INFO : Beginning work on AMBP... {November 7, 2007 1:39:30 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein AMBP image.jpg {November 7, 2007 1:40:02 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:40:19 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AMBP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bik.
| PDB = {{PDB2|1bik}}
| Name = Alpha-1-microglobulin/bikunin precursor
| HGNCid = 453
| Symbol = AMBP
| AltSymbols =; HCP; ITI; ITIL; UTI
| OMIM = 176870
| ECnumber =
| Homologene = 1234
| MGIid = 88002
| GeneAtlas_image1 = PBB_GE_AMBP_205477_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0019855 |text = calcium channel inhibitor activity}} {{GNF_GO|id=GO:0019862 |text = IgA binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0030304 |text = trypsin inhibitor activity}} {{GNF_GO|id=GO:0030568 |text = plasmin inhibitor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046904 |text = calcium oxalate binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0042167 |text = heme catabolic process}} {{GNF_GO|id=GO:0046329 |text = negative regulation of JNK cascade}} {{GNF_GO|id=GO:0050777 |text = negative regulation of immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 259
| Hs_Ensembl = ENSG00000106927
| Hs_RefseqProtein = NP_001624
| Hs_RefseqmRNA = NM_001633
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 115862231
| Hs_GenLoc_end = 115880536
| Hs_Uniprot = P02760
| Mm_EntrezGene = 11699
| Mm_Ensembl = ENSMUSG00000028356
| Mm_RefseqmRNA = NM_007443
| Mm_RefseqProtein = NP_031469
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 62629637
| Mm_GenLoc_end = 62640516
| Mm_Uniprot = Q925W1
}}
}}
'''Alpha-1-microglobulin/bikunin precursor''', also known as '''AMBP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Akerström B, Lögdberg L, Berggård T, ''et al.'' |title=alpha(1)-Microglobulin: a yellow-brown lipocalin. |journal=Biochim. Biophys. Acta |volume=1482 |issue= 1-2 |pages= 172-84 |year= 2000 |pmid= 11058759 |doi= }}
*{{cite journal | author=Kobayashi H, Suzuki M, Hirashima Y, Terao T |title=The protease inhibitor bikunin, a novel anti-metastatic agent. |journal=Biol. Chem. |volume=384 |issue= 5 |pages= 749-54 |year= 2004 |pmid= 12817471 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on ATP2A2... {November 7, 2007 1:41:16 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:42:46 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
| HGNCid = 812
| Symbol = ATP2A2
| AltSymbols =; DAR; ATP2B; DD; MGC45367; SERCA2
| OMIM = 108740
| ECnumber =
| Homologene = 80167
| MGIid = 88110
| GeneAtlas_image1 = PBB_GE_ATP2A2_212361_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATP2A2_209186_at_tn.png
| GeneAtlas_image3 = PBB_GE_ATP2A2_212362_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0005388 |text = calcium-transporting ATPase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016820 |text = hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances}} {{GNF_GO|id=GO:0048155 |text = S100 alpha binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016529 |text = sarcoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0015992 |text = proton transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 488
| Hs_Ensembl = ENSG00000174437
| Hs_RefseqProtein = NP_001672
| Hs_RefseqmRNA = NM_001681
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 109203815
| Hs_GenLoc_end = 109273278
| Hs_Uniprot = P16615
| Mm_EntrezGene = 11938
| Mm_Ensembl = ENSMUSG00000029467
| Mm_RefseqmRNA = NM_009722
| Mm_RefseqProtein = NP_033852
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 122703319
| Mm_GenLoc_end = 122762791
| Mm_Uniprot = O54994
}}
}}
'''ATPase, Ca++ transporting, cardiac muscle, slow twitch 2''', also known as '''ATP2A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in two transcript variants encoding different isoforms.<ref>{{cite web | title = Entrez Gene: ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=488| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=de Meis L |title=Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis. |journal=Biosci. Rep. |volume=21 |issue= 2 |pages= 113-37 |year= 2002 |pmid= 11725862 |doi= }}
*{{cite journal | author=Frank KF, Bölck B, Brixius K, ''et al.'' |title=Modulation of SERCA: implications for the failing human heart. |journal=Basic Res. Cardiol. |volume=97 Suppl 1 |issue= |pages= I72-8 |year= 2002 |pmid= 12479238 |doi= }}
*{{cite journal | author=Ren YQ, Gao M, Liang YH, ''et al.'' |title=Five mutations of ATP2A2 gene in Chinese patients with Darier's disease and a literature review of 86 cases reported in China. |journal=Arch. Dermatol. Res. |volume=298 |issue= 2 |pages= 58-63 |year= 2007 |pmid= 16552539 |doi= 10.1007/s00403-006-0658-0 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on BIRC2... {November 7, 2007 1:40:19 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein BIRC2 image.jpg {November 7, 2007 1:40:50 PM PST} CREATE : Found no pages, creating new page. {November 7, 2007 1:41:09 PM PST} CREATED : Created new protein page: BIRC2 {November 7, 2007 1:41:16 PM PST} INFO : Beginning work on BMP7... {November 7, 2007 1:42:46 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein BMP7 image.jpg {November 7, 2007 1:44:06 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:44:23 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BMP7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bmp.
