- INFO: Beginning work on ATXN2... {November 10, 2007 12:02:16 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:02:53 AM PST}
- CREATED: Created new protein page: ATXN2 {November 10, 2007 12:03:00 AM PST}
- INFO: Beginning work on BGLAP... {November 9, 2007 9:57:15 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein BGLAP image.jpg {November 9, 2007 9:57:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 9:57:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BGLAP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q3m.
| PDB = {{PDB2|1q3m}}, {{PDB2|1q8h}}
| Name = Bone gamma-carboxyglutamate (gla) protein (osteocalcin)
| HGNCid = 1043
| Symbol = BGLAP
| AltSymbols =; BGP; PMF1
| OMIM = 112260
| ECnumber =
| Homologene = 86974
| MGIid =
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008147 |text = structural constituent of bone}} {{GNF_GO|id=GO:0046848 |text = hydroxyapatite binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030500 |text = regulation of bone mineralization}} {{GNF_GO|id=GO:0042476 |text = odontogenesis}} {{GNF_GO|id=GO:0045124 |text = regulation of bone resorption}} {{GNF_GO|id=GO:0045670 |text = regulation of osteoclast differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 632
| Hs_Ensembl =
| Hs_RefseqProtein = NP_954642
| Hs_RefseqmRNA = NM_199173
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Bone gamma-carboxyglutamate (gla) protein (osteocalcin)''', also known as '''BGLAP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Desbois C, Karsenty G |title=Osteocalcin cluster: implications for functional studies. |journal=J. Cell. Biochem. |volume=57 |issue= 3 |pages= 379-83 |year= 1995 |pmid= 7768973 |doi= 10.1002/jcb.240570302 }}
*{{cite journal | author=Fujisawa R |title=[Recent advances in research on bone matrix proteins] |journal=Nippon Rinsho |volume=60 Suppl 3 |issue= |pages= 72-8 |year= 2002 |pmid= 11979972 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BIK... {November 9, 2007 9:57:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 9:58:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BCL2-interacting killer (apoptosis-inducing)
| HGNCid = 1051
| Symbol = BIK
| AltSymbols =; BIP1; BP4; NBK
| OMIM = 603392
| ECnumber =
| Homologene = 924
| MGIid = 1206591
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005740 |text = mitochondrial envelope}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 638
| Hs_Ensembl = ENSG00000100290
| Hs_RefseqProtein = NP_001188
| Hs_RefseqmRNA = NM_001197
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 41836701
| Hs_GenLoc_end = 41855661
| Hs_Uniprot = Q13323
| Mm_EntrezGene = 12124
| Mm_Ensembl = ENSMUSG00000016758
| Mm_RefseqmRNA = XM_001001652
| Mm_RefseqProtein = XP_001001652
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 83354629
| Mm_GenLoc_end = 83372401
| Mm_Uniprot =
}}
}}
'''BCL2-interacting killer (apoptosis-inducing)''', also known as '''BIK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.<ref>{{cite web | title = Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=638| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NFYB... {November 9, 2007 9:58:05 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NFYB image.jpg {November 9, 2007 9:59:27 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 9:59:46 PM PST}
- CREATED: Created new protein page: NFYB {November 9, 2007 9:59:53 PM PST}
- INFO: Beginning work on NSF... {November 9, 2007 9:59:54 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NSF image.jpg {November 9, 2007 10:00:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:00:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NSF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d2n.
