INFO : Beginning work on BDKRB1... {November 10, 2007 11:07:46 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:08:28 AM PST} CREATED : Created new protein page: BDKRB1 {November 10, 2007 11:08:37 AM PST} INFO : Beginning work on BMP1... {November 10, 2007 11:08:37 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:10:00 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Bone morphogenetic protein 1
| HGNCid = 1067
| Symbol = BMP1
| AltSymbols =; FLJ44432; PCOLC; PCP; TLD
| OMIM = 112264
| ECnumber =
| Homologene = 55955
| MGIid = 88176
| GeneAtlas_image1 = PBB_GE_BMP1_207595_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BMP1_205574_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_BMP1_206725_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008533 |text = astacin activity}} {{GNF_GO|id=GO:0017026 |text = procollagen C-endopeptidase activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001502 |text = cartilage condensation}} {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 649
| Hs_Ensembl = ENSG00000168487
| Hs_RefseqProtein = NP_001190
| Hs_RefseqmRNA = NM_001199
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 22078376
| Hs_GenLoc_end = 22125784
| Hs_Uniprot = P13497
| Mm_EntrezGene = 12153
| Mm_Ensembl = ENSMUSG00000022098
| Mm_RefseqmRNA = NM_009755
| Mm_RefseqProtein = NP_033885
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 69209636
| Mm_GenLoc_end = 69255268
| Mm_Uniprot = Q6P550
}}
}}
'''Bone morphogenetic protein 1''', also known as '''BMP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region<ref>{{cite web | title = Entrez Gene: BMP1 bone morphogenetic protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=649| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on DCLRE1C... {November 10, 2007 11:35:24 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:36:37 AM PST} CREATED : Created new protein page: DCLRE1C {November 10, 2007 11:36:46 AM PST} INFO : Beginning work on FOXL2... {November 10, 2007 11:10:00 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:10:43 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Forkhead box L2
| HGNCid = 1092
| Symbol = FOXL2
| AltSymbols =; BPES; BPES1; PFRK; PINTO; POF3
| OMIM = 605597
| ECnumber =
| Homologene = 74992
| MGIid = 1349428
| GeneAtlas_image1 = PBB_GE_FOXL2_220102_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043028 |text = caspase regulator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001541 |text = ovarian follicle development}} {{GNF_GO|id=GO:0002074 |text = extraocular skeletal muscle development}} {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0019101 |text = female somatic sex determination}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0042703 |text = menstruation}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0043280 |text = positive regulation of caspase activity}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 668
| Hs_Ensembl = ENSG00000183770
| Hs_RefseqProtein = XP_001131060
| Hs_RefseqmRNA = XM_001131060
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 140147124
| Hs_GenLoc_end = 140148254
| Hs_Uniprot = P58012
| Mm_EntrezGene = 26927
| Mm_Ensembl = ENSMUSG00000050397
| Mm_RefseqmRNA = XM_976602
| Mm_RefseqProtein = XP_981696
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 98765013
| Mm_GenLoc_end = 98766140
| Mm_Uniprot = Q2TVT7
}}
}}
'''Forkhead box L2''', also known as '''FOXL2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on ITSN1... {November 10, 2007 11:28:32 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein ITSN1 image.jpg {November 10, 2007 11:30:00 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:30:21 AM PST} CREATED : Created new protein page: ITSN1 {November 10, 2007 11:30:29 AM PST} INFO : Beginning work on LCP1... {November 10, 2007 11:10:43 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein LCP1 image.jpg {November 10, 2007 11:11:14 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:11:38 AM PST} CREATED : Created new protein page: LCP1 {November 10, 2007 11:11:45 AM PST} INFO : Beginning work on LMO2... {November 10, 2007 11:11:45 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:12:23 AM PST} CREATED : Created new protein page: LMO2 {November 10, 2007 11:12:30 AM PST} INFO : Beginning work on MAP3K3... {November 10, 2007 11:12:30 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein MAP3K3 image.jpg {November 10, 2007 11:13:08 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:13:20 AM PST} CREATED : Created new protein page: MAP3K3 {November 10, 2007 11:13:29 AM PST} INFO : Beginning work on MFI2... {November 10, 2007 11:13:29 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:14:13 AM PST} CREATED : Created new protein page: MFI2 {November 10, 2007 11:14:21 AM PST} INFO : Beginning work on MTR... {November 10, 2007 11:14:21 AM PST} UPLOAD : Added new Image to wiki: {November 10, 2007 11:15:00 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:15:13 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MTR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2o2k.
