AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:21:17 PM PDT}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CCNE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1w98.
| PDB = {{PDB2|1w98}}
| Name = Cyclin E1
| HGNCid = 1589
| Symbol = CCNE1
| AltSymbols =; CCNE
| OMIM = 123837
| ECnumber =
| Homologene = 14452
| MGIid = 88316
| GeneAtlas_image1 = PBB_GE_CCNE1_213523_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016538 |text = cyclin-dependent protein kinase regulator activity}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0000307 |text = cyclin-dependent protein kinase holoenzyme complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006270 |text = DNA replication initiation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 898
| Hs_Ensembl = ENSG00000105173
| Hs_RefseqProtein = NP_001229
| Hs_RefseqmRNA = NM_001238
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 34994741
| Hs_GenLoc_end = 35007056
| Hs_Uniprot = P24864
| Mm_EntrezGene = 12447
| Mm_Ensembl = ENSMUSG00000002068
| Mm_RefseqmRNA = NM_007633
| Mm_RefseqProtein = NP_031659
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 37806746
| Mm_GenLoc_end = 37816294
| Mm_Uniprot = A0JLN2
}}
}}
'''Cyclin E1''', also known as '''CCNE1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.<ref>{{cite web | title = Entrez Gene: CCNE1 cyclin E1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=898| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Akita H |title=[Prognostic importance of altered expression of cell cycle regulators in lung cancer] |journal=Nippon Rinsho |volume=60 Suppl 5 |issue= |pages= 267-71 |year= 2003 |pmid= 12101670 |doi= }}
*{{cite journal | author=Mazumder S, DuPree EL, Almasan A |title=A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy. |journal=Current cancer drug targets |volume=4 |issue= 1 |pages= 65-75 |year= 2004 |pmid= 14965268 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on CD36... {November 3, 2007 4:21:17 PM PDT}
AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:22:01 PM PDT}
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{{PBB_Controls
| update_page = yes
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| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD36 molecule (thrombospondin receptor)
| HGNCid = 1663
| Symbol = CD36
| AltSymbols =; FAT; GP3B; GP4; GPIV; PASIV; SCARB3
| OMIM = 173510
| ECnumber =
| Homologene = 73871
| MGIid = 107899
| GeneAtlas_image1 = PBB_GE_CD36_206488_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 948
| Hs_Ensembl = ENSG00000135218
| Hs_RefseqProtein = NP_000063
| Hs_RefseqmRNA = NM_000072
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 80069459
| Hs_GenLoc_end = 80141668
| Hs_Uniprot = P16671
| Mm_EntrezGene = 12491
| Mm_Ensembl = ENSMUSG00000002944
| Mm_RefseqmRNA = NM_007643
| Mm_RefseqProtein = NP_031669
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 17297546
| Mm_GenLoc_end = 17340718
| Mm_Uniprot = Q3TA14
}}
}}
'''CD36 molecule (thrombospondin receptor)''', also known as '''CD36''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.<ref>{{cite web | title = Entrez Gene: CD36 CD36 molecule (thrombospondin receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=948| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Abumrad NA, Ajmal M, Pothakos K, Robinson JK |title=CD36 expression and brain function: does CD36 deficiency impact learning ability? |journal=Prostaglandins Other Lipid Mediat. |volume=77 |issue= 1-4 |pages= 77-83 |year= 2005 |pmid= 16099393 |doi= 10.1016/j.prostaglandins.2004.09.012 }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 10:46:47 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FADD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a1w.
