User:Mr. Ibrahem/Triheptanoin

Mr. Ibrahem/Triheptanoin
Clinical data
Trade names	Dojolvi
Other names	UX007
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Triheptanoin;
Routes of; administration	By mouth
Drug class	Glycerolipids
Legal status
Legal status	CA: ℞-only; US: ℞-only;
Identifiers
	IUPAC name 2,3-di(heptanoyloxy)propyl heptanoate or glyceryl triheptanoate;
Chemical and physical data
Formula	C24H44O6
Molar mass	428.610 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCCC(=O)OCC(COC(=O)CCCCCC)OC(=O)CCCCCC;
	InChI InChI=1S/C24H44O6/c1-4-7-10-13-16-22(25)28-19-21(30-24(27)18-15-12-9-6-3)20-29-23(26)17-14-11-8-5-2/h21H,4-20H2,1-3H3 ; Key:PJHKBYALYHRYSK-UHFFFAOYSA-N ;

Triheptanoin, sold under the brand name Dojolvi, is a medication used to treat long-chain fