Wikipedia

User:Ongmianli/PBD Portfolio

< User:Ongmianli

Pediatric bipolar disorder (description, assessment and diagnosis) edit

Pediatric Bipolar Disorder

Identifying bipolar disorder in children is challenging at any age because youth diagnosed with bipolar disorder frequently have depressive and manic symptoms that occur daily, and sometimes simultaneously.[1]

Therefore, the purpose of this page is to provide an up to date resource for clinicians on pediatric bipolar disorder (PBD) with regard to base rates, recommended diagnostic interviews, screening instruments, process/outcome measures, change benchmarks of clinical significance and resources available online and in the community.

Overview edit

Pediatric bipolar disorder (PBD) is characterized by extreme fluctuations in mood or emotional dysregulation that ranges from mania (as shown by displays or feelings of extreme happiness, unrealistic overachievement and anger), to depression (as shown by displays or feelings of sadness, changes in appetite or weight and irritability[2] [3]. It is important to note that these moods exceed normal responses to life events, represent a change from the individual's normal functioning, and cause problems in daily activities. These mood fluctuations result in a child finding it difficult to live with family, friends and teachers when it was previously not an issue[2].

Diagnostic criteria edit

Diagnostic changes edit

The diagnostic criteria for bipolar disorders changed slightly from DSM-IV to DSM-5. Summaries are available here and here.

Description edit

People with bipolar disorder experience unusually intense emotional states that occur in distinct periods called "mood episodes". An overly joyful or overexcited state is called a manic episode, and an extremely sad or hopeless state is called a depressive episode. Sometimes, a mood episode includes symptoms of both mania and depression.

People with bipolar disorder also may be explosive and irritable during a mood episode.[2] Extreme changes in energy, activity, sleep, and behavior go along with these changes in mood. It is possible for someone with bipolar disorder to experience a long-lasting period of unstable moods rather than discrete episodes of depression or mania.[3] [2]. A person may be having an episode of bipolar disorder if he or she has a number of manic or depressive symptoms for most of the day, nearly every day, for at least one or two weeks. These debilitating symptoms can result in an afflicted individual to be unable to function adaptively in several settings.

Demographic information edit

This section describes the demographic setting of the population(s) sampled, base rates of diagnosis, country/region sampled and the diagnostic method that was used. Using this information, clinicians will be able to anchor the rate of PBD that they are likely to see in their clinical practice.

Base rates in different clinical settings edit

Setting Reference Base Rate Demography Diagnostic Method
National Comorbidity Survey-Adolescent

(NCS-A)

Kessler et al., 2012[4] 3.0% All of U.S.A. Composite International Diagnostic Interview (CIDI) 3.0
Community epidemiologic samples Van Meter, Moreira, & Youngstrom, 2011[5] 1.2% U.S.A., Netherlands, U.K., Spain, Mexico, Ireland, New Zealand Structured and semi-structured diagnostic interviews
Community mental health center Youngstrom et. al, 2005 6% U.S.A., Midwestern Urban, 80% non-white, low-income Parent and youth clinical assessment & treatment
General outpatient clinic Geller et al., 2002 6-8% Urban academic research centers WASH-U-KSADS (parent and youth)
Specialty outpatient service Biederman et al., 1996 15-17% New England.. U. S. A. KSADS-E
Inpatient Services/Diagnoses Holtmann et al., 2008 0.3% All of Germany International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10)
Community sample Olino et al., 2012[6] 2.9% Oregon LIFE, SCID, DSM-IV
Inpatient service Carlson & Youngstrom, 2003[7] 30% manic symptoms, <2% strict BP I New York City Metro Region DICA; KSADS
  • KSADS = Kiddie Schedule for Affective Disorders and Schizophrenia,
  • WASH-U = Washington University version, -PL = Present and Lifetime Version, -E = Epidemiological version of the KSADS
  • LIFE = Longitudinal Interval Follow-Up Evaluation,
  • DICA = Diagnostic Interview for Children and Adolescents

Brief screening tools edit

The following are brief screening tools that typically takes less than 5 minutes to administer to accurately diagnose pediatric bipolar disorder:

7 Up 7 Down Inventory (7U7D) edit

The 7 Up 7 Down Inventory[8] is a recently developed and validated questionnaire with 14 items of manic and depressive tendencies carved from the General Behavior Inventory, a well-validated but cumbersome interview. For both mania and depression factors, 7 items produced a psychometrically adequate measure applicable across both aggregate samples. Internal reliability of the Mania scale was .81 (youth) and .83 (adult) and for Depression was .93 (youth) and .95 (adult).