| PDB = {{PDB2|1bmp}}, {{PDB2|1lx5}}, {{PDB2|1lxi}}, {{PDB2|1m4u}}
| Name = Bone morphogenetic protein 7 (osteogenic protein 1)
| HGNCid = 1074
| Symbol = BMP7
| AltSymbols =; OP-1
| OMIM = 112267
| ECnumber =
| Homologene = 20410
| MGIid = 103302
| GeneAtlas_image1 = PBB_GE_BMP7_209591_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BMP7_209590_at_tn.png
| GeneAtlas_image3 = PBB_GE_BMP7_211259_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0001707 |text = mesoderm formation}} {{GNF_GO|id=GO:0001822 |text = kidney development}} {{GNF_GO|id=GO:0007389 |text = pattern specification process}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007435 |text = salivary gland morphogenesis}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030509 |text = BMP signaling pathway}} {{GNF_GO|id=GO:0040007 |text = growth}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0045597 |text = positive regulation of cell differentiation}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0048468 |text = cell development}} {{GNF_GO|id=GO:0048754 |text = branching morphogenesis of a tube}} {{GNF_GO|id=GO:0051216 |text = cartilage development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 655
| Hs_Ensembl = ENSG00000101144
| Hs_RefseqProtein = NP_001710
| Hs_RefseqmRNA = NM_001719
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 55177211
| Hs_GenLoc_end = 55275091
| Hs_Uniprot = P18075
| Mm_EntrezGene = 12162
| Mm_Ensembl = ENSMUSG00000008999
| Mm_RefseqmRNA = NM_007557
| Mm_RefseqProtein = NP_031583
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 172512625
| Mm_GenLoc_end = 172583232
| Mm_Uniprot = P23359
}}
}}
'''Bone morphogenetic protein 7 (osteogenic protein 1)''', also known as '''BMP7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.<ref>{{cite web | title = Entrez Gene: BMP7 bone morphogenetic protein 7 (osteogenic protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=655| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reddi AH |title=Bone morphogenetic proteins and skeletal development: the kidney-bone connection. |journal=Pediatr. Nephrol. |volume=14 |issue= 7 |pages= 598-601 |year= 2000 |pmid= 10912525 |doi= }}
*{{cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776-84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530 }}
*{{cite journal | author=Brown A, Stock G, Patel AA, ''et al.'' |title=Osteogenic protein-1 : a review of its utility in spinal applications. |journal=BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy |volume=20 |issue= 4 |pages= 243-51 |year= 2007 |pmid= 16831023 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on BTRC... {November 7, 2007 2:03:02 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein BTRC image.jpg {November 7, 2007 2:03:15 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 2:03:40 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BTRC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p22.
| PDB = {{PDB2|1p22}}
| Name = Beta-transducin repeat containing
| HGNCid = 1144
| Symbol = BTRC
| AltSymbols =; BETA-TRCP; FBW1A; FBXW1A; FWD1; MGC4643; bTrCP; bTrCP1; betaTrCP
| OMIM = 603482
| ECnumber =
| Homologene = 39330
| MGIid = 1338871
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8945
| Hs_Ensembl = ENSG00000166167
| Hs_RefseqProtein = NP_003930
| Hs_RefseqmRNA = NM_003939
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 103103810
| Hs_GenLoc_end = 103307068
| Hs_Uniprot = Q9Y297
| Mm_EntrezGene = 12234
| Mm_Ensembl = ENSMUSG00000025217
| Mm_RefseqmRNA = NM_001037758
| Mm_RefseqProtein = NP_001032847
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 45417062
| Mm_GenLoc_end = 45583324
| Mm_Uniprot =
}}
}}
'''Beta-transducin repeat containing''', also known as '''BTRC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.<ref>{{cite web | title = Entrez Gene: BTRC beta-transducin repeat containing| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8945| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Maniatis T |title=A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. |journal=Genes Dev. |volume=13 |issue= 5 |pages= 505-10 |year= 1999 |pmid= 10072378 |doi= }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on DDIT3... {November 7, 2007 1:46:25 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:47:05 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = DNA-damage-inducible transcript 3
| HGNCid = 2726
| Symbol = DDIT3
| AltSymbols =; CEBPZ; CHOP; CHOP10; GADD153; MGC4154
| OMIM = 126337
| ECnumber =
| Homologene = 3012
| MGIid = 109247
| GeneAtlas_image1 = PBB_GE_DDIT3_209383_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006974 |text = response to DNA damage stimulus}} {{GNF_GO|id=GO:0006983 |text = ER overload response}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0030503 |text = regulation of cell redox homeostasis}} {{GNF_GO|id=GO:0030968 |text = unfolded protein response}} {{GNF_GO|id=GO:0042789 |text = mRNA transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1649
| Hs_Ensembl = ENSG00000175197
| Hs_RefseqProtein = NP_004074
| Hs_RefseqmRNA = NM_004083
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 56196640
| Hs_GenLoc_end = 56200567
| Hs_Uniprot = P35638
| Mm_EntrezGene = 13198
| Mm_Ensembl = ENSMUSG00000025408
| Mm_RefseqmRNA = NM_007837
| Mm_RefseqProtein = NP_031863
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 126693757
| Mm_GenLoc_end = 126699237
| Mm_Uniprot = Q3V405
}}
}}
'''DNA-damage-inducible transcript 3''', also known as '''DDIT3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ramji DP, Foka P |title=CCAAT/enhancer-binding proteins: structure, function and regulation. |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 561-75 |year= 2002 |pmid= 12006103 |doi= 10.1042/BJ20020508 }}
*{{cite journal | author=Oyadomari S, Mori M |title=Roles of CHOP/GADD153 in endoplasmic reticulum stress. |journal=Cell Death Differ. |volume=11 |issue= 4 |pages= 381-9 |year= 2004 |pmid= 14685163 |doi= 10.1038/sj.cdd.4401373 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on EIF4EBP1... {November 7, 2007 1:47:05 PM PST} CREATE : Found no pages, creating new page. {November 7, 2007 1:47:44 PM PST} CREATED : Created new protein page: EIF4EBP1 {November 7, 2007 1:47:51 PM PST} INFO : Beginning work on FCGR2B... {November 7, 2007 1:47:51 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein FCGR2B image.jpg {November 7, 2007 1:48:06 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:48:27 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FCGR2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fcg.