| PDB = {{PDB2|1d2n}}, {{PDB2|1nsf}}, {{PDB2|1qcs}}, {{PDB2|1qdn}}
| Name = N-ethylmaleimide-sensitive factor
| HGNCid = 8016
| Symbol = NSF
| AltSymbols =; SKD2
| OMIM = 601633
| ECnumber =
| Homologene = 4502
| MGIid = 104560
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}} {{GNF_GO|id=GO:0019905 |text = syntaxin binding}} {{GNF_GO|id=GO:0042623 |text = ATPase activity, coupled}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4905
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001128468
| Hs_RefseqmRNA = XM_001128468
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 18195
| Mm_Ensembl = ENSMUSG00000034187
| Mm_RefseqmRNA = NM_008740
| Mm_RefseqProtein = NP_032766
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 103637872
| Mm_GenLoc_end = 103770146
| Mm_Uniprot = Q8BQ65
}}
}}
'''N-ethylmaleimide-sensitive factor''', also known as '''NSF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OXT... {November 9, 2007 10:00:19 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:00:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Oxytocin, prepro- (neurophysin I)
| HGNCid = 8528
| Symbol = OXT
| AltSymbols =; MGC126890; MGC126892; OT; OT-NPI
| OMIM = 167050
| ECnumber =
| Homologene = 55494
| MGIid = 97453
| GeneAtlas_image1 = PBB_GE_OXT_207576_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0005185 |text = neurohypophyseal hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007567 |text = parturition}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5020
| Hs_Ensembl = ENSG00000101405
| Hs_RefseqProtein = NP_000906
| Hs_RefseqmRNA = NM_000915
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 3000266
| Hs_GenLoc_end = 3001162
| Hs_Uniprot = P01178
| Mm_EntrezGene = 18429
| Mm_Ensembl = ENSMUSG00000027301
| Mm_RefseqmRNA = NM_011025
| Mm_RefseqProtein = NP_035155
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 130267614
| Mm_GenLoc_end = 130268429
| Mm_Uniprot = Q545V4
}}
}}
'''Oxytocin, prepro- (neurophysin I)''', also known as '''OXT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.<ref>{{cite web | title = Entrez Gene: OXT oxytocin, prepro- (neurophysin I)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5020| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gutkowska J, Jankowski M, Mukaddam-Daher S, McCann SM |title=Oxytocin is a cardiovascular hormone. |journal=Braz. J. Med. Biol. Res. |volume=33 |issue= 6 |pages= 625-33 |year= 2000 |pmid= 10829090 |doi= }}
*{{cite journal | author=Filippi S, Vignozzi L, Vannelli GB, ''et al.'' |title=Role of oxytocin in the ejaculatory process. |journal=J. Endocrinol. Invest. |volume=26 |issue= 3 Suppl |pages= 82-6 |year= 2004 |pmid= 12834028 |doi= }}
*{{cite journal | author=Cassoni P, Sapino A, Marrocco T, ''et al.'' |title=Oxytocin and oxytocin receptors in cancer cells and proliferation. |journal=J. Neuroendocrinol. |volume=16 |issue= 4 |pages= 362-4 |year= 2004 |pmid= 15089975 |doi= 10.1111/j.0953-8194.2004.01165.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PAWR... {November 9, 2007 10:00:56 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 10:02:11 PM PST}
- CREATED: Created new protein page: PAWR {November 9, 2007 10:02:19 PM PST}
- INFO: Beginning work on PIK3CB... {November 9, 2007 10:02:19 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:03:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phosphoinositide-3-kinase, catalytic, beta polypeptide
| HGNCid = 8976
| Symbol = PIK3CB
| AltSymbols =; PI3K; DKFZp779K1237; MGC133043; PI3Kbeta; PIK3C1; p110-BETA
| OMIM = 602925
| ECnumber =
| Homologene = 21250
| MGIid = 1922019
| GeneAtlas_image1 = PBB_GE_PIK3CB_212688_at_tn.png
| GeneAtlas_image2 = PBB_GE_PIK3CB_217620_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004428 |text = inositol or phosphatidylinositol kinase activity}} {{GNF_GO|id=GO:0016303 |text = 1-phosphatidylinositol-3-kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0043560 |text = insulin receptor substrate binding}} {{GNF_GO|id=GO:0046934 |text = phosphatidylinositol-4,5-bisphosphate 3-kinase activity}}
