INFO: Beginning work on CD151... {November 9, 2007 5:24:50 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:25:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD151 molecule (Raph blood group)
| HGNCid = 1630
| Symbol = CD151
| AltSymbols =; GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24
| OMIM = 602243
| ECnumber =
| Homologene = 20916
| MGIid = 1096360
| GeneAtlas_image1 = PBB_GE_CD151_204306_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 977
| Hs_Ensembl = ENSG00000177697
| Hs_RefseqProtein = NP_001034579
| Hs_RefseqmRNA = NM_001039490
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 822961
| Hs_GenLoc_end = 828830
| Hs_Uniprot = P48509
| Mm_EntrezGene = 12476
| Mm_Ensembl = ENSMUSG00000025510
| Mm_RefseqmRNA = NM_009842
| Mm_RefseqProtein = NP_033972
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 141320142
| Mm_GenLoc_end = 141322788
| Mm_Uniprot = Q921J7
}}
}}
'''CD151 molecule (Raph blood group)''', also known as '''CD151''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.<ref>{{cite web | title = Entrez Gene: CD151 CD151 molecule (Raph blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=977| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi= }}
*{{cite journal | author=Ashman LK |title=CD151. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 3 |pages= 223-6 |year= 2003 |pmid= 12456024 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:29:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CXCL11_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rjt.
| PDB = {{PDB2|1rjt}}
| Name = Chemokine (C-X-C motif) ligand 11
| HGNCid = 10638
| Symbol = CXCL11
| AltSymbols =; H174; I-TAC; IP-9; IP9; MGC102770; SCYB11; SCYB9B; b-R1
| OMIM = 604852
| ECnumber =
| Homologene = 3944
| MGIid = 1860203
| GeneAtlas_image1 = PBB_GE_CXCL11_210163_at_tn.png
| GeneAtlas_image2 = PBB_GE_CXCL11_211122_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6373
| Hs_Ensembl = ENSG00000169248
| Hs_RefseqProtein = NP_005400
| Hs_RefseqmRNA = NM_005409
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 77173975
| Hs_GenLoc_end = 77176376
| Hs_Uniprot = O14625
| Mm_EntrezGene = 56066
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_019494
| Mm_RefseqProtein = NP_062367
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Chemokine (C-X-C motif) ligand 11''', also known as '''CXCL11''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene.<ref>{{cite web | title = Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6373| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on FOXP2... {November 9, 2007 5:45:44 PM PST}
UPLOAD: Added new Image to wiki: {November 9, 2007 5:46:24 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:46:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FOXP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2a07.
| PDB = {{PDB2|2a07}}, {{PDB2|2as5}}
| Name = Forkhead box P2
| HGNCid = 13875
| Symbol = FOXP2
| AltSymbols =; CAGH44; DKFZp686H1726; SPCH1; TNRC10
| OMIM = 605317
| ECnumber =
| Homologene = 33482
| MGIid = 2148705
| GeneAtlas_image1 = PBB_GE_FOXP2_gnf1h09377_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0021757 |text = caudate nucleus development}} {{GNF_GO|id=GO:0021758 |text = putamen development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 93986
| Hs_Ensembl = ENSG00000128573
| Hs_RefseqProtein = NP_055306
| Hs_RefseqmRNA = NM_014491
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 113842288
| Hs_GenLoc_end = 114117219
| Hs_Uniprot = O15409
| Mm_EntrezGene = 114142
| Mm_Ensembl = ENSMUSG00000029563
| Mm_RefseqmRNA = NM_053242
| Mm_RefseqProtein = NP_444472
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 15135506
| Mm_GenLoc_end = 15391977
| Mm_Uniprot = Q8BQ27
}}
}}
'''Forkhead box P2''', also known as '''FOXP2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Four alternative transcripts encoding three different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: FOXP2 forkhead box P2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93986| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vargha-Khadem F, Gadian DG, Copp A, Mishkin M |title=FOXP2 and the neuroanatomy of speech and language. |journal=Nat. Rev. Neurosci. |volume=6 |issue= 2 |pages= 131-8 |year= 2005 |pmid= 15685218 |doi= 10.1038/nrn1605 }}
*{{cite journal | author=Benítez-Burraco A |title=[FOXP2: from the specific disorder to the molecular biology of language. I. Aetiological, neuroanatomical, neurophysiological and molecular aspects] |journal=Revista de neurologia |volume=40 |issue= 11 |pages= 671-82 |year= 2005 |pmid= 15948071 |doi= }}
*{{cite journal | author=Lennon PA, Cooper ML, Peiffer DA, ''et al.'' |title=Deletion of 7q31.1 supports involvement of FOXP2 in language impairment: clinical report and review. |journal=Am. J. Med. Genet. A |volume=143 |issue= 8 |pages= 791-8 |year= 2007 |pmid= 17330859 |doi= 10.1002/ajmg.a.31632 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on GAB2... {November 9, 2007 5:43:45 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:44:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = GRB2-associated binding protein 2