| PDB = {{PDB2|1fcg}}, {{PDB2|1h9v}}, {{PDB2|2fcb}}
| Name = Fc fragment of IgG, low affinity IIb, receptor (CD32)
| HGNCid = 3618
| Symbol = FCGR2B
| AltSymbols =; CD32; FCG2; FCGR2; IGFR2; CD32B
| OMIM = 604590
| ECnumber =
| Homologene = 2974
| MGIid = 95499
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019864 |text = IgG binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2213
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001129592
| Hs_RefseqmRNA = XM_001129592
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 14130
| Mm_Ensembl = ENSMUSG00000026656
| Mm_RefseqmRNA = NM_001077189
| Mm_RefseqProtein = NP_001070657
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 172797236
| Mm_GenLoc_end = 172812709
| Mm_Uniprot = P97918
}}
}}
'''Fc fragment of IgG, low affinity IIb, receptor (CD32)''', also known as '''FCGR2B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tsuchiya N, Kyogoku C |title=Role of Fc gamma receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: insights from Asia. |journal=Autoimmunity |volume=38 |issue= 5 |pages= 347-52 |year= 2005 |pmid= 16227149 |doi= 10.1080/08916930500123926 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on FGF7... {November 7, 2007 1:48:27 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein FGF7 image.jpg {November 7, 2007 1:49:06 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:49:21 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FGF7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qqk.
| PDB = {{PDB2|1qqk}}
| Name = Fibroblast growth factor 7 (keratinocyte growth factor)
| HGNCid = 3685
| Symbol = FGF7
| AltSymbols =; HBGF-7; KGF
| OMIM = 148180
| ECnumber =
| Homologene = 7316
| MGIid = 95521
| GeneAtlas_image1 = PBB_GE_FGF7_205782_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0009611 |text = response to wounding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2252
| Hs_Ensembl = ENSG00000140285
| Hs_RefseqProtein = NP_002000
| Hs_RefseqmRNA = NM_002009
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 47502751
| Hs_GenLoc_end = 47566815
| Hs_Uniprot = P21781
| Mm_EntrezGene = 14178
| Mm_Ensembl = ENSMUSG00000027208
| Mm_RefseqmRNA = NM_008008
| Mm_RefseqProtein = NP_032034
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 125726225
| Mm_GenLoc_end = 125781969
| Mm_Uniprot = Q544I6
}}
}}
'''Fibroblast growth factor 7 (keratinocyte growth factor)''', also known as '''FGF7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.<ref>{{cite web | title = Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2252| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Beer HD, Gassmann MG, Munz B, ''et al.'' |title=Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair. |journal=J. Investig. Dermatol. Symp. Proc. |volume=5 |issue= 1 |pages= 34-9 |year= 2001 |pmid= 11147673 |doi= 10.1046/j.1087-0024.2000.00009.x }}
*{{cite journal | author=Ware LB, Matthay MA |title=Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=282 |issue= 5 |pages= L924-40 |year= 2002 |pmid= 11943656 |doi= 10.1152/ajplung.00439.2001 }}
*{{cite journal | author=Finch PW, Rubin JS |title=Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. |journal=Adv. Cancer Res. |volume=91 |issue= |pages= 69-136 |year= 2004 |pmid= 15327889 |doi= 10.1016/S0065-230X(04)91003-2 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on HTATIP... {November 7, 2007 2:04:37 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein HTATIP image.jpg {November 7, 2007 2:05:48 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 2:06:12 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HTATIP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ou2.
