Uveitis | |
---|---|
Inflammation of the eye and keratic precipitates due to uveitis | |
Pronunciation | |
Specialty | Ophthalmology |
Symptoms | Blurry vision, floaters, eye pain, red eye, sensitivity to light[1] |
Complications | Vision loss, glaucoma[1][2] |
Usual onset | Sudden[1] |
Types | Anterior, intermediate, posterior[1] |
Causes | Infection: Cytomegalovirus, histoplasmosis, shingles, toxoplasmosis[1] Autoimmune: Behcet’s disease, psoriasis, ulcerative colitis, lupus[1] |
Risk factors | Cigarette smoking[1] |
Diagnostic method | Based on symptoms and eye exam[1] |
Differential diagnosis | Retinoblastoma, lymphoma, glaucoma[2] |
Treatment | Steroids, atropine, underlying cause[3][2] |
Prognosis | Usually good with treatment[3] |
Frequency | 1 in 3,000 per year[4] |
Uveitis is inflammation inside the eye.[1] Onset is usually sudden.[1] Early symptoms include blurry vision, floaters, eye pain, red eye, and sensitivity to light.[1] One or both eyes may be affected.[1] Complications may include loss of vision and glaucoma.[1][2]
Causes may be unknown, eye infection, or autoimmune conditions.[1][4] Risk factors include cigarette smoking.[1] The uvea is the iris, ciliary body, and choroid.[1] It is divided into anterior, intermediate, and posterior uveitis; though in panuveitis all parts may be affected.[1] Diagnosis is based on symptoms and a dilated eye exam.[1]
Treatment is usually with steroids, most commonly as eye drops such as prednisolone.[1][5] In severe cases steroids by mouth or by injection may be used.[5] If steroids are not effective other immunosuppressants such as methotrexate may be used.[5] Cycloplegics, such as atropine, may be used to help with pain and prevent complications.[3] In cases due to infection, specific treatment for the infection is also required.[2]
Uveitis affects about 1 in 3,000 people per year.[4] It most commonly occurs in those between the ages of 20–60; though any age may be affected.[1] Males and females are affected at similar rates.[4] It accounts for about 5-10% of vision problems globally and is the cause of up to 25% of blindness in the developing world.[4] With appropriate treatment outcomes are usually good.[3]
References
edit- ^ a b c d e f g h i j k l m n o p q r s t "Uveitis | National Eye Institute". www.nei.nih.gov. Archived from the original on 3 December 2021. Retrieved 21 January 2022.
- ^ a b c d e Gueudry, J; Muraine, M (January 2018). "Anterior uveitis". Journal francais d'ophtalmologie. 41 (1): e11–e21. doi:10.1016/j.jfo.2017.11.003. PMID 29290458.
- ^ a b c d Duplechain, A; Conrady, CD; Patel, BC; Baker, S (January 2022). "Uveitis". PMID 31082037.
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(help) - ^ a b c d e Tsirouki, T; Dastiridou, A; Symeonidis, C; Tounakaki, O; Brazitikou, I; Kalogeropoulos, C; Androudi, S (2018). "A Focus on the Epidemiology of Uveitis". Ocular immunology and inflammation. 26 (1): 2–16. doi:10.1080/09273948.2016.1196713. PMID 27467180.
- ^ a b c Gamalero, L; Simonini, G; Ferrara, G; Polizzi, S; Giani, T; Cimaz, R (July 2019). "Evidence-Based Treatment for Uveitis". The Israel Medical Association journal : IMAJ. 21 (7): 475–479. PMID 31507124.