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Pronunciation | Vismodegib /ˌvɪsmoʊˈdɛɡɪb/ VIS-moh-DEG-ib Erivedge /ˈɛrɪvɛdʒ/ ERR-i-vej |
Trade names | Erivedge |
Other names | GDC-0449, RG-3616 |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth (capsules) |
Drug class | Hedgehog pathway inhibitor[2] |
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Pharmacokinetic data | |
Bioavailability | 31.8% |
Protein binding | >99% |
Metabolism | <2% metabolised by CYP2C9, CYP3A4, CYP3A5 |
Elimination half-life | 4 days (continuous use), 12 days (single dose) |
Excretion | Fecal (82%), Urinary (4.4%) |
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Chemical and physical data | |
Formula | C19H14Cl2N2O3S |
Molar mass | 421.29 g·mol−1 |
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Vismodegib, sold under the brand name Erivedge, is a medication used to treat basal-cell cancer (BCC).[3] Specifically it is used in those in who the cancer has spread or has recurred and cannot be treated by other methods.[3] It is taken by mouth.[3]
Common side effects include hair loss, tiredness, nausea, and muscle spasms.[3] Use during pregnancy may harm the baby.[3] Effective birth control is recommended for both men and women.[3] It is a hedgehog pathway inhibitor.[2]
Vismodegib was approved for medical use in the United States in 2012 and Europe in 2013.[3][4] In the United States it costs about 12,300 USD per month as of 2021 and is only available through specialty pharmacies.[3][5] In the United Kingdom this amount costs the NHS about £6,300.[2]
References
edit- ^ a b FDA Professional Drug Information
- ^ a b c d BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1066. ISBN 978-0-85711-369-6.
{{cite book}}
: CS1 maint: date format (link) - ^ a b c d e f g h i j "Vismodegib Monograph for Professionals". Drugs.com. Archived from the original on 22 March 2016. Retrieved 15 September 2021.
- ^ a b "Erivedge". Archived from the original on 13 August 2021. Retrieved 16 September 2021.
- ^ "Erivedge Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 5 September 2015. Retrieved 16 September 2021.