| HGNCid = 14458
| Symbol = GAB2
| AltSymbols =; KIAA0571
| OMIM = 606203
| ECnumber =
| Homologene = 69067
| MGIid = 1333854
| GeneAtlas_image1 = PBB_GE_GAB2_203853_s_at_tn.png
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9846
| Hs_Ensembl = ENSG00000033327
| Hs_RefseqProtein = NP_036428
| Hs_RefseqmRNA = NM_012296
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 77603990
| Hs_GenLoc_end = 77806414
| Hs_Uniprot = Q9UQC2
| Mm_EntrezGene = 14389
| Mm_Ensembl = ENSMUSG00000004508
| Mm_RefseqmRNA = NM_010248
| Mm_RefseqProtein = NP_034378
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 96956943
| Mm_GenLoc_end = 97180228
| Mm_Uniprot = Q3ZB56
}}
}}
'''GRB2-associated binding protein 2''', also known as '''GAB2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: GAB2 GRB2-associated binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9846| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hibi M, Hirano T |title=Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. |journal=Leuk. Lymphoma |volume=37 |issue= 3-4 |pages= 299-307 |year= 2000 |pmid= 10752981 |doi= }}
*{{cite journal | author=Gold MR, Ingham RJ, McLeod SJ, ''et al.'' |title=Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase. |journal=Immunol. Rev. |volume=176 |issue= |pages= 47-68 |year= 2001 |pmid= 11043767 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on TBXAS1... {November 9, 2007 5:37:20 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:38:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
| HGNCid = 11609
| Symbol = TBXAS1
| AltSymbols =; TS; CYP5; CYP5A1; THAS; TXAS; TXS
| OMIM = 274180
| ECnumber =
| Homologene = 55549
| MGIid = 98497
| GeneAtlas_image1 = PBB_GE_TBXAS1_208130_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004796 |text = thromboxane-A synthase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016712 |text = oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001516 |text = prostaglandin biosynthetic process}} {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6916
| Hs_Ensembl = ENSG00000059377
| Hs_RefseqProtein = NP_001052
| Hs_RefseqmRNA = NM_001061
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 139124668
| Hs_GenLoc_end = 139366560
| Hs_Uniprot = P24557
| Mm_EntrezGene = 21391
| Mm_Ensembl = ENSMUSG00000029925
| Mm_RefseqmRNA = NM_011539
| Mm_RefseqProtein = NP_035669
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 38848593
| Mm_GenLoc_end = 39014194
| Mm_Uniprot = Q3UTF0
}}
}}
'''Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)''', also known as '''TBXAS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. The gene expresses two transcript variants.<ref>{{cite web | title = Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6916| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Shen RF, Tai HH |title=Thromboxanes: synthase and receptors. |journal=J. Biomed. Sci. |volume=5 |issue= 3 |pages= 153-72 |year= 1998 |pmid= 9678486 |doi= }}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Wang LH, Kulmacz RJ |title=Thromboxane synthase: structure and function of protein and gene. |journal=Prostaglandins Other Lipid Mediat. |volume=68-69 |issue= |pages= 409-22 |year= 2003 |pmid= 12432933 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on TFF2... {November 9, 2007 5:38:10 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:39:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Trefoil factor 2 (spasmolytic protein 1)
| HGNCid = 11756
| Symbol = TFF2
| AltSymbols =; SML1; SP
| OMIM = 182590
| ECnumber =
| Homologene = 3956
| MGIid = 1306805
| GeneAtlas_image1 = PBB_GE_TFF2_214476_at_tn.png
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007586 |text = digestion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7032
| Hs_Ensembl = ENSG00000160181
| Hs_RefseqProtein = NP_005414
| Hs_RefseqmRNA = NM_005423
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 42639538
| Hs_GenLoc_end = 42644176
| Hs_Uniprot = Q03403
| Mm_EntrezGene = 21785
| Mm_Ensembl = ENSMUSG00000024028
| Mm_RefseqmRNA = NM_009363
| Mm_RefseqProtein = NP_033389
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 30868938
| Mm_GenLoc_end = 30871294
| Mm_Uniprot = Q80YV5
}}
}}
'''Trefoil factor 2 (spasmolytic protein 1)''', also known as '''TFF2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.<ref>{{cite web | title = Entrez Gene: TFF2 trefoil factor 2 (spasmolytic protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7032| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Advenier C, Lagente V, Boichot E |title=The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. |journal=Eur. Respir. J. |volume=10 |issue= 8 |pages= 1892-906 |year= 1997 |pmid= 9272936 |doi= }}
*{{cite journal | author=Langer G, Jagla W, Behrens-Baumann W, ''et al.'' |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313-6 |year= 2003 |pmid= 12613926 |doi= }}
}}
{{refend}}
{{protein-stub}}
{November 9, 2007 5:46:24 PM PST} 