| Component = {{GNF_GO|id=GO:0005942 |text = phosphoinositide 3-kinase complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0001952 |text = regulation of cell-matrix adhesion}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0040016 |text = embryonic cleavage}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5291
| Hs_Ensembl = ENSG00000051382
| Hs_RefseqProtein = NP_006210
| Hs_RefseqmRNA = NM_006219
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 139856921
| Hs_GenLoc_end = 139960875
| Hs_Uniprot = P42338
| Mm_EntrezGene = 74769
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_029094
| Mm_RefseqProtein = NP_083370
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Phosphoinositide-3-kinase, catalytic, beta polypeptide''', also known as '''PIK3CB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5291| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Katada T, Kurosu H, Okada T, ''et al.'' |title=Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors. |journal=Chem. Phys. Lipids |volume=98 |issue= 1-2 |pages= 79-86 |year= 1999 |pmid= 10358930 |doi= }}
*{{cite journal | author=Lee C, Liu QH, Tomkowicz B, ''et al.'' |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676-82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPIB... {November 9, 2007 10:03:29 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPIB image.jpg {November 9, 2007 10:04:20 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 10:04:51 PM PST}
- CREATED: Created new protein page: PPIB {November 9, 2007 10:04:59 PM PST}
- INFO: Beginning work on PPT1... {November 9, 2007 10:04:59 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PPT1 image.jpg {November 9, 2007 10:05:31 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:05:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PPT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1eh5.
| PDB = {{PDB2|1eh5}}, {{PDB2|1ei9}}, {{PDB2|1exw}}
| Name = Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
| HGNCid = 9325
| Symbol = PPT1
| AltSymbols =; CLN1; INCL; PPT
| OMIM = 600722
| ECnumber =
| Homologene = 7488
| MGIid = 1298204
| GeneAtlas_image1 = PBB_GE_PPT1_200975_at_tn.png
| Function = {{GNF_GO|id=GO:0008474 |text = palmitoyl-(protein) hydrolase activity}} {{GNF_GO|id=GO:0016290 |text = palmitoyl-CoA hydrolase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}
| Process = {{GNF_GO|id=GO:0002084 |text = protein depalmitoylation}} {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0006907 |text = pinocytosis}} {{GNF_GO|id=GO:0007042 |text = lysosomal lumen acidification}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}} {{GNF_GO|id=GO:0030149 |text = sphingolipid catabolic process}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0031579 |text = lipid raft organization and biogenesis}} {{GNF_GO|id=GO:0043524 |text = negative regulation of neuron apoptosis}} {{GNF_GO|id=GO:0048260 |text = positive regulation of receptor mediated endocytosis}} {{GNF_GO|id=GO:0048549 |text = positive regulation of pinocytosis}} {{GNF_GO|id=GO:0048666 |text = neuron development}} {{GNF_GO|id=GO:0050803 |text = regulation of synapse structure and activity}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} {{GNF_GO|id=GO:0051181 |text = cofactor transport}} {{GNF_GO|id=GO:0051186 |text = cofactor metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5538
| Hs_Ensembl = ENSG00000131238
| Hs_RefseqProtein = NP_000301
| Hs_RefseqmRNA = NM_000310
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 40310964
| Hs_GenLoc_end = 40335962
| Hs_Uniprot = P50897
| Mm_EntrezGene = 19063
| Mm_Ensembl = ENSMUSG00000028657
| Mm_RefseqmRNA = NM_008917
| Mm_RefseqProtein = NP_032943
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 122338549
| Mm_GenLoc_end = 122361381
| Mm_Uniprot = Q3TAR8
}}
}}
