Mayank Arora / Abeer Singh Godhwani as Kairav Goenka: Naira and Kartik's son; Abhira's brother; Vansh and Aarohi's half brother; Anisha's ex-fiancé (2021–2023)
Krishiv Mutha / Shaurya Shah / Tanmay Shah / Aarambh Trehan as Child Kairav Goenka (2019)
Samridhii Shukla Pranali Rathod / as Dr. Abhira "Sirat" Goenka Poddar: Naira and Kartik's daughter; Kairav's sister; Vansh and Aarohi's half-sister; Abhinav's widow; Abhimanyu's ex-wife; Armaan's wife; Abhir's mother (2021–2024)
Prachi Thakur as Child Abhira Goenka (2021)
Kairav Waghela as Baby Abhira Goenka (2020–2021)
Shreyansh Kaurav as Abhir Poddar: Abhira and Armaan's son (2023)
Sudhanshu Pandey as Vanraj "V" Shah: Leela and Hasmukh's son; Dolly's brother; Ritika's former boyfriend; Anupamaa's ex-husband; Kavya's second husband; Paritosh and Paakhi's father; Mahi and Samar's step-father; Aarya and Ishani's adoptive grandfather (2020–present)
Puja Banerjee as Ritika: Ravi's wife; Vanraj's former girlfriend; Paritosh and Paakhi's mother; Aarya and Ishani's adoptive grandmother (2022)
Aashish Mehrotra / Gaurav Sharma as Paritosh "Toshu" Shah: Ritika and Vanraj's elder son; Kavya's step-son; Paakhi's brother; Mahi and Samar's step-brother; Aadhya and Bhairavi's foster brother; Meenali's cousin; Kinjal's husband (2020–2024) / (2024–present)
Dheer Bhanushali as Child Paritosh Shah (2022)
Nidhi Shah as Kinjal "Kinju" Dave Shah: Rakhi and Pramod's daughter; Paritosh's wife (2020–present)
Harbandna Kaur / Chandni Bhagwanani / Kaveri Priyam as Paakhi "Sweety" Shah: Ritika and Vanraj's daughter; Kavya's step-daughter; Paritosh's sister; Mahi and Samar's step-sister; Aadhya's foster sister; Meenali's cousin; Adhik's ex-wife; Aarya and Ishani's adoptive mother; Tapesh's obsessive lover (2020–present)
Kunwar Amar as Tapesh aka Titu: A dancer and former teacher at Anupamaa Dance Academy; Dimple's love interest; Paakhi's husband; Aarya and Ishani's adoptive father (2023–present)
Princy Prajapati / Yukti Kapoor as Aarya "Pari" "Angel" Shah: Paakhi and Tapesh's adoptive first daughter; Ishani's adoptive sister (2024–present)
Aadhya Barot / Chandani Sharma as Ishani Shah: Pakhi and Tapesh's second adoptive daughter; Aarya's adoptive sister (2024–present)
Madalsa Sharma as Kavya Shah: Nandini's aunt; Aniruddh's ex-wife; Vanraj's second wife; Mahi and Samar's mother; Paritosh and Pakhi's step-mother; Aarya and Ishani's adoptive step-grandmother (2020–present)
Pahal Chaudhary / Kreetika Sharma / Tanya Sharma as Mahi Gandhi: Kavya and Aniruddh's daughter; Samar's sister; Vanraj's step-daughter; Paritosh and Pakhi's step-sister; Nandini's cousin; Meenali's step-cousin; Adhik (2024–present)
Adhik Mehta as Adhik Mehta: Barkha's brother; Ankush and Barkha's foster son; Sara’s uncle and foster brother; Paakhi's ex-husband; Mahi's husband; Ansh's father (2022–Present)
Trishaan Shah as Ansh Mehta: Mahi and Adhik's son (2023–present)
Paras Kalnawat / Sagar Parekh as Samar Shah: Kavya and Aniruddh's son; Mahi's brother; Paritosh and Paakhi's brother; Aadhya's foster brother; Meenali's cousin; Nandini's ex-fiancé; Dimple's husband (2020–2024)
Vidvaan Sharma as Child Samar Shah (2022)
Nishi Saxena as Dimple "Dimpy" Shah: Teacher and Owner of Anupamaa Dance Academy; Nirmit's ex-wife; Samar's widow (2022–present)
Ekta Saraiya as Dolly Shah Dhamecha: Leela and Hasmukh's daughter; Vanraj's sister; Sanjay's wife; Meenali's mother (2020–2023)
Muskaan Bamne / Surbhi Chandna as Meenali "Meenu" Dhamecha: Dolly and Sanjay's daughter; Paritosh and Paakhi's cousin; Mahi and Samar's step-cousin (2024)
Gaurav Khanna as Anuj "AK" Kapadia: Business tycoon and Event Manager; Malti's son; Gopichand's foster son; Malvika's adopted brother; Ankush's adopted cousin; Anupamaa's ex-husband; Shruti's fiancé; Sara, Aadhya and Bhairavi's foster father (2021–present)
Naksh Dhaval Adhyaru as Child Anuj Kapadia (2022)
Ashlesha Sawant as Barkha Kapadia: Adhik's sister and foster mother; Ankush's wife; Sara's mother; Romil's step-mother (2022–2023)
Shrenu Parikh as Sara Kapadia: Ankush and Barkha's daughter; Adhik's niece and foster sister; Romil's half-sister; Ansh's cousin; Aadhya's foster cousin (2022)
Chhavi Pandey as Maya: Priest's daughter; an unwilling former prostitute; Aadhya's mother; Anuj's former obsessive one-sided lover (2023)