| PDB = {{PDB2|2o2k}}
| Name = 5-methyltetrahydrofolate-homocysteine methyltransferase
| HGNCid = 7468
| Symbol = MTR
| AltSymbols =; FLJ45386
| OMIM = 156570
| ECnumber =
| Homologene = 37280
| MGIid = 894292
| GeneAtlas_image1 = PBB_GE_MTR_203774_at_tn.png
| Function = {{GNF_GO|id=GO:0004156 |text = dihydropteroate synthase activity}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008705 |text = methionine synthase activity}} {{GNF_GO|id=GO:0008898 |text = homocysteine S-methyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0031419 |text = cobalamin binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050897 |text = cobalt ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0008652 |text = amino acid biosynthetic process}} {{GNF_GO|id=GO:0009086 |text = methionine biosynthetic process}} {{GNF_GO|id=GO:0009396 |text = folic acid and derivative biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4548
| Hs_Ensembl = ENSG00000116984
| Hs_RefseqProtein = NP_000245
| Hs_RefseqmRNA = NM_000254
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 235025233
| Hs_GenLoc_end = 235133904
| Hs_Uniprot = Q99707
| Mm_EntrezGene = 238505
| Mm_Ensembl = ENSMUSG00000021311
| Mm_RefseqmRNA = XM_138431
| Mm_RefseqProtein = XP_138431
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 12266633
| Mm_GenLoc_end = 12312446
| Mm_Uniprot =
}}
}}
'''5-methyltetrahydrofolate-homocysteine methyltransferase''', also known as '''MTR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G.<ref>{{cite web | title = Entrez Gene: MTR 5-methyltetrahydrofolate-homocysteine methyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4548| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Banerjee RV, Matthews RG |title=Cobalamin-dependent methionine synthase. |journal=FASEB J. |volume=4 |issue= 5 |pages= 1450-9 |year= 1990 |pmid= 2407589 |doi= }}
*{{cite journal | author=Ludwig ML, Matthews RG |title=Structure-based perspectives on B12-dependent enzymes. |journal=Annu. Rev. Biochem. |volume=66 |issue= |pages= 269-313 |year= 1997 |pmid= 9242908 |doi= 10.1146/annurev.biochem.66.1.269 }}
*{{cite journal | author=Matthews RG, Sheppard C, Goulding C |title=Methylenetetrahydrofolate reductase and methionine synthase: biochemistry and molecular biology. |journal=Eur. J. Pediatr. |volume=157 Suppl 2 |issue= |pages= S54-9 |year= 1998 |pmid= 9587027 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on MTRR... {November 10, 2007 11:15:13 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:16:09 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
| HGNCid = 7473
| Symbol = MTRR
| AltSymbols =; MGC129643; MSR
| OMIM = 602568
| ECnumber =
| Homologene = 11419
| MGIid = 1891037
| GeneAtlas_image1 = PBB_GE_MTRR_203200_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MTRR_203199_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0010181 |text = FMN binding}} {{GNF_GO|id=GO:0030586 |text = [methionine synthase] reductase activity}} {{GNF_GO|id=GO:0050660 |text = FAD binding}} {{GNF_GO|id=GO:0050661 |text = NADP binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0008652 |text = amino acid biosynthetic process}} {{GNF_GO|id=GO:0009086 |text = methionine biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4552
| Hs_Ensembl = ENSG00000124275
| Hs_RefseqProtein = NP_002445
| Hs_RefseqmRNA = NM_002454
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 7922217
| Hs_GenLoc_end = 7954237
| Hs_Uniprot = Q9UBK8
| Mm_EntrezGene = 210009
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_990861
| Mm_RefseqProtein = XP_995955
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''5-methyltetrahydrofolate-homocysteine methyltransferase reductase''', also known as '''MTRR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Methionine is an essential amino acid required for protein synthesis and one carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. This gene produces two transcripts.<ref>{{cite web | title = Entrez Gene: MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4552| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on MYO5A... {November 10, 2007 11:16:09 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein MYO5A image.jpg {November 10, 2007 11:16:46 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:17:09 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MYO5A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1oe9.