'''Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)''', also known as '''PPT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Palmitoyl-protein thioesterase (PPT) is a small glycoprotein that removes palmitate groups from cysteine residues in lipid-modified proteins. PPT is thought to be involved in the catabolism of lipid-modified proteins (Camp et al., 1994).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PPT1 palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5538| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dawson G, Cho S |title=Batten's disease: clues to neuronal protein catabolism in lysosomes. |journal=J. Neurosci. Res. |volume=60 |issue= 2 |pages= 133-40 |year= 2000 |pmid= 10740217 |doi= }}
*{{cite journal | author=Weimer JM, Kriscenski-Perry E, Elshatory Y, Pearce DA |title=The neuronal ceroid lipofuscinoses: mutations in different proteins result in similar disease. |journal=Neuromolecular Med. |volume=1 |issue= 2 |pages= 111-24 |year= 2002 |pmid= 12025857 |doi= }}
*{{cite journal | author=Hofmann SL, Atashband A, Cho SK, ''et al.'' |title=Neuronal ceroid lipofuscinoses caused by defects in soluble lysosomal enzymes (CLN1 and CLN2). |journal=Curr. Mol. Med. |volume=2 |issue= 5 |pages= 423-37 |year= 2003 |pmid= 12125808 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMB6... {November 9, 2007 10:05:48 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PSMB6 image.jpg {November 9, 2007 10:06:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:06:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PSMB6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iru.
| PDB = {{PDB2|1iru}}
| Name = Proteasome (prosome, macropain) subunit, beta type, 6
| HGNCid = 9543
| Symbol = PSMB6
| AltSymbols =; Y; DELTA; LMPY; MGC5169
| OMIM = 600307
| ECnumber =
| Homologene = 2092
| MGIid = 104880
| GeneAtlas_image1 = PBB_GE_PSMB6_208827_at_tn.png
| Function = {{GNF_GO|id=GO:0004298 |text = threonine endopeptidase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5694
| Hs_Ensembl = ENSG00000142507
| Hs_RefseqProtein = NP_002789
| Hs_RefseqmRNA = NM_002798
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 4646397
| Hs_GenLoc_end = 4648756
| Hs_Uniprot = P28072
| Mm_EntrezGene = 19175
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_008946
| Mm_RefseqProtein = NP_032972
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Proteasome (prosome, macropain) subunit, beta type, 6''', also known as '''PSMB6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 1i (proteasome beta 9 subunit).<ref>{{cite web | title = Entrez Gene: PSMB6 proteasome (prosome, macropain) subunit, beta type, 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5694| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMD9... {November 9, 2007 10:06:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:06:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
| HGNCid = 9567
| Symbol = PSMD9
| AltSymbols =; MGC8644; p27
| OMIM = 603146
| ECnumber =
| Homologene = 2106
| MGIid = 1914401
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005838 |text = proteasome regulatory particle (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5715
| Hs_Ensembl = ENSG00000110801
| Hs_RefseqProtein = NP_002804
| Hs_RefseqmRNA = NM_002813
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 120811029
| Hs_GenLoc_end = 120840153
| Hs_Uniprot = O00233
| Mm_EntrezGene = 67151
| Mm_Ensembl = ENSMUSG00000029440
| Mm_RefseqmRNA = NM_026000
| Mm_RefseqProtein = NP_080276
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 123488864
| Mm_GenLoc_end = 123510734
| Mm_Uniprot = Q3THC1
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9''', also known as '''PSMD9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.<ref>{{cite web | title = Entrez Gene: PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5715| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTS... {November 9, 2007 10:06:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:07:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 6-pyruvoyltetrahydropterin synthase
| HGNCid = 9689
| Symbol = PTS
| AltSymbols =; PTPS
| OMIM = 261640
| ECnumber =
