- INFO: Beginning work on BXDC2... {December 20, 2007 1:31:16 PM PST}
- REDIRECT: Protein Redirected to: BXDC2 {December 20, 2007 1:32:01 PM PST}
- CREATED: Created new protein page: BXDC2 {December 20, 2007 1:32:10 PM PST}
- INFO: Beginning work on C8orf32... {December 20, 2007 1:28:59 PM PST}
- REDIRECT: Protein Redirected to: C8orf32 {December 20, 2007 1:29:34 PM PST}
- CREATED: Created new protein page: C8orf32 {December 20, 2007 1:29:42 PM PST}
- INFO: Beginning work on MCM10... {December 20, 2007 1:33:24 PM PST}
- REDIRECT: Protein Redirected to: MCM10 {December 20, 2007 1:34:06 PM PST}
- CREATED: Created new protein page: MCM10 {December 20, 2007 1:34:16 PM PST}
- INFO: Beginning work on NLE1... {December 20, 2007 1:27:54 PM PST}
- REDIRECT: Protein Redirected to: NLE1 {December 20, 2007 1:28:48 PM PST}
- CREATED: Created new protein page: NLE1 {December 20, 2007 1:28:59 PM PST}
- INFO: Beginning work on NOLA1... {December 20, 2007 1:27:09 PM PST}
- REDIRECT: Protein Redirected to: NOLA1 {December 20, 2007 1:27:45 PM PST}
- CREATED: Created new protein page: NOLA1 {December 20, 2007 1:27:54 PM PST}
- INFO: Beginning work on PHF10... {December 20, 2007 1:30:25 PM PST}
- REDIRECT: Protein Redirected to: PHF10 {December 20, 2007 1:31:06 PM PST}
- CREATED: Created new protein page: PHF10 {December 20, 2007 1:31:16 PM PST}
- INFO: Beginning work on POU5F1... {December 20, 2007 1:24:15 PM PST}
- REDIRECT: Page directory gave bad page (Oct-4). Continuing with search.. Please correct entry: <5460,Oct-4>. {December 20, 2007 1:24:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 1:25:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = POU domain, class 5, transcription factor 1
| HGNCid = 9221
| Symbol = POU5F1
| AltSymbols =; MGC22487; OCT3; OCT4; OTF3; OTF4
| OMIM = 164177
| ECnumber =
| Homologene = 8422
| MGIid = 101893
| GeneAtlas_image1 = PBB_GE_POU5F1_210265_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_POU5F1_208286_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_POU5F1_210905_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5460
| Hs_Ensembl = ENSG00000204531
| Hs_RefseqProtein = NP_002692
| Hs_RefseqmRNA = NM_002701
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 31240099
| Hs_GenLoc_end = 31246422
| Hs_Uniprot = Q01860
| Mm_EntrezGene = 18999
| Mm_Ensembl = ENSMUSG00000024406
| Mm_RefseqmRNA = NM_013633
| Mm_RefseqProtein = NP_038661
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 35114104
| Mm_GenLoc_end = 35118822
| Mm_Uniprot =
}}
}}
'''POU domain, class 5, transcription factor 1''', also known as '''POU5F1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POU5F1 POU domain, class 5, transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5460| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Takeda J, Seino S, Bell GI |title=Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. |journal=Nucleic Acids Res. |volume=20 |issue= 17 |pages= 4613-20 |year= 1992 |pmid= 1408763 |doi= }}
*{{cite journal | author=Schoorlemmer J, Kruijer W |title=Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells. |journal=Mech. Dev. |volume=36 |issue= 1-2 |pages= 75-86 |year= 1992 |pmid= 1723621 |doi= }}
*{{cite journal | author=Wey E, Lyons GE, Schäfer BW |title=A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. |journal=Eur. J. Biochem. |volume=220 |issue= 3 |pages= 753-62 |year= 1994 |pmid= 7908264 |doi= }}
*{{cite journal | author=Crouau-Roy B, Amadou C, Bouissou C, ''et al.'' |title=Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping. |journal=Genomics |volume=21 |issue= 1 |pages= 241-3 |year= 1994 |pmid= 8088794 |doi= 10.1006/geno.1994.1249 }}
*{{cite journal | author=Guillaudeux T, Mattei MG, Depetris D, ''et al.'' |title=In situ hybridization localizes the human OTF3 to chromosome 6p21.3-->p22 and OTF3L to 12p13. |journal=Cytogenet. Cell Genet. |volume=63 |issue= 4 |pages= 212-4 |year= 1993 |pmid= 8500351 |doi= }}
*{{cite journal | author=Abdel-Rahman B, Fiddler M, Rappolee D, Pergament E |title=Expression of transcription regulating genes in human preimplantation embryos. |journal=Hum. Reprod. |volume=10 |issue= 10 |pages= 2787-92 |year= 1996 |pmid= 8567814 |doi= }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi= }}