| PDB = {{PDB2|1a1w}}, {{PDB2|1a1z}}, {{PDB2|1e3y}}, {{PDB2|1e41}}, {{PDB2|2gf5}}
| Name = Fas (TNFRSF6)-associated via death domain
| HGNCid = 3573
| Symbol = FADD
| AltSymbols =; GIG3; MGC8528; MORT1
| OMIM = 602457
| ECnumber =
| Homologene = 2836
| MGIid = 109324
| GeneAtlas_image1 = PBB_GE_FADD_202535_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005123 |text = death receptor binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8772
| Hs_Ensembl = ENSG00000168040
| Hs_RefseqProtein = NP_003815
| Hs_RefseqmRNA = NM_003824
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 69726917
| Hs_GenLoc_end = 69731134
| Hs_Uniprot = Q13158
| Mm_EntrezGene = 14082
| Mm_Ensembl = ENSMUSG00000031077
| Mm_RefseqmRNA = NM_010175
| Mm_RefseqProtein = NP_034305
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 144387713
| Mm_GenLoc_end = 144391826
| Mm_Uniprot = Q8CD57
}}
}}
'''Fas (TNFRSF6)-associated via death domain''', also known as '''FADD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.<ref>{{cite web | title = Entrez Gene: FADD Fas (TNFRSF6)-associated via death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8772| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sheikh MS, Huang Y |title=The FADD is going nuclear. |journal=Cell Cycle |volume=2 |issue= 4 |pages= 346-7 |year= 2004 |pmid= 12851487 |doi= }}
*{{cite journal | author=Bhojani MS, Chen G, Ross BD, ''et al.'' |title=Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer. |journal=Cell Cycle |volume=4 |issue= 11 |pages= 1478-81 |year= 2007 |pmid= 16258269 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on HSPA5... {November 3, 2007 4:49:09 PM PDT}
AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 4:49:57 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
| HGNCid = 5238
| Symbol = HSPA5
| AltSymbols =; MIF2; BIP; FLJ26106; GRP78
| OMIM = 138120
| ECnumber =
| Homologene = 3908
| MGIid = 95835
| GeneAtlas_image1 = PBB_GE_HSPA5_211936_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}} {{GNF_GO|id=GO:0043022 |text = ribosome binding}} {{GNF_GO|id=GO:0043027 |text = caspase inhibitor activity}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005788 |text = endoplasmic reticulum lumen}} {{GNF_GO|id=GO:0005793 |text = ER-Golgi intermediate compartment}} {{GNF_GO|id=GO:0008303 |text = caspase complex}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0030176 |text = integral to endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006983 |text = ER overload response}} {{GNF_GO|id=GO:0043154 |text = negative regulation of caspase activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3309
| Hs_Ensembl = ENSG00000044574
| Hs_RefseqProtein = NP_005338
| Hs_RefseqmRNA = NM_005347
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 127036953
| Hs_GenLoc_end = 127043430
| Hs_Uniprot = P11021
| Mm_EntrezGene = 14828
| Mm_Ensembl = ENSMUSG00000026864
| Mm_RefseqmRNA = NM_022310
| Mm_RefseqProtein = NP_071705
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 34594099
| Mm_GenLoc_end = 34598538
| Mm_Uniprot = Q3TI47
}}
}}
'''Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)''', also known as '''HSPA5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3309| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Li J, Lee AS |title=Stress induction of GRP78/BiP and its role in cancer. |journal=Curr. Mol. Med. |volume=6 |issue= 1 |pages= 45-54 |year= 2006 |pmid= 16472112 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 5:04:22 PM PDT}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_OGG1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ebm.