| PDB = {{PDB2|1oe9}}, {{PDB2|1w7i}}, {{PDB2|1w7j}}, {{PDB2|1w8j}}, {{PDB2|2ix7}}
| Name = Myosin VA (heavy chain 12, myoxin)
| HGNCid = 7602
| Symbol = MYO5A
| AltSymbols =; GS1; MYH12; MYO5; MYOXIN; MYR12; myosin V; myosin Va
| OMIM = 160777
| ECnumber =
| Homologene = 20100
| MGIid = 105976
| GeneAtlas_image1 = PBB_GE_MYO5A_204527_at_tn.png
| Function = {{GNF_GO|id=GO:0000146 |text = microfilament motor activity}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016459 |text = myosin complex}} {{GNF_GO|id=GO:0030426 |text = growth cone}} {{GNF_GO|id=GO:0043005 |text = neuron projection}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0030048 |text = actin filament-based movement}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4644
| Hs_Ensembl = ENSG00000197535
| Hs_RefseqProtein = NP_000250
| Hs_RefseqmRNA = NM_000259
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 50392602
| Hs_GenLoc_end = 50608539
| Hs_Uniprot = Q9Y4I1
| Mm_EntrezGene = 17918
| Mm_Ensembl = ENSMUSG00000034593
| Mm_RefseqmRNA = NM_010864
| Mm_RefseqProtein = NP_034994
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 74902095
| Mm_GenLoc_end = 75003902
| Mm_Uniprot = Q99104
}}
}}
'''Myosin VA (heavy chain 12, myoxin)''', also known as '''MYO5A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on MYO6... {November 10, 2007 11:17:09 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein MYO6 image.jpg {November 10, 2007 11:18:18 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:18:32 AM PST} CREATED : Created new protein page: MYO6 {November 10, 2007 11:18:40 AM PST} INFO : Beginning work on NFKBIB... {November 10, 2007 11:18:40 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:19:35 AM PST} CREATED : Created new protein page: NFKBIB {November 10, 2007 11:19:44 AM PST} INFO : Beginning work on NKX3-1... {November 10, 2007 11:19:44 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:21:04 AM PST} CREATED : Created new protein page: NKX3-1 {November 10, 2007 11:21:12 AM PST} INFO : Beginning work on PAM... {November 10, 2007 11:21:12 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein PAM image.jpg {November 10, 2007 11:22:26 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:22:39 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PAM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1opm.
| PDB = {{PDB2|1opm}}, {{PDB2|1phm}}, {{PDB2|1sdw}}, {{PDB2|1yi9}}, {{PDB2|1yip}}, {{PDB2|1yjk}}, {{PDB2|1yjl}}, {{PDB2|3phm}}
| Name = Peptidylglycine alpha-amidating monooxygenase
| HGNCid = 8596
| Symbol = PAM
| AltSymbols =; PAL; PHM
| OMIM = 170270
| ECnumber =
| Homologene = 37369
| MGIid = 97475
| GeneAtlas_image1 = PBB_GE_PAM_202336_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PAM_212958_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PAM_214620_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0004504 |text = peptidylglycine monooxygenase activity}} {{GNF_GO|id=GO:0004598 |text = peptidylamidoglycolate lyase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} {{GNF_GO|id=GO:0031418 |text = L-ascorbic acid binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000790 |text = nuclear chromatin}} {{GNF_GO|id=GO:0000793 |text = condensed chromosome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030141 |text = secretory granule}}
| Process = {{GNF_GO|id=GO:0001519 |text = peptide amidation}} {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0006518 |text = peptide metabolic process}} {{GNF_GO|id=GO:0007076 |text = mitotic chromosome condensation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5066
| Hs_Ensembl = ENSG00000145730
| Hs_RefseqProtein = NP_000910
| Hs_RefseqmRNA = NM_000919
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 102229422
| Hs_GenLoc_end = 102394708
| Hs_Uniprot = P19021
| Mm_EntrezGene = 18484
| Mm_Ensembl = ENSMUSG00000026335
| Mm_RefseqmRNA = NM_013626
| Mm_RefseqProtein = NP_038654
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 99651500
| Mm_GenLoc_end = 99925919
| Mm_Uniprot = Q8BQ31
}}
}}
'''Peptidylglycine alpha-amidating monooxygenase''', also known as '''PAM''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known.<ref>{{cite web | title = Entrez Gene: PAM peptidylglycine alpha-amidating monooxygenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5066| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pittner RA, Albrandt K, Beaumont K, ''et al.'' |title=Molecular physiology of amylin. |journal=J. Cell. Biochem. |volume=55 Suppl |issue= |pages= 19-28 |year= 1994 |pmid= 7929615 |doi= }}