The 7 Up 7 Down Inventory, along with the accompanying research article can be found here.

PGBI-10M edit

The PGBI-10M is a brief (10 item) instrument derived from the Parent General Behavior Inventory (P-GBI) , a 73-item mood inventory, to assess mania in a large sample of outpatients presenting with a variety of different DSM-IV diagnoses, including frequent comorbid conditions.[9]

The 10-item GBI derived from the 73-item P-GBI had good reliability (alpha = .92), correlated (r = 0.95) with the 28-item scale, and showed significantly better discrimination of bipolar disorders (area under the receiver operating characteristic [AUROC] curve of 0.856 vs. 0.832 for the 28-item scale, p < .005). The 10-item scale also did well discriminating bipolar from unipolar (AUROC = 0.86) and bipolar from attention-deficit/hyperactivity disorder (AUROC = 0.82) cases.

The full version of the scale, the Parent-General Behavior Inventory (P-GBI) is a parent report measure of depressive and hypomanic/biphasic symptoms adapted from the General Behavior Inventory (GBI).

Classification rates exceed 80%, and receiver operating characteristic analyses showed good diagnostic efficiency for the scales, with areas under the curve greater than .80. Results indicate that clinicians can use the parent-completed GBI to derive clinically meaningful information about mood disorders in youths.

Gold standard diagnostic interviews edit

Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime (KSADS-PL) edit

The Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime (KSADS-PL) is a semi-structured diagnostic interview that assesses current and past Diagnostic and Statistical Manual of Mental Disorders – Fourth Edition (DSM-IV-TR) Axis I psychopathology in youth[2]. The KSADS-PL diagnostic interviews have good inter-rater (.93 to 1.00) and retest reliability (.77) for mood disorders [10] Here is a link to a PDF of the diagnostic interview for the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime.

Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) edit

The Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia(WASH-U-KSADS)[11] was expanded from the 1986 version of the KSADS, which was modified and expanded to include onset and offset of each symptom for both current and lifetime episodes, expanded prepubertal mania and rapid cycling sections, and categories for attention deficit hyperactivity disorder and other DSM-IV diagnoses. To optimize diagnostic research, skip-outs were minimized.

The kappa values of comparisons between research nurse and off-site blind best-estimate ratings of mania and rapid cycling sections were excellent (0.74-1.00). High 6-month stability for mania diagnoses (85.7%) and for individual mania items and validity against parental and teacher reports were previously reported.[11]

The link to the diagnostic interview for the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia can be found here.

Interpretation of screening scores edit

Overview edit

The purpose of this subsection is to use Baynesian probability theory in order to accurately predict the diagnosis of pediatric bipolar disorder, given base diagnosis rate in the region and diagnostic likelihood ratios.

Area under curve (AUC) edit

The area under the curve (AUC, or AUROC) is equal to the probability that a classifier will rank a randomly chosen positive diagnosis of PBD higher than a randomly chosen negative diagnosis of PBD.

Likelihood ratios edit

Likelihood ratios (also known as likelihood ratios in diagnostic testing) are the proportion of cases with the diagnosis scoring in a given range divided by the proportion of the cases without the diagnosis scoring in the same range.[12][13] The table below shows area under the curve (AUCs) and likelihood ratios for potential screening measures for pediatric bipolar disorder. It should be noted that all studies used some version of a K-SADS interview by a trained rater, combined with review by a clinician to establish consensus.