| Homologene = 268
| MGIid = 1338783
| GeneAtlas_image1 = PBB_GE_PTS_209694_at_tn.png
| Function = {{GNF_GO|id=GO:0003874 |text = 6-pyruvoyltetrahydropterin synthase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006520 |text = amino acid metabolic process}} {{GNF_GO|id=GO:0006559 |text = L-phenylalanine catabolic process}} {{GNF_GO|id=GO:0006729 |text = tetrahydrobiopterin biosynthetic process}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5805
| Hs_Ensembl = ENSG00000150787
| Hs_RefseqProtein = NP_000308
| Hs_RefseqmRNA = NM_000317
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 111602309
| Hs_GenLoc_end = 111609903
| Hs_Uniprot = Q03393
| Mm_EntrezGene = 19286
| Mm_Ensembl = ENSMUSG00000032067
| Mm_RefseqmRNA = NM_011220
| Mm_RefseqProtein = NP_035350
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 50273848
| Mm_GenLoc_end = 50280880
| Mm_Uniprot = Q9R1Z7
}}
}}
'''6-pyruvoyltetrahydropterin synthase''', also known as '''PTS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Werner ER, Werner-Felmayer G, Fuchs D, ''et al.'' |title=Biochemistry and function of pteridine synthesis in human and murine macrophages. |journal=Pathobiology |volume=59 |issue= 4 |pages= 276-9 |year= 1991 |pmid= 1883524 |doi= }}
*{{cite journal | author=Thöny B, Blau N |title=Mutations in the GTP cyclohydrolase I and 6-pyruvoyl-tetrahydropterin synthase genes. |journal=Hum. Mutat. |volume=10 |issue= 1 |pages= 11-20 |year= 1997 |pmid= 9222755 |doi= 10.1002/(SICI)1098-1004(1997)10:1<11::AID-HUMU2>3.0.CO;2-P }}
*{{cite journal | author=Thöny B, Auerbach G, Blau N |title=Tetrahydrobiopterin biosynthesis, regeneration and functions. |journal=Biochem. J. |volume=347 Pt 1 |issue= |pages= 1-16 |year= 2000 |pmid= 10727395 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAG1... {November 9, 2007 10:07:24 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RAG1 image.jpg {November 9, 2007 10:07:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 10:08:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RAG1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rmd.
| PDB = {{PDB2|1rmd}}
| Name = Recombination activating gene 1
| HGNCid = 9831
| Symbol = RAG1
| AltSymbols =; MGC43321; RNF74
| OMIM = 179615
| ECnumber =
| Homologene = 387
| MGIid = 97848
| GeneAtlas_image1 = PBB_GE_RAG1_206591_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007516 |text = hemocyte development}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5896
| Hs_Ensembl = ENSG00000166349
| Hs_RefseqProtein = NP_000439
| Hs_RefseqmRNA = NM_000448
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 36546139
| Hs_GenLoc_end = 36557862
| Hs_Uniprot = P15918
| Mm_EntrezGene = 19373
| Mm_Ensembl = ENSMUSG00000061311
| Mm_RefseqmRNA = NM_009019
| Mm_RefseqProtein = NP_033045
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 101442512
| Mm_GenLoc_end = 101445634
| Mm_Uniprot = Q3TR87
}}
}}
'''Recombination activating gene 1''', also known as '''RAG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The linked genes RAG1 and RAG2 act together to activate immunoglobulin V-D-J recombination. RAG1 is involved in recognition of the DNA substrate.<ref>{{cite web | title = Entrez Gene: RAG1 recombination activating gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5896| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kato M, Kimura H, Seki M, ''et al.'' |title=Omenn syndrome--review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan. |journal=Allergology international : official journal of the Japanese Society of Allergology |volume=55 |issue= 2 |pages= 115-9 |year= 2006 |pmid= 17075247 |doi= 10.2332/allergolint.55.115 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAG2... {November 9, 2007 10:08:13 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RAG2 image.jpg {November 9, 2007 11:57:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 11:57:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RAG2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2a23.