*{{cite journal | author=Eipper BA, Milgram SL, Husten EJ, ''et al.'' |title=Peptidylglycine alpha-amidating monooxygenase: a multifunctional protein with catalytic, processing, and routing domains. |journal=Protein Sci. |volume=2 |issue= 4 |pages= 489-97 |year= 1993 |pmid= 8518727 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PDCD1... {November 10, 2007 11:22:39 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:23:22 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Programmed cell death 1
| HGNCid = 8760
| Symbol = PDCD1
| AltSymbols =; CD279; PD1; SLEB2; hPD-1; hPD-l
| OMIM = 600244
| ECnumber =
| Homologene = 3681
| MGIid = 104879
| GeneAtlas_image1 = PBB_GE_PDCD1_207634_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5133
| Hs_Ensembl = ENSG00000188389
| Hs_RefseqProtein = NP_005009
| Hs_RefseqmRNA = NM_005018
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 242440711
| Hs_GenLoc_end = 242449731
| Hs_Uniprot = Q15116
| Mm_EntrezGene = 18566
| Mm_Ensembl = ENSMUSG00000026285
| Mm_RefseqmRNA = NM_008798
| Mm_RefseqProtein = NP_032824
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 95868708
| Mm_GenLoc_end = 95882959
| Mm_Uniprot = Q544F3
}}
}}
'''Programmed cell death 1''', also known as '''PDCD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.<ref>{{cite web | title = Entrez Gene: PDCD1 programmed cell death 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5133| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PHEX... {November 10, 2007 11:23:22 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:24:14 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no
| update_protein_box = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets)
| HGNCid = 8918
| Symbol = PHEX
| AltSymbols =; HPDR; HPDR1; HYP; HYP1; PEX; XLH
| OMIM = 300550
| ECnumber =
| Homologene = 37310
| MGIid = 107489
| GeneAtlas_image1 = PBB_GE_PHEX_210617_at_tn.png
| Function = {{GNF_GO|id=GO:0004177 |text = aminopeptidase activity}} {{GNF_GO|id=GO:0004245 |text = neprilysin activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5251
| Hs_Ensembl = ENSG00000102174
| Hs_RefseqProtein = NP_000435
| Hs_RefseqmRNA = NM_000444
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 21960480
| Hs_GenLoc_end = 22179348
| Hs_Uniprot = P78562
| Mm_EntrezGene = 18675
| Mm_Ensembl = ENSMUSG00000057457
| Mm_RefseqmRNA = NM_011077
| Mm_RefseqProtein = NP_035207
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 152502791
| Mm_GenLoc_end = 152759383
| Mm_Uniprot = Q3TYM9
}}
}}
'''Phosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets)''', also known as '''PHEX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tenenhouse HS |title=X-linked hypophosphataemia: a homologous disorder in humans and mice. |journal=Nephrol. Dial. Transplant. |volume=14 |issue= 2 |pages= 333-41 |year= 1999 |pmid= 10069185 |doi= }}
*{{cite journal | author=Drezner MK |title=PHEX gene and hypophosphatemia. |journal=Kidney Int. |volume=57 |issue= 1 |pages= 9-18 |year= 2000 |pmid= 10620182 |doi= 10.1046/j.1523-1755.2000.00807.x }}
*{{cite journal | author=Quarles LD |title=FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=285 |issue= 1 |pages= E1-9 |year= 2003 |pmid= 12791601 |doi= 10.1152/ajpendo.00016.2003 }}
*{{cite journal | author=Baroncelli GI, Bertelloni S, Sodini F, ''et al.'' |title=Genetic advances, biochemical and clinical features and critical approach to treatment of patients with X-linked hypophosphatemic rickets. |journal=Pediatric endocrinology reviews : PER |volume=1 |issue= 4 |pages= 361-79 |year= 2006 |pmid= 16437029 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PPP2CB... {November 10, 2007 11:24:14 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein PPP2CB image.jpg {November 10, 2007 11:25:07 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:25:17 AM PST} CREATED : Created new protein page: PPP2CB {November 10, 2007 11:25:24 AM PST} INFO : Beginning work on PPP2R5A... {November 10, 2007 11:25:24 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:26:18 AM PST} CREATED : Created new protein page: PPP2R5A {November 10, 2007 11:26:28 AM PST} INFO : Beginning work on RAD23B... {November 10, 2007 11:26:28 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein RAD23B image.jpg {November 10, 2007 11:27:20 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:27:37 AM PST} CREATED : Created new protein page: RAD23B {November 10, 2007 11:27:44 AM PST} INFO : Beginning work on RNASE1... {November 10, 2007 11:27:44 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein RNASE1 image.jpg {November 10, 2007 11:28:18 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:28:32 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RNASE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dza.
