NONMEM is a software package developed by Stuart L. Beal and Lewis B. Sheiner in the late 1970s at UCSF. Its name is an acronym for non-linear mixed effects modeling but it is used most in the context of Population pharmacokinetics, Pharmacometrics, and PK/PD models.[1][2][3][4]. NONMEM models are written in NMTRAN,a dedicated model specification language that is translated into FORTRAN, compiled on the fly and executed by a command-line script. Results are presented as text output files including tables. [5] There are multiple interfaces to assist modelers with housekeeping of files, tracking of model development, goodness-of-fit evaluations and graphical output, such as PsN and xpose and Wings for NONMEM.
References edit
- ^ Sheiner, Lewis B.; B. Rosenberg; V.V. Marathe (1977). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters I. Michaelis-Menten Model: Routine Clinical Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics. 5 (5): 445–79. doi:10.1007/BF01061728. PMID 925881. S2CID 28622472.
- ^ Sheiner, Lewis B.; Stuart L. Beal (1980). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters I. Michaelis-Menten Model: Routine Clinical Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics. 8 (6): 553–71. doi:10.1007/BF01060053. PMID 7229908. S2CID 31174590.
- ^ Sheiner, Lewis B.; Stuart L. Beal (1981). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters II. Biexponential Model and Experimental Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics. 9 (5): 635–51. doi:10.1007/BF01061030. PMID 7334463. S2CID 2668816.
- ^ Sheiner, Lewis B.; Stuart L. Beal (1983). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters III. Monoexponential Model: Routine Clinical Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics. 11 (3): 303–19. doi:10.1007/BF01061870. PMID 6644555. S2CID 9308691.
- ^ Bauer, Robert J. (2019). "NONMEM Tutorial Part I: Description of Commands and Options, With Simple Examples of Population Analysis". CPT: Pharmacometrics & Systems Pharmacology. 8 (8): 525–537. doi:10.1002/psp4.12404. ISSN 2163-8306. PMC 6709426. PMID 31056834.
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