| PDB = {{PDB2|2ou2}}
| Name = HIV-1 Tat interacting protein, 60kDa
| HGNCid = 5275
| Symbol = HTATIP
| AltSymbols =; ESA1; HTATIP1; PLIP; TIP; TIP60; cPLA2
| OMIM = 601409
| ECnumber =
| Homologene = 4657
| MGIid = 1932051
| GeneAtlas_image1 = PBB_GE_HTATIP_206689_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_HTATIP_209192_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_HTATIP_214258_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0035267 |text = NuA4 histone acetyltransferase complex}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006302 |text = double-strand break repair}} {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}} {{GNF_GO|id=GO:0016573 |text = histone acetylation}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10524
| Hs_Ensembl = ENSG00000172977
| Hs_RefseqProtein = NP_006379
| Hs_RefseqmRNA = NM_006388
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 65236315
| Hs_GenLoc_end = 65243650
| Hs_Uniprot = Q92993
| Mm_EntrezGene = 81601
| Mm_Ensembl = ENSMUSG00000024926
| Mm_RefseqmRNA = NM_178637
| Mm_RefseqProtein = NP_848752
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 5603418
| Mm_GenLoc_end = 5610029
| Mm_Uniprot = Q3UJQ1
}}
}}
'''HIV-1 Tat interacting protein, 60kDa''', also known as '''HTATIP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.<ref>{{cite web | title = Entrez Gene: HTATIP HIV-1 Tat interacting protein, 60kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10524| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex. |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147-54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
*{{cite journal | author=Sapountzi V, Logan IR, Robson CN |title=Cellular functions of TIP60. |journal=Int. J. Biochem. Cell Biol. |volume=38 |issue= 9 |pages= 1496-509 |year= 2006 |pmid= 16698308 |doi= 10.1016/j.biocel.2006.03.003 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on HTR1A... {November 7, 2007 1:49:21 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:50:02 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5-hydroxytryptamine (serotonin) receptor 1A
| HGNCid = 5286
| Symbol = HTR1A
| AltSymbols =; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1
| OMIM = 109760
| ECnumber =
| Homologene = 20148
| MGIid = 96273
| GeneAtlas_image1 = PBB_GE_HTR1A_221351_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3350
| Hs_Ensembl = ENSG00000178394
| Hs_RefseqProtein = NP_000515
| Hs_RefseqmRNA = NM_000524
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 63292034
| Hs_GenLoc_end = 63293302
| Hs_Uniprot = P08908
| Mm_EntrezGene = 15550
| Mm_Ensembl = ENSMUSG00000021721
| Mm_RefseqmRNA = NM_008308
| Mm_RefseqProtein = NP_032334
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 106564148
| Mm_GenLoc_end = 106568501
| Mm_Uniprot = Q8BGS4
}}
}}
'''5-hydroxytryptamine (serotonin) receptor 1A''', also known as '''HTR1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=el Mestikawy S, Fargin A, Raymond JR, ''et al.'' |title=The 5-HT1A receptor: an overview of recent advances. |journal=Neurochem. Res. |volume=16 |issue= 1 |pages= 1-10 |year= 1991 |pmid= 2052135 |doi= }}
*{{cite journal | author=Hensler JG |title=Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration. |journal=Life Sci. |volume=72 |issue= 15 |pages= 1665-82 |year= 2003 |pmid= 12559389 |doi= }}
*{{cite journal | author=Van Oekelen D, Luyten WH, Leysen JE |title=5-HT2A and 5-HT2C receptors and their atypical regulation properties. |journal=Life Sci. |volume=72 |issue= 22 |pages= 2429-49 |year= 2003 |pmid= 12650852 |doi= }}
*{{cite journal | author=Lesch KP, Gutknecht L |title=Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics. |journal=Int. J. Neuropsychopharmacol. |volume=7 |issue= 4 |pages= 381-5 |year= 2005 |pmid= 15683551 |doi= 10.1017/S1461145704004845 }}
*{{cite journal | author=Kalipatnapu S, Chattopadhyay A |title=Membrane protein solubilization: recent advances and challenges in solubilization of serotonin1A receptors. |journal=IUBMB Life |volume=57 |issue= 7 |pages= 505-12 |year= 2006 |pmid= 16081372 |doi= 10.1080/15216540500167237 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on MUC5AC... {November 7, 2007 1:51:11 PM PST} CREATE : Found no pages, creating new page. {November 7, 2007 1:51:25 PM PST} CREATED : Created new protein page: MUC5AC {November 7, 2007 1:51:32 PM PST} INFO : Beginning work on MYB... {November 7, 2007 1:51:32 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein MYB image.jpg {November 7, 2007 1:52:17 PM PST} CREATE : Found no pages, creating new page. {November 7, 2007 1:52:30 PM PST} CREATED : Created new protein page: MYB {November 7, 2007 1:52:39 PM PST} INFO : Beginning work on ND6... {November 7, 2007 1:50:52 PM PST} CREATE : Found no pages, creating new page. {November 7, 2007 1:51:04 PM PST} CREATED : Created new protein page: ND6 {November 7, 2007 1:51:11 PM PST} INFO : Beginning work on NR3C2... {November 7, 2007 1:50:02 PM PST} UPLOAD : Added new Image to wiki: {November 7, 2007 1:50:34 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:50:52 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR3C2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gdc.