Likelihood Ratio Comments
Larger than 10, smaller than 0.10 Frequently clinically decisive
Ranging from 5 to 10, 0.20 Helpful in clinical diagnosis
Between 2.0 and 0.5 Rarely result in clinically meaningful changes of formulation
Around 1.0 Test result did not change clinical impressions at all

"LR+" refers to the change in likelihood ratio associated with a positive test score, and "LR-" is the likelihood ratio for a low score. Likelihood ratios of 1 indicate that the test result did not change impressions at all. On the other hand, likelihood ratios larger than 10 or smaller than 0.10 are frequently clinically decisive, 5 or 0.20 are helpful, and between 2.0 and .5 are small enough that they rarely result in clinically meaningful changes of formulation.

Area under curve (AUCs) and likelihood ratios edit

The following table describes the diagnostic likelihood ratios and area under curves for the top pediatric bipolar disorder measures.

Screening Measure Lower risk range DLR- Higher risk range DLR+ Population AUC (sample size) Citation
Parent General Behavior Inventory

(P-GBI) (Hypomanic/Biphasic Section)

Above 49, below 9 .06 49+ 9.2 Bipolar spectrum vs. all other diagnoses .84 (324) Youngstrom, Findling, Calabrese et al., 2004[14]
Parent Mood Disorder Questionnaire

(P-MDQ)

Above 6, below 9-WTF? .17 xxx 4.6 Bipolar spectrum vs. all other diagnoses .84 (819) Wagner et al., 2006[15]
Child Mania Rating Scale (Brief)

(Brief CMRS-P)

<11 .17 11+ 10.5 Bipolar spectrum vs. ADHD .85 (150) Henry et al., 2008[16]
Child Mania Rating Scale (Full)

(Full CMRS-P)

<21 .19 21+ 13.7 Bipolar spectrum vs. ADHD .91 (150) Henry et al., 2008[16]

Clinically significant change benchmarks edit

Listed below are clinically significant change benchmarks of common screening instruments used for pediatric bipolar disorder.

Measure Subscale Cut-off scores Critical Change
(unstandardized scores)
Benchmarks Based on Published Norms
A B C 95% 90% SEdifference
Beck Depression Inventory[17] BDI Mixed Depression 4 22 15 9 8 4.8
CBCL T-scores
(2001 Norms) 		Total 49 70 58 5 4 2.4
Externalizing 49 70 58 7 6 3.4
Internalizing n/a 70 56 9 7 4.5
Attention Problems n/a 66 58 8 7 4.2
TRF T-scores
(2001 Norms) 		Total n/a 70 57 5 4 2.3
Externalizing n/a 70 56 6 5 3.0
Internalizing n/a 70 55 9 7 4.4
Attention Problems n/a 66 57 5 4 4.8
YSR T-scores
(2001 Norms) 		Total n/a 70 54 7 6 3.3
Externalizing n/a 70 54 9 8 4.6
Internalizing n/a 70 54 9 8 4.8
Benchmarks Based on Bipolar Spectrum Samples
Gracious et al., 2002[18]
Young Mania Rating Scale - Parent
(Full) 		n/a 5.2 22.1 14.4 4.3 3.6 2
Young Mania Rating Scale - Parent
(Brief) 		n/a 6.8 27.4 17.5 5 4.2 2.5
Carlson & Youngstrom, 2003>[19]
Teacher-Completed Teacher Self-Control Rating Scale n/a 32.4 110.6 72.6 11.6 9.7 5.75
Inpatient Global Rating Scales n/a 1.9 90.7 50.8 15.7 13.2 7.21
Cooperberg, 2002
Young Mania Rating Scale (Clinician Rated) n/a 6 2 2 12 10 6.2
Child Depression Rating-Revised (CDRS-R) n/a n/a 40 29 8 7 4
Parent GBI Hypomanic/Biphasic 7 19 15 8 7 4.2
Depression n/a 18 13 7 6 3.6
Adolescent GBI Hypomanic/Biphasic n/a 32 19 8 7 4.4
Depression n/a 47 27 10 9 5.2

Treatments edit

Wikipedia has a page reviewing treatments for bipolar disorder (Treatment_of_bipolar_disorder -- need to figure out if links need to be formatted as internal or external, depending on where we host this). Effective Child Therapy provides a curated list of effective psychosocial treatments for bipolar disorder in youths.

