to discuss significance of globular vs. other types of proteins (at a glance). What it has is well written and properly backed up, but it barely has anything. Also has very few references.
• Is it written neutrally?
  • It is factual and written neutrally.
• Does each claim have a citation? Are the citations reliable?
  • The page has very few references which makes it hard to say how reliable even the present few are.

Proton pump- has lots of neutral and relevant info but with very few citations, so it is hard to say how accurate lots of it is.

• Is the article's content relevant to the topic?
  • The information that is present is relevant, but...
  • There do not seem to be any examples discussed particularly well in depth, which could be good for the article (though the function section does seem to attempt this, it feels rather underdeveloped).
• Is it written neutrally?
  • As with my other choices, it is entirely factual and pretty unbiased.
• Does each claim have a citation?
  • It's hard to say if every claim has one. However, it is likely they don't since there are like three citations for the entire page. I'm sure some of the stuff in there is uncited.
• Are the citations reliable?
  • For the aforementioned reasons, it is unlikely that they are perfectly dependable.