| PDB = {{PDB2|1gdc}}, {{PDB2|1rgd}}, {{PDB2|1y9r}}, {{PDB2|1ya3}}, {{PDB2|2a3i}}, {{PDB2|2aa2}}, {{PDB2|2aa5}}, {{PDB2|2aa6}}, {{PDB2|2aa7}}, {{PDB2|2aax}}, {{PDB2|2ab2}}, {{PDB2|2abi}}, {{PDB2|2gda}}
| Name = Nuclear receptor subfamily 3, group C, member 2
| HGNCid = 7979
| Symbol = NR3C2
| AltSymbols =; MCR; MGC133092; MLR; MR
| OMIM = 600983
| ECnumber =
| Homologene = 694
| MGIid = 99459
| GeneAtlas_image1 = PBB_GE_NR3C2_205259_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006883 |text = cellular sodium ion homeostasis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007588 |text = excretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4306
| Hs_Ensembl = ENSG00000151623
| Hs_RefseqProtein = NP_000892
| Hs_RefseqmRNA = NM_000901
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 149219370
| Hs_GenLoc_end = 149582973
| Hs_Uniprot = P08235
| Mm_EntrezGene = 110784
| Mm_Ensembl = ENSMUSG00000031618
| Mm_RefseqmRNA = XM_899576
| Mm_RefseqProtein = XP_904669
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 79804344
| Mm_GenLoc_end = 80138602
| Mm_Uniprot = Q3UW58
}}
}}
'''Nuclear receptor subfamily 3, group C, member 2''', also known as '''NR3C2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hellal-Levy C, Fagart J, Souque A, Rafestin-Oblin ME |title=Mechanistic aspects of mineralocorticoid receptor activation. |journal=Kidney Int. |volume=57 |issue= 4 |pages= 1250-5 |year= 2000 |pmid= 10760050 |doi= 10.1046/j.1523-1755.2000.00958.x }}
*{{cite journal | author=Sheppard KE |title=Nuclear receptors. II. Intestinal corticosteroid receptors. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 5 |pages= G742-6 |year= 2002 |pmid= 11960770 |doi= 10.1152/ajpgi.00531.2001 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on P4HB... {November 7, 2007 1:52:39 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein P4HB image.jpg {November 7, 2007 1:53:39 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:54:05 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_P4HB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bjx.
| PDB = {{PDB2|1bjx}}, {{PDB2|1mek}}, {{PDB2|1x5c}}, {{PDB2|2bjx}}
| Name = Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
| HGNCid = 8548
| Symbol = P4HB
| AltSymbols =; DSI; ERBA2L; GIT; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB
| OMIM = 176790
| ECnumber =
| Homologene = 55495
| MGIid = 97464
| GeneAtlas_image1 = PBB_GE_P4HB_200656_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_P4HB_200654_at_tn.png
| Function = {{GNF_GO|id=GO:0003756 |text = protein disulfide isomerase activity}} {{GNF_GO|id=GO:0004656 |text = procollagen-proline 4-dioxygenase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0015035 |text = protein disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005793 |text = ER-Golgi intermediate compartment}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0018401 |text = peptidyl-proline hydroxylation to 4-hydroxy-L-proline}} {{GNF_GO|id=GO:0045454 |text = cell redox homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5034
| Hs_Ensembl = ENSG00000185624
| Hs_RefseqProtein = NP_000909
| Hs_RefseqmRNA = NM_000918
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 77394326
| Hs_GenLoc_end = 77411680
| Hs_Uniprot = P07237
| Mm_EntrezGene = 18453
| Mm_Ensembl = ENSMUSG00000025130
| Mm_RefseqmRNA = NM_011032
| Mm_RefseqProtein = NP_035162
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 120376394
| Mm_GenLoc_end = 120389026
| Mm_Uniprot = Q3TF72
}}
}}
'''Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide''', also known as '''P4HB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.<ref>{{cite web | title = Entrez Gene: P4HB procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5034| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pihlajaniemi T, Myllylä R, Kivirikko KI |title=Prolyl 4-hydroxylase and its role in collagen synthesis. |journal=J. Hepatol. |volume=13 Suppl 3 |issue= |pages= S2-7 |year= 1992 |pmid= 1667665 |doi= }}
*{{cite journal | author=Wilkinson B, Gilbert HF |title=Protein disulfide isomerase. |journal=Biochim. Biophys. Acta |volume=1699 |issue= 1-2 |pages= 35-44 |year= 2004 |pmid= 15158710 |doi= 10.1016/j.bbapap.2004.02.017 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PDE4D... {November 7, 2007 1:54:05 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein PDE4D image.jpg {November 7, 2007 1:55:24 PM PST} CREATE : Found no pages, creating new page. {November 7, 2007 1:55:41 PM PST} CREATED : Created new protein page: PDE4D {November 7, 2007 1:55:49 PM PST} INFO : Beginning work on PLA2G4A... {November 7, 2007 1:55:49 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein PLA2G4A image.jpg {November 7, 2007 1:56:25 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:56:38 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PLA2G4A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bci.