| PDB = {{PDB2|1ebm}}, {{PDB2|1fn7}}, {{PDB2|1hu0}}, {{PDB2|1ko9}}, {{PDB2|1lwv}}, {{PDB2|1lww}}, {{PDB2|1lwy}}, {{PDB2|1m3h}}, {{PDB2|1m3q}}, {{PDB2|1n39}}, {{PDB2|1n3a}}, {{PDB2|1n3c}}, {{PDB2|1yqk}}, {{PDB2|1yql}}, {{PDB2|1yqm}}, {{PDB2|1yqr}}, {{PDB2|2i5w}}, {{PDB2|2nob}}, {{PDB2|2noe}}, {{PDB2|2nof}}, {{PDB2|2noh}}, {{PDB2|2noi}}, {{PDB2|2nol}}, {{PDB2|2noz}}
| Name = 8-oxoguanine DNA glycosylase
| HGNCid = 8125
| Symbol = OGG1
| AltSymbols =; HMMH; HOGG1; MUTM; OGH1
| OMIM = 601982
| ECnumber =
| Homologene = 1909
| MGIid = 1097693
| GeneAtlas_image1 = PBB_GE_OGG1_205301_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_OGG1_205760_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0008534 |text = oxidized purine base lesion DNA N-glycosylase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}} {{GNF_GO|id=GO:0016829 |text = lyase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4968
| Hs_Ensembl = ENSG00000114026
| Hs_RefseqProtein = NP_002533
| Hs_RefseqmRNA = NM_002542
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 9765705
| Hs_GenLoc_end = 9783421
| Hs_Uniprot = O15527
| Mm_EntrezGene = 18294
| Mm_Ensembl = ENSMUSG00000030271
| Mm_RefseqmRNA = NM_010957
| Mm_RefseqProtein = NP_035087
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 113292779
| Mm_GenLoc_end = 113299963
| Mm_Uniprot = Q3UIL3
}}
}}
'''8-oxoguanine DNA glycosylase''', also known as '''OGG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization.<ref>{{cite web | title = Entrez Gene: OGG1 8-oxoguanine DNA glycosylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4968| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Boiteux S, Radicella JP |title=The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. |journal=Arch. Biochem. Biophys. |volume=377 |issue= 1 |pages= 1-8 |year= 2000 |pmid= 10775435 |doi= 10.1006/abbi.2000.1773 }}
*{{cite journal | author=Park J, Chen L, Tockman MS, ''et al.'' |title=The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk. |journal=Pharmacogenetics |volume=14 |issue= 2 |pages= 103-9 |year= 2004 |pmid= 15077011 |doi= }}
*{{cite journal | author=Hung RJ, Hall J, Brennan P, Boffetta P |title=Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. |journal=Am. J. Epidemiol. |volume=162 |issue= 10 |pages= 925-42 |year= 2006 |pmid= 16221808 |doi= 10.1093/aje/kwi318 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on RAN... {November 3, 2007 5:04:23 PM PDT}
UPLOAD: Added new Image to wiki: {November 3, 2007 5:08:28 PM PDT}
AMBIGUITY: Did not locate an acceptable page to update. {November 3, 2007 5:08:45 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RAN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a2k.
| PDB = {{PDB2|1a2k}}, {{PDB2|1byu}}, {{PDB2|1i2m}}, {{PDB2|1ibr}}, {{PDB2|1k5d}}, {{PDB2|1k5g}}, {{PDB2|1qbk}}, {{PDB2|1qg2}}, {{PDB2|1qg4}}, {{PDB2|1rrp}}, {{PDB2|1wa5}}, {{PDB2|2bku}}, {{PDB2|3ran}}
| Name = RAN, member RAS oncogene family
| HGNCid = 9846
| Symbol = RAN
| AltSymbols =; ARA24; Gsp1; TC4
| OMIM = 601179
| ECnumber =
| Homologene = 68143
| MGIid = 1333112
| GeneAtlas_image1 = PBB_GE_RAN_200750_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAN_200749_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0000178 |text = exosome (RNase complex)}} {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0006405 |text = RNA export from nucleus}} {{GNF_GO|id=GO:0006606 |text = protein import into nucleus}} {{GNF_GO|id=GO:0006611 |text = protein export from nucleus}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007052 |text = mitotic spindle organization and biogenesis}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5901
| Hs_Ensembl = ENSG00000132341
| Hs_RefseqProtein = NP_006316
| Hs_RefseqmRNA = NM_006325
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 129922521
| Hs_GenLoc_end = 129927316
| Hs_Uniprot = P62826
| Mm_EntrezGene = 19384
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009391
| Mm_RefseqProtein = NP_033417
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''RAN, member RAS oncogene family''', also known as '''RAN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.<ref>{{cite web | title = Entrez Gene: RAN RAN, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5901| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138-43 |year= 1998 |pmid= 9562972 |doi= }}
*{{cite journal | author=Budhu AS, Wang XW |title=Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1. |journal=Cell Cycle |volume=4 |issue= 11 |pages= 1510-4 |year= 2007 |pmid= 16294017 |doi= }}
}}
{{refend}}
{{protein-stub}}