Community resources edit

  • National Alliance on Mental Illness - the nation’s largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI advocates for access to services, treatment, supports and research and is steadfast in its commitment to raise awareness and build a community for hope for all of those in need.[20]
  • Balanced Mind Foundation – information, articles, parent support chat rooms.[21]
  • Effective Child Therapy – Information and articles curated by Society of Clinical Child and Adolescent Psychology (SCCAP), a division of the American Psychological Association.[22]
  • International Bipolar Foundation - Information, help and resources available for caregivers and those afflicted with bipolar disorder.[23]
  • Bipolar Network News - an online clearinghouse and information on latest treatments, research and psychoeducation about mood disorders[24]
  • Depression Alliance - a United Kingdom charity that works to prevent and relieve depression by providing information and support services via supporter services, publications and self-help groups.[25]
  • Depression and Bipolar Support Alliance (DBSA) - a peer-directed national organization that provides links to resources, support groups, and peer support for individuals and their families suffering from bipolar disorder.

See also edit

References edit

  1. ^ Merikangas, Kathleen R.; Jin, Robert; He, Jian-Ping; Kessler, Ronald C.; Lee, Sing; Sampson, Nancy A.; Viana, Maria Carmen; Andrade, Laura Helena; Hu, Chiyi; Karam, Elie G.; Ladea, Maria; Mora, Maria Elena Medina; Browne, Mark Oakley; Ono, Yutaka; Posada-Villa, Jose; Sagar, Rajesh; Zarkov, Zahari (1 March 2011). "Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative". Archives of general psychiatry. 68 (3): 241–251. doi:10.1001/archgenpsychiatry.2011.12. ISSN 0003-990X. Retrieved 26 January 2016.
  2. ^ a b c d e American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
  3. ^ a b Goodwin, F. K., & Jamison, K. R. (2007). Manic-depressive illness. (10th edition). New York, NY: Oxford University Press
  4. ^ Kessler, Ronald C.; Avenevoli, Shelli; Costello, E. Jane; Georgiades, Katholiki; Green, Jennifer Greif; Gruber, Michael J.; He, Jian-ping; Koretz, Doreen; McLaughlin, Katie A.; Petukhova, Maria; Sampson, Nancy A.; Zaslavsky, Alan M.; Merikangas, Kathleen Ries (1 April 2012). "Prevalence, persistence, and sociodemographic correlates of DSM-IV disorders in the National Comorbidity Survey Replication Adolescent Supplement". Archives of General Psychiatry. 69 (4): 372–380. doi:10.1001/archgenpsychiatry.2011.160. ISSN 1538-3636. Retrieved 26 January 2016.
  5. ^ Van Meter, Anna R.; Moreira, Ana Lúcia R.; Youngstrom, Eric A. (1 September 2011). "Meta-analysis of epidemiologic studies of pediatric bipolar disorder". The Journal of Clinical Psychiatry. 72 (9): 1250–1256. doi:10.4088/JCP.10m06290. ISSN 1555-2101.
  6. ^ Olino, Thomas M.; Shankman, Stewart A.; Klein, Daniel N.; Seeley, John R.; Pettit, Jeremy W.; Farmer, Richard F.; Lewinsohn, Peter M. (1 September 2012). "Lifetime rates of psychopathology in single versus multiple diagnostic assessments: Comparison in a community sample of probands and siblings". Journal of psychiatric research. 46 (9): 1217–1222. doi:10.1016/j.jpsychires.2012.05.017. ISSN 0022-3956.
  7. ^ Carlson, Gabrielle A.; Youngstrom, Eric A. (1 June 2003). "Clinical implications of pervasive manic symptoms in children". Biological Psychiatry. 53 (11): 1050–1058. ISSN 0006-3223.
  8. ^ Youngstrom, Eric A.; Murray, Greg; Johnson, Sheri L.; Findling, Robert L. (1 December 2013). "The 7 up 7 down inventory: a 14-item measure of manic and depressive tendencies carved from the General Behavior Inventory". Psychological Assessment. 25 (4): 1377–1383. doi:10.1037/a0033975. ISSN 1939-134X.