| PDB = {{PDB2|1bci}}, {{PDB2|1cjy}}, {{PDB2|1rlw}}
| Name = Phospholipase A2, group IVA (cytosolic, calcium-dependent)
| HGNCid = 9035
| Symbol = PLA2G4A
| AltSymbols =; MGC126350; PLA2G4; cPLA2-alpha
| OMIM = 600522
| ECnumber =
| Homologene = 32059
| MGIid = 1195256
| GeneAtlas_image1 = PBB_GE_PLA2G4A_210145_at_tn.png
| Function = {{GNF_GO|id=GO:0004622 |text = lysophospholipase activity}} {{GNF_GO|id=GO:0004623 |text = phospholipase A2 activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006663 |text = platelet activating factor biosynthetic process}} {{GNF_GO|id=GO:0006690 |text = icosanoid metabolic process}} {{GNF_GO|id=GO:0009395 |text = phospholipid catabolic process}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5321
| Hs_Ensembl = ENSG00000116711
| Hs_RefseqProtein = NP_077734
| Hs_RefseqmRNA = NM_024420
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 185064708
| Hs_GenLoc_end = 185224736
| Hs_Uniprot = P47712
| Mm_EntrezGene = 18783
| Mm_Ensembl = ENSMUSG00000056220
| Mm_RefseqmRNA = NM_008869
| Mm_RefseqProtein = NP_032895
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 151591836
| Mm_GenLoc_end = 151723502
| Mm_Uniprot = Q3UMQ1
}}
}}
'''Phospholipase A2, group IVA (cytosolic, calcium-dependent)''', also known as '''PLA2G4A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.<ref>{{cite web | title = Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5321| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dennis EA |title=Diversity of group types, regulation, and function of phospholipase A2. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13057-60 |year= 1994 |pmid= 8175726 |doi= }}
*{{cite journal | author=Hirabayashi T, Murayama T, Shimizu T |title=Regulatory mechanism and physiological role of cytosolic phospholipase A2. |journal=Biol. Pharm. Bull. |volume=27 |issue= 8 |pages= 1168-73 |year= 2005 |pmid= 15305015 |doi= }}
*{{cite journal | author=Law MH, Cotton RG, Berger GE |title=The role of phospholipases A2 in schizophrenia. |journal=Mol. Psychiatry |volume=11 |issue= 6 |pages= 547-56 |year= 2006 |pmid= 16585943 |doi= 10.1038/sj.mp.4001819 }}
*{{cite journal | author=Shimizu T, Ohto T, Kita Y |title=Cytosolic phospholipase A2: biochemical properties and physiological roles. |journal=IUBMB Life |volume=58 |issue= 5-6 |pages= 328-33 |year= 2006 |pmid= 16754327 |doi= 10.1080/15216540600702289 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PRLR... {November 7, 2007 1:56:38 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein PRLR image.jpg {November 7, 2007 1:58:23 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:58:34 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
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{{GNF_Protein_box
| image = PBB_Protein_PRLR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bp3.
| PDB = {{PDB2|1bp3}}
| Name = Prolactin receptor
| HGNCid = 9446
| Symbol = PRLR
| AltSymbols =; hPRLrI
| OMIM = 176761
| ECnumber =
| Homologene = 733
| MGIid = 97763
| GeneAtlas_image1 = PBB_GE_PRLR_210476_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRLR_216638_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PRLR_206346_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004925 |text = prolactin receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0042978 |text = ornithine decarboxylase activator activity}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006694 |text = steroid biosynthetic process}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007171 |text = transmembrane receptor protein tyrosine kinase activation (dimerization)}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0007595 |text = lactation}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0030856 |text = regulation of epithelial cell differentiation}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0042977 |text = tyrosine phosphorylation of JAK2 protein}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5618
| Hs_Ensembl = ENSG00000113494
| Hs_RefseqProtein = NP_000940
| Hs_RefseqmRNA = NM_000949
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 35084621
| Hs_GenLoc_end = 35266334
| Hs_Uniprot = P16471
| Mm_EntrezGene = 19116
| Mm_Ensembl = ENSMUSG00000005268
| Mm_RefseqmRNA = NM_011169
| Mm_RefseqProtein = NP_035299
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 10121963
| Mm_GenLoc_end = 10274098
| Mm_Uniprot = Q8C5N1
}}
}}
'''Prolactin receptor''', also known as '''PRLR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bole-Feysot C, Goffin V, Edery M, ''et al.'' |title=Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. |journal=Endocr. Rev. |volume=19 |issue= 3 |pages= 225-68 |year= 1998 |pmid= 9626554 |doi= }}
*{{cite journal | author=Clevenger CV, Kline JB |title=Prolactin receptor signal transduction. |journal=Lupus |volume=10 |issue= 10 |pages= 706-18 |year= 2002 |pmid= 11721697 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PTCH1... {November 7, 2007 1:58:34 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 2:00:13 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Patched homolog 1 (Drosophila)
| HGNCid = 9585
| Symbol = PTCH1
| AltSymbols =; PTC; BCNS; FLJ42602; HPE7; NBCCS; PTC1; PTCH
| OMIM = 601309
| ECnumber =
| Homologene = 223
| MGIid = 105373