*{{cite journal | author=Inamoto S, Segil N, Pan ZQ, ''et al.'' |title=The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29852-8 |year= 1997 |pmid= 9368058 |doi= }}
*{{cite journal | author=Nichols J, Zevnik B, Anastassiadis K, ''et al.'' |title=Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. |journal=Cell |volume=95 |issue= 3 |pages= 379-91 |year= 1998 |pmid= 9814708 |doi= }}
*{{cite journal | author=Gonzalez MI, Robins DM |title=Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6420-8 |year= 2001 |pmid= 11096094 |doi= 10.1074/jbc.M008689200 }}
*{{cite journal | author=Butteroni C, De Felici M, Schöler HR, Pesce M |title=Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins. |journal=J. Mol. Biol. |volume=304 |issue= 4 |pages= 529-40 |year= 2001 |pmid= 11099378 |doi= 10.1006/jmbi.2000.4238 }}
*{{cite journal | author=Ezashi T, Ghosh D, Roberts RM |title=Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 7883-91 |year= 2001 |pmid= 11689681 |doi= 10.1128/MCB.21.23.7883-7891.2001 }}
*{{cite journal | author=Guo Y, Costa R, Ramsey H, ''et al.'' |title=The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3663-7 |year= 2002 |pmid= 11891324 |doi= 10.1073/pnas.062041099 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Looijenga LH, Stoop H, de Leeuw HP, ''et al.'' |title=POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. |journal=Cancer Res. |volume=63 |issue= 9 |pages= 2244-50 |year= 2003 |pmid= 12727846 |doi= }}
*{{cite journal | author=Wang P, Branch DR, Bali M, ''et al.'' |title=The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells. |journal=Biochem. J. |volume=375 |issue= Pt 1 |pages= 199-205 |year= 2003 |pmid= 12841847 |doi= 10.1042/BJ20030579 }}
*{{cite journal | author=Reményi A, Lins K, Nissen LJ, ''et al.'' |title=Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. |journal=Genes Dev. |volume=17 |issue= 16 |pages= 2048-59 |year= 2003 |pmid= 12923055 |doi= 10.1101/gad.269303 }}
*{{cite journal | author=Rajpert-De Meyts E, Hanstein R, Jørgensen N, ''et al.'' |title=Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads. |journal=Hum. Reprod. |volume=19 |issue= 6 |pages= 1338-44 |year= 2004 |pmid= 15105401 |doi= 10.1093/humrep/deh265 }}
*{{cite journal | author=Matin MM, Walsh JR, Gokhale PJ, ''et al.'' |title=Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells. |journal=Stem Cells |volume=22 |issue= 5 |pages= 659-68 |year= 2005 |pmid= 15342930 |doi= 10.1634/stemcells.22-5-659 }}
*{{cite journal | author=Baal N, Reisinger K, Jahr H, ''et al.'' |title=Expression of transcription factor Oct-4 and other embryonic genes in CD133 positive cells from human umbilical cord blood. |journal=Thromb. Haemost. |volume=92 |issue= 4 |pages= 767-75 |year= 2005 |pmid= 15467907 |doi= 10.1267/THRO04040767 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPID... {December 20, 2007 1:25:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPID image.jpg {December 20, 2007 1:25:59 PM PST}
- REDIRECT: Protein Redirected to: PPID {December 20, 2007 1:26:07 PM PST}
- CREATED: Created new protein page: PPID {December 20, 2007 1:26:16 PM PST}
- INFO: Beginning work on PPM1B... {December 20, 2007 1:26:16 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPM1B image.jpg {December 20, 2007 1:26:54 PM PST}
- REDIRECT: Protein Redirected to: PPM1B {December 20, 2007 1:27:01 PM PST}
- CREATED: Created new protein page: PPM1B {December 20, 2007 1:27:09 PM PST}
- INFO: Beginning work on RNMTL1... {December 20, 2007 1:29:42 PM PST}
- REDIRECT: Protein Redirected to: RNMTL1 {December 20, 2007 1:30:16 PM PST}
- CREATED: Created new protein page: RNMTL1 {December 20, 2007 1:30:25 PM PST}
- INFO: Beginning work on STRBP... {December 20, 2007 1:32:40 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein STRBP image.jpg {December 20, 2007 1:33:06 PM PST}
- REDIRECT: Protein Redirected to: STRBP {December 20, 2007 1:33:14 PM PST}
- CREATED: Created new protein page: STRBP {December 20, 2007 1:33:24 PM PST}
- INFO: Beginning work on WDR33... {December 20, 2007 1:32:10 PM PST}
- REDIRECT: Protein Redirected to: WDR33 {December 20, 2007 1:32:31 PM PST}
- CREATED: Created new protein page: WDR33 {December 20, 2007 1:32:40 PM PST}
end log.