| PDB = {{PDB2|1dza}}, {{PDB2|1e21}}, {{PDB2|1h8x}}, {{PDB2|1z7x}}
| Name = Ribonuclease, RNase A family, 1 (pancreatic)
| HGNCid = 10044
| Symbol = RNASE1
| AltSymbols =; MGC12408; RIB1; RNS1
| OMIM = 180440
| ECnumber =
| Homologene = 7919
| MGIid = 97919
| GeneAtlas_image1 = PBB_GE_RNASE1_201785_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004522 |text = pancreatic ribonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6035
| Hs_Ensembl = ENSG00000129538
| Hs_RefseqProtein = NP_002924
| Hs_RefseqmRNA = NM_002933
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 20339356
| Hs_GenLoc_end = 20340876
| Hs_Uniprot = P07998
| Mm_EntrezGene = 19752
| Mm_Ensembl = ENSMUSG00000035896
| Mm_RefseqmRNA = NM_011271
| Mm_RefseqProtein = NP_035401
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 50066953
| Mm_GenLoc_end = 50068718
| Mm_Uniprot = Q8C6G3
}}
}}
'''Ribonuclease, RNase A family, 1 (pancreatic)''', also known as '''RNASE1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.<ref>{{cite web | title = Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6035| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nogués MV, Vilanova M, Cuchillo CM |title=Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites. |journal=Biochim. Biophys. Acta |volume=1253 |issue= 1 |pages= 16-24 |year= 1996 |pmid= 7492594 |doi= }}
*{{cite journal | author=Schienman JE, Holt RA, Auerbach MR, Stewart CB |title=Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys. |journal=Mol. Biol. Evol. |volume=23 |issue= 8 |pages= 1465-79 |year= 2006 |pmid= 16751256 |doi= 10.1093/molbev/msl025 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on SOX2... {November 10, 2007 11:30:29 AM PST} UPLOAD : Added new Image to wiki: {November 10, 2007 11:31:51 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:32:06 AM PST} CREATED : Created new protein page: SOX2 {November 10, 2007 11:32:14 AM PST} INFO : Beginning work on SPTBN1... {November 10, 2007 11:32:14 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein SPTBN1 image.jpg {November 10, 2007 11:33:55 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 10, 2007 11:34:10 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SPTBN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aa2.
| PDB = {{PDB2|1aa2}}, {{PDB2|1bkr}}, {{PDB2|1btn}}, {{PDB2|1mph}}
| Name = Spectrin, beta, non-erythrocytic 1
| HGNCid = 11275
| Symbol = SPTBN1
| AltSymbols =; ELF; SPTB2; betaSpII
| OMIM = 182790
| ECnumber =
| Homologene = 2354
| MGIid = 98388
| GeneAtlas_image1 = PBB_GE_SPTBN1_215918_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SPTBN1_200671_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SPTBN1_200672_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0008091 |text = spectrin}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0051016 |text = barbed-end actin filament capping}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6711
| Hs_Ensembl = ENSG00000115306
| Hs_RefseqProtein = NP_003119
| Hs_RefseqmRNA = NM_003128
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 54537143
| Hs_GenLoc_end = 54749366
| Hs_Uniprot = Q01082
| Mm_EntrezGene = 20742
| Mm_Ensembl = ENSMUSG00000020315
| Mm_RefseqmRNA = NM_009260
| Mm_RefseqProtein = NP_033286
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 29999722
| Mm_GenLoc_end = 30168144
| Mm_Uniprot = Q3TEM7
}}
}}
'''Spectrin, beta, non-erythrocytic 1''', also known as '''SPTBN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: SPTBN1 spectrin, beta, non-erythrocytic 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6711| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on SRD5A1... {November 10, 2007 11:34:10 AM PST} CREATE : Found no pages, creating new page. {November 10, 2007 11:35:16 AM PST} CREATED : Created new protein page: SRD5A1 {November 10, 2007 11:35:24 AM PST} end log.
{November 10, 2007 11:15:00 AM PST} 
{November 10, 2007 11:31:51 AM PST} 
