Lemont Kier is an American chemist and leader in the field of Medicinal Chemistry. The author of seven textbooks and over 250 research articles, Professor Lemont Kier introduced the use of molecular orbital theory to compute the preferred conformation of molecules, participated in the early development of drug design from a random search-and-formulate approach into model building activity before actually creating the molecule. He has published the first paper in which a three-dimensional model of a chemical transmitter in the central nervous system was predicted, and has also developed the current theory for defining molecules with a sweet taste.[1] In the early 1990's, he and a colleague developed a method that drug companies use to evaluate databases to find similar compounds.[2] Professor Kier has also been a leader in the development of the theory of the interaction of general anesthetic gases with the body.[3]
Professor Kier is the author or co-author of Molecular Orbital Theory In Drug Research; Molecular Connectivity In Chemistry and Drug Research (1971);[4] Molecular Connectivity in Structure Activity Analysis (1976);[5] Molecular Structure Description: The Electrotopological State (1986);[6] Medicinal Chemistry and Physics for Nurse Anesthetists (2004)[7]; Cellular Automata Modeling of Chemical Systems (2005);[8] Science and Complexity for Life Science Students (2007)[9]
(1) Sweetness, Wikipedia article
(2) Medicinal Chemistry and Physics for Nurse Anesthetists L. B. Kier and C. Dowd American Association of Nurse Anesthetists, Chicago (2004)
(3) Molecular Connectivity and SAR of General Anesthetics. T. Dipaolo, L. B. Kier and L. H. Hall, Molec. Pharmacol., 13, 31 (1977)
(4) Molecular Orbital Theory In Drug Research. L. B. Kier, Academic Press, New York (1971)
(5) Molecular Connectivity In Chemistry and Drug Research. L. B. Kier and L. H. Hall, Academic Press, New York (1976)
(6) Molecular Connectivity in Structure Activity Analysis. L. B. Kier and L. H. Hall, John Wiley Publ, London (1986)
(7) Molecular Structure Description: The Electrotopological State L. B. Kier and L. H. Hall, Academic Press, San Diego, (1999)
(8) Medicinal Chemistry and Physics for Nurse Anesthetists L. B. Kier and C. Dowd Amer. Assoc. of Nurse Anesthetists, Chicago (2004)
(9) Cellular Automata Modeling of Chemical Systems. L. B. Kier, P. G. Seybold and C.-K. Cheng, Springer, Amsterdam (2005)
Science and Complexity for Life Science Students. L. B. Kier, Kendall/Hunt, Dubuque, IO, (2007)
External Links
http://kier.rascientific.com
http://www.phc.vcu.edu/Faculty/Kier.html