| PDB = {{PDB2|2a23}}
| Name = Recombination activating gene 2
| HGNCid = 9832
| Symbol = RAG2
| AltSymbols =;
| OMIM = 179616
| ECnumber =
| Homologene = 7507
| MGIid = 97849
| GeneAtlas_image1 = PBB_GE_RAG2_215117_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0016445 |text = somatic diversification of immunoglobulins}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}} {{GNF_GO|id=GO:0030217 |text = T cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5897
| Hs_Ensembl = ENSG00000175097
| Hs_RefseqProtein = NP_000527
| Hs_RefseqmRNA = NM_000536
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 36570071
| Hs_GenLoc_end = 36576362
| Hs_Uniprot = P55895
| Mm_EntrezGene = 19374
| Mm_Ensembl = ENSMUSG00000032864
| Mm_RefseqmRNA = NM_009020
| Mm_RefseqProtein = NP_033046
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 101425587
| Mm_GenLoc_end = 101433367
| Mm_Uniprot = Q542D1
}}
}}
'''Recombination activating gene 2''', also known as '''RAG2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kato M, Kimura H, Seki M, ''et al.'' |title=Omenn syndrome--review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan. |journal=Allergology international : official journal of the Japanese Society of Allergology |volume=55 |issue= 2 |pages= 115-9 |year= 2006 |pmid= 17075247 |doi= 10.2332/allergolint.55.115 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RBBP7... {November 9, 2007 11:57:53 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 11:58:30 PM PST}
- CREATED: Created new protein page: RBBP7 {November 9, 2007 11:58:38 PM PST}
- INFO: Beginning work on RLN2... {November 9, 2007 11:58:38 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RLN2 image.jpg {November 9, 2007 11:59:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 11:59:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RLN2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 6rlx.
| PDB = {{PDB2|6rlx}}
| Name = Relaxin 2
| HGNCid = 10027
| Symbol = RLN2
| AltSymbols =; H2; RLXH2; bA12D24.1.1; bA12D24.1.2
| OMIM = 179740
| ECnumber =
| Homologene = 55524
| MGIid = 97931
| GeneAtlas_image1 = PBB_GE_RLN2_214519_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007565 |text = female pregnancy}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6019
| Hs_Ensembl = ENSG00000107014
| Hs_RefseqProtein = NP_005050
| Hs_RefseqmRNA = NM_005059
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 5289868
| Hs_GenLoc_end = 5294969
| Hs_Uniprot = P04090
| Mm_EntrezGene = 19773
| Mm_Ensembl = ENSMUSG00000039097
| Mm_RefseqmRNA = NM_011272
| Mm_RefseqProtein = NP_035402
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 29397695
| Mm_GenLoc_end = 29400593
| Mm_Uniprot = Q2M2Q1
}}
}}
'''Relaxin 2''', also known as '''RLN2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.<ref>{{cite web | title = Entrez Gene: RLN2 relaxin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6019| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schwabe C, Büllesbach EE |title=Relaxin: structures, functions, promises, and nonevolution. |journal=FASEB J. |volume=8 |issue= 14 |pages= 1152-60 |year= 1994 |pmid= 7958621 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RNASE3... {November 9, 2007 11:59:30 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RNASE3 image.jpg {November 10, 2007 12:00:00 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:00:12 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RNASE3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dyt.