| GeneAtlas_image1 = PBB_GE_PTCH1_209815_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTCH1_208522_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PTCH1_209816_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005113 |text = patched binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008158 |text = hedgehog receptor activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001841 |text = neural tube formation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007224 |text = smoothened signaling pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0009953 |text = dorsal/ventral pattern formation}} {{GNF_GO|id=GO:0016485 |text = protein processing}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0040015 |text = negative regulation of body size}} {{GNF_GO|id=GO:0043109 |text = regulation of smoothened activity}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5727
| Hs_Ensembl = ENSG00000185920
| Hs_RefseqProtein = NP_000255
| Hs_RefseqmRNA = NM_000264
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 97245083
| Hs_GenLoc_end = 97318923
| Hs_Uniprot = Q13635
| Mm_EntrezGene = 19206
| Mm_Ensembl = ENSMUSG00000021466
| Mm_RefseqmRNA = NM_008957
| Mm_RefseqProtein = NP_032983
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 63520755
| Mm_GenLoc_end = 63574742
| Mm_Uniprot = Q3LG17
}}
}}
'''Patched homolog 1 (Drosophila)''', also known as '''PTCH1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene functions as a tumor suppressor. Mutations of this gene have been associated with nevoid basal cell carcinoma syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.<ref>{{cite web | title = Entrez Gene: PTCH1 patched homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5727| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Villavicencio EH, Walterhouse DO, Iannaccone PM |title=The sonic hedgehog-patched-gli pathway in human development and disease. |journal=Am. J. Hum. Genet. |volume=67 |issue= 5 |pages= 1047-54 |year= 2000 |pmid= 11001584 |doi= }}
*{{cite journal | author=Corcoran RB, Scott MP |title=A mouse model for medulloblastoma and basal cell nevus syndrome. |journal=J. Neurooncol. |volume=53 |issue= 3 |pages= 307-18 |year= 2002 |pmid= 11718263 |doi= }}
*{{cite journal | author=Lindström E, Shimokawa T, Toftgård R, Zaphiropoulos PG |title=PTCH mutations: distribution and analyses. |journal=Hum. Mutat. |volume=27 |issue= 3 |pages= 215-9 |year= 2006 |pmid= 16419085 |doi= 10.1002/humu.20296 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on SLC9A3R1... {November 7, 2007 2:03:40 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein SLC9A3R1 image.jpg {November 7, 2007 2:04:12 PM PST} CREATE : Found no pages, creating new page. {November 7, 2007 2:04:30 PM PST} CREATED : Created new protein page: SLC9A3R1 {November 7, 2007 2:04:37 PM PST} INFO : Beginning work on TAC1... {November 7, 2007 2:00:13 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein TAC1 image.jpg {November 7, 2007 2:00:45 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 2:01:02 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TAC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2b19.
| PDB = {{PDB2|2b19}}
| Name = Tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
| HGNCid = 11517
| Symbol = TAC1
| AltSymbols =; Hs.2563; NK2; NKNA; TAC2
| OMIM = 162320
| ECnumber =
| Homologene = 2394
| MGIid = 98474
| GeneAtlas_image1 = PBB_GE_TAC1_206552_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0043025 |text = cell soma}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007217 |text = tachykinin signaling pathway}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007320 |text = insemination}} {{GNF_GO|id=GO:0009582 |text = detection of abiotic stimulus}} {{GNF_GO|id=GO:0019233 |text = sensory perception of pain}} {{GNF_GO|id=GO:0048265 |text = response to pain}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6863
| Hs_Ensembl = ENSG00000006128
| Hs_RefseqProtein = NP_003173
| Hs_RefseqmRNA = NM_003182
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 97199311
| Hs_GenLoc_end = 97207696
| Hs_Uniprot = P20366
| Mm_EntrezGene = 21333
| Mm_Ensembl = ENSMUSG00000061762
| Mm_RefseqmRNA = XM_984642
| Mm_RefseqProtein = XP_989736
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 7505071
| Mm_GenLoc_end = 7512973
| Mm_Uniprot = Q149W7
}}
}}
'''Tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)''', also known as '''TAC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Alternative splicing of exons 4 and/or 6 produces four known products of undetermined significance.<ref>{{cite web | title = Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6863| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kowall NW, Quigley BJ, Krause JE, ''et al.'' |title=Substance P and substance P receptor histochemistry in human neurodegenerative diseases. |journal=Regul. Pept. |volume=46 |issue= 1-2 |pages= 174-85 |year= 1993 |pmid= 7692486 |doi= }}
*{{cite journal | author=Advenier C, Lagente V, Boichot E |title=The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. |journal=Eur. Respir. J. |volume=10 |issue= 8 |pages= 1892-906 |year= 1997 |pmid= 9272936 |doi= }}
*{{cite journal | author=Rameshwar P, Oh HS, Yook C, ''et al.'' |title=Substance p-fibronectin-cytokine interactions in myeloproliferative disorders with bone marrow fibrosis. |journal=Acta Haematol. |volume=109 |issue= 1 |pages= 1-10 |year= 2003 |pmid= 12486316 |doi= }}
*{{cite journal | author=Saito R, Takano Y, Kamiya HO |title=Roles of substance P and NK(1) receptor in the brainstem in the development of emesis. |journal=J. Pharmacol. Sci. |volume=91 |issue= 2 |pages= 87-94 |year= 2003 |pmid= 12686752 |doi= }}