  9. ^ Youngstrom, E. A.; Findling, R. L.; Danielson, C. K.; Calabrese, J. R. (1 June 2001). "Discriminative validity of parent report of hypomanic and depressive symptoms on the General Behavior Inventory". Psychological Assessment. 13 (2): 267–276. ISSN 1040-3590.
  10. ^ Kaufman, J.; Birmaher, B.; Brent, D.; Rao, U.; Flynn, C.; Moreci, P.; Williamson, D.; Ryan, N. (1 July 1997). "Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data". Journal of the American Academy of Child and Adolescent Psychiatry. 36 (7): 980–988. doi:10.1097/00004583-199707000-00021. ISSN 0890-8567.
  11. ^ a b Geller, B.; Zimerman, B.; Williams, M.; Bolhofner, K.; Craney, J. L.; DelBello, M. P.; Soutullo, C. (1 April 2001). "Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections". Journal of the American Academy of Child and Adolescent Psychiatry. 40 (4): 450–455. doi:10.1097/00004583-200104000-00014. ISSN 0890-8567.
  12. ^ Youngstrom, Eric A. (1 January 2013). "Future directions in psychological assessment: combining evidence-based medicine innovations with psychology's historical strengths to enhance utility". Journal of Clinical Child and Adolescent Psychology. 42 (1): 139–159. doi:10.1080/15374416.2012.736358. ISSN 1537-4424.
  13. ^ Strauss, S. E., Glasziou, P., Richardson, W. S., & Haynes, R. B. (2011). Evidence-based medicine: How to practice and teach EBM (4th ed.). New York, NY: Churchill Livingstone.
  14. ^ Youngstrom, E. A., Findling, R. L., & Calabrese, J. R. (2004). Effects of adolescent manic symptoms on agreement between youth, parent, and teacher ratings of behavior problems. Journal of Affective Disorders, 82, S5-S16.
  15. ^ Wagner, Karen Dineen; Hirschfeld, Robert M. A.; Emslie, Graham J.; Findling, Robert L.; Gracious, Barbara L.; Reed, Michael L. (1 May 2006). "Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescents". The Journal of Clinical Psychiatry. 67 (5): 827–830. ISSN 0160-6689.
  16. ^ a b Henry, David B.; Pavuluri, Mani N.; Youngstrom, Eric; Birmaher, Boris (1 April 2008). "Accuracy of brief and full forms of the Child Mania Rating Scale". Journal of Clinical Psychology. 64 (4): 368–381. doi:10.1002/jclp.20464. ISSN 0021-9762.
  17. ^ Beck, AT (1988). "Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation". Clinical Psychology Review. 8 (1). Retrieved 10 February 2014.
  18. ^ Gracious, Barbara L.; Youngstrom, Eric A.; Findling, Robert L.; Calabrese, Joseph R. (1 November 2002). "Discriminative validity of a parent version of the Young Mania Rating Scale". Journal of the American Academy of Child and Adolescent Psychiatry. 41 (11): 1350–1359. doi:10.1097/00004583-200211000-00017. ISSN 0890-8567.
  19. ^ Carlson, Gabrielle A.; Youngstrom, Eric A. (1 June 2003). "Clinical implications of pervasive manic symptoms in children". Biological Psychiatry. 53 (11): 1050–1058. ISSN 0006-3223.
  20. ^ NAMI: National Alliance on Mental Illness. "National Alliance on Mental Illness". Retrieved 5 February 2014.
  21. ^ The Balanced Mind. "The Balanced Mind Parent Network". Retrieved 5 February 2014.
  22. ^ Effective Child Therapy. "Effective Child Therapy: Evidence-based mental health treatment for children and adolescents". Retrieved 5 February 2014.
  23. ^ http://ibpf.org/resources, International Bipolar Foundation, retrieved 27th January 2014.
  24. ^ http://bipolarnews.org/, Bipolar Network News, retrieved 30th January 2014.
  25. ^ Depression Alliance, http://www.depressionalliance.org/, retrieved 30th January 2014.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Ongmianli/PBD_Portfolio&oldid=970729270"