| PDB = {{PDB2|1dyt}}, {{PDB2|1h1h}}, {{PDB2|1qmt}}
| Name = Ribonuclease, RNase A family, 3 (eosinophil cationic protein)
| HGNCid = 10046
| Symbol = RNASE3
| AltSymbols =; ECP; RNS3
| OMIM = 131398
| ECnumber =
| Homologene = 48149
| MGIid = 1890465
| GeneAtlas_image1 = PBB_GE_RNASE3_206851_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004522 |text = pancreatic ribonuclease activity}} {{GNF_GO|id=GO:0004540 |text = ribonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006401 |text = RNA catabolic process}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6037
| Hs_Ensembl = ENSG00000169397
| Hs_RefseqProtein = NP_002926
| Hs_RefseqmRNA = NM_002935
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 20429402
| Hs_GenLoc_end = 20430347
| Hs_Uniprot = P12724
| Mm_EntrezGene = 93726
| Mm_Ensembl = ENSMUSG00000047222
| Mm_RefseqmRNA = NM_053113
| Mm_RefseqProtein = NP_444343
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 50177212
| Mm_GenLoc_end = 50178063
| Mm_Uniprot =
}}
}}
'''Ribonuclease, RNase A family, 3 (eosinophil cationic protein)''', also known as '''RNASE3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RPS19... {November 10, 2007 12:00:13 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:00:27 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ribosomal protein S19
| HGNCid = 10402
| Symbol = RPS19
| AltSymbols =; DBA
| OMIM = 603474
| ECnumber =
| Homologene = 37416
| MGIid = 1333780
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003735 |text = structural constituent of ribosome}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0005840 |text = ribosome}} {{GNF_GO|id=GO:0005843 |text = cytosolic small ribosomal subunit (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0007516 |text = hemocyte development}} {{GNF_GO|id=GO:0009991 |text = response to extracellular stimulus}} {{GNF_GO|id=GO:0030218 |text = erythrocyte differentiation}} {{GNF_GO|id=GO:0051272 |text = positive regulation of cell motility}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6223
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001013
| Hs_RefseqmRNA = NM_001022
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 20085
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_023133
| Mm_RefseqProtein = NP_075622
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Ribosomal protein S19''', also known as '''RPS19''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.<ref>{{cite web | title = Entrez Gene: RPS19 ribosomal protein S19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6223| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wool IG, Chan YL, Glück A |title=Structure and evolution of mammalian ribosomal proteins. |journal=Biochem. Cell Biol. |volume=73 |issue= 11-12 |pages= 933-47 |year= 1996 |pmid= 8722009 |doi= }}
*{{cite journal | author=Yamamoto T |title=Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes. |journal=Pathol. Int. |volume=57 |issue= 1 |pages= 1-11 |year= 2007 |pmid= 17199736 |doi= 10.1111/j.1440-1827.2007.02049.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RS1... {November 10, 2007 12:00:27 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:01:22 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Retinoschisis (X-linked, juvenile) 1
| HGNCid = 10457
| Symbol = RS1
| AltSymbols =; RS; XLRS1
| OMIM = 312700
| ECnumber =
| Homologene = 279
| MGIid = 1336189
| GeneAtlas_image1 = PBB_GE_RS1_207363_at_tn.png
| GeneAtlas_image2 = PBB_GE_RS1_216937_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6247
| Hs_Ensembl = ENSG00000102104
| Hs_RefseqProtein = NP_000321
| Hs_RefseqmRNA = NM_000330
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 18567733
| Hs_GenLoc_end = 18600150
| Hs_Uniprot = O15537
| Mm_EntrezGene = 20147
| Mm_Ensembl = ENSMUSG00000031293
| Mm_RefseqmRNA = NM_011302
| Mm_RefseqProtein = NP_035432
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 156112118
| Mm_GenLoc_end = 156143768
| Mm_Uniprot = Q9R1M6
}}
}}
'''Retinoschisis (X-linked, juvenile) 1''', also known as '''RS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sikkink SK, Biswas S, Parry NR, ''et al.'' |title=X-linked retinoschisis: an update. |journal=J. Med. Genet. |volume=44 |issue= 4 |pages= 225-32 |year= 2007 |pmid= 17172462 |doi= 10.1136/jmg.2006.047340 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RTN4R... {November 10, 2007 12:05:41 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RTN4R image.jpg {November 10, 2007 12:05:56 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:06:10 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RTN4R_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ozn.