*{{cite journal | author=Di Angelantonio S, Giniatullin R, Costa V, ''et al.'' |title=Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells. |journal=Br. J. Pharmacol. |volume=139 |issue= 6 |pages= 1061-73 |year= 2004 |pmid= 12871824 |doi= 10.1038/sj.bjp.0705337 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on TWIST1... {November 7, 2007 2:01:02 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 2:02:01 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)
| HGNCid = 12428
| Symbol = TWIST1
| AltSymbols =; ACS3; BPES2; BPES3; SCS; TWIST
| OMIM = 601622
| ECnumber =
| Homologene = 402
| MGIid = 98872
| GeneAtlas_image1 = PBB_GE_TWIST1_213943_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0004857 |text = enzyme inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0001843 |text = neural tube closure}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0035137 |text = hindlimb morphogenesis}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0045843 |text = negative regulation of striated muscle development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7291
| Hs_Ensembl = ENSG00000122691
| Hs_RefseqProtein = NP_000465
| Hs_RefseqmRNA = NM_000474
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 19121633
| Hs_GenLoc_end = 19123820
| Hs_Uniprot = Q15672
| Mm_EntrezGene = 22160
| Mm_Ensembl = ENSMUSG00000035799
| Mm_RefseqmRNA = NM_011658
| Mm_RefseqProtein = NP_035788
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 34542918
| Mm_GenLoc_end = 34545078
| Mm_Uniprot = P26687
}}
}}
'''Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)''', also known as '''TWIST1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.<ref>{{cite web | title = Entrez Gene: TWIST1 twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7291| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Seto ML, Lee SJ, Sze RW, Cunningham ML |title=Another TWIST on Baller-Gerold syndrome. |journal=Am. J. Med. Genet. |volume=104 |issue= 4 |pages= 323-30 |year= 2002 |pmid= 11754069 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on VCAN... {November 7, 2007 1:44:23 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 1:46:25 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Versican
| HGNCid = 2464
| Symbol = VCAN
| AltSymbols =; CSPG2; DKFZp686K06110; ERVR; PG-M; WGN; WGN1
| OMIM = 118661
| ECnumber =
| Homologene = 3228
| MGIid = 102889
| GeneAtlas_image1 = PBB_GE_VCAN_204620_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VCAN_204619_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_VCAN_211571_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0005540 |text = hyaluronic acid binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008037 |text = cell recognition}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1462
| Hs_Ensembl = ENSG00000038427
| Hs_RefseqProtein = NP_004376
| Hs_RefseqmRNA = NM_004385
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 82803339
| Hs_GenLoc_end = 82912737
| Hs_Uniprot = P13611
| Mm_EntrezGene = 13003
| Mm_Ensembl = ENSMUSG00000021614
| Mm_RefseqmRNA = XM_488510
| Mm_RefseqProtein = XP_488510
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 90131260
| Mm_GenLoc_end = 90216522
| Mm_Uniprot = P70267
}}
}}
'''Versican''', also known as '''VCAN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wight TN, Merrilees MJ |title=Proteoglycans in atherosclerosis and restenosis: key roles for versican. |journal=Circ. Res. |volume=94 |issue= 9 |pages= 1158-67 |year= 2004 |pmid= 15142969 |doi= 10.1161/01.RES.0000126921.29919.51 }}
*{{cite journal | author=Kenagy RD, Plaas AH, Wight TN |title=Versican degradation and vascular disease. |journal=Trends Cardiovasc. Med. |volume=16 |issue= 6 |pages= 209-15 |year= 2006 |pmid= 16839865 |doi= 10.1016/j.tcm.2006.03.011 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on VDAC1... {November 7, 2007 2:02:01 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 7, 2007 2:03:02 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Voltage-dependent anion channel 1
| HGNCid = 12669
| Symbol = VDAC1
| AltSymbols =; MGC111064; PORIN; PORIN-31-HL
| OMIM = 604492
| ECnumber =
| Homologene = 36115
| MGIid = 106919
| GeneAtlas_image1 = PBB_GE_VDAC1_212038_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VDAC1_217140_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008308 |text = voltage-gated ion-selective channel activity}} {{GNF_GO|id=GO:0015283 |text = apoptogenic cytochrome c release channel activity}} {{GNF_GO|id=GO:0015482 |text = voltage-gated anion channel porin activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019867 |text = outer membrane}}
| Process = {{GNF_GO|id=GO:0006820 |text = anion transport}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7416
| Hs_Ensembl = ENSG00000073905
| Hs_RefseqProtein = NP_003365
| Hs_RefseqmRNA = NM_003374
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 133335506
| Hs_GenLoc_end = 133368723
| Hs_Uniprot = P21796
| Mm_EntrezGene = 22333
| Mm_Ensembl = ENSMUSG00000020402
| Mm_RefseqmRNA = NM_011694
| Mm_RefseqProtein = NP_035824
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 52204283
| Mm_GenLoc_end = 52232820
| Mm_Uniprot = Q3THL7
}}
}}
'''Voltage-dependent anion channel 1''', also known as '''VDAC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Verrier F, Mignotte B, Jan G, Brenner C |title=Study of PTPC composition during apoptosis for identification of viral protein target. |journal=Ann. N. Y. Acad. Sci. |volume=1010 |issue= |pages= 126-42 |year= 2004 |pmid= 15033708 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
{November 7, 2007 1:50:34 PM PST} 