| PDB = {{PDB2|1ozn}}, {{PDB2|1p8t}}
| Name = Reticulon 4 receptor
| HGNCid = 18601
| Symbol = RTN4R
| AltSymbols =; NGR; NOGOR
| OMIM = 605566
| ECnumber =
| Homologene = 11299
| MGIid = 2136886
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0007409 |text = axonogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 65078
| Hs_Ensembl = ENSG00000040608
| Hs_RefseqProtein = NP_075380
| Hs_RefseqmRNA = NM_023004
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 18608940
| Hs_GenLoc_end = 18635816
| Hs_Uniprot = Q9BZR6
| Mm_EntrezGene = 65079
| Mm_Ensembl = ENSMUSG00000043811
| Mm_RefseqmRNA = NM_022982
| Mm_RefseqProtein = NP_075358
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 18064294
| Mm_GenLoc_end = 18065694
| Mm_Uniprot = Q99PI8
}}
}}
'''Reticulon 4 receptor''', also known as '''RTN4R''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.<ref>{{cite web | title = Entrez Gene: RTN4R reticulon 4 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65078| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ng CE, Tang BL |title=Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. |journal=J. Neurosci. Res. |volume=67 |issue= 5 |pages= 559-65 |year= 2002 |pmid= 11891768 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SAA2... {November 10, 2007 12:01:22 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:02:08 AM PST}
- CREATED: Created new protein page: SAA2 {November 10, 2007 12:02:16 AM PST}
- INFO: Beginning work on SDHD... {November 10, 2007 12:03:00 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SDHD image.jpg {November 10, 2007 12:03:15 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:03:35 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SDHD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zoy.
| PDB = {{PDB2|1zoy}}, {{PDB2|1zp0}}
| Name = Succinate dehydrogenase complex, subunit D, integral membrane protein
| HGNCid = 10683
| Symbol = SDHD
| AltSymbols =; CBT1; PGL; PGL1; SDH4
| OMIM = 602690
| ECnumber =
| Homologene = 37718
| MGIid = 1914175
| Function = {{GNF_GO|id=GO:0000104 |text = succinate dehydrogenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005740 |text = mitochondrial envelope}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006099 |text = tricarboxylic acid cycle}} {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6392
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002993
| Hs_RefseqmRNA = NM_003002
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 66925
| Mm_Ensembl = ENSMUSG00000000171
| Mm_RefseqmRNA = NM_025848
| Mm_RefseqProtein = NP_080124
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 50348576
| Mm_GenLoc_end = 50356047
| Mm_Uniprot = Q9D6J9
}}
}}
'''Succinate dehydrogenase complex, subunit D, integral membrane protein''', also known as '''SDHD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The subunit D protein is one of two integral membrane proteins anchoring the complex to the matrix side of the membrane. Mutations in SDHD have been linked to hereditary paraganglioma.<ref>{{cite web | title = Entrez Gene: SDHD succinate dehydrogenase complex, subunit D, integral membrane protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6392| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Eng C, Kiuru M, Fernandez MJ, Aaltonen LA |title=A role for mitochondrial enzymes in inherited neoplasia and beyond. |journal=Nat. Rev. Cancer |volume=3 |issue= 3 |pages= 193-202 |year= 2003 |pmid= 12612654 |doi= 10.1038/nrc1013 }}
*{{cite journal | author=Martin TP, Irving RM, Maher ER |title=The genetics of paragangliomas: a review. |journal=Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery |volume=32 |issue= 1 |pages= 7-11 |year= 2007 |pmid= 17298303 |doi= 10.1111/j.1365-2273.2007.01378.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC9A3... {November 10, 2007 12:03:35 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:04:15 AM PST}
- CREATED: Created new protein page: SLC9A3 {November 10, 2007 12:04:26 AM PST}
- INFO: Beginning work on SNRPD1... {November 10, 2007 12:04:26 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SNRPD1 image.jpg {November 10, 2007 12:05:20 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 12:05:34 AM PST}
- CREATED: Created new protein page: SNRPD1 {November 10, 2007 12:05:41 AM PST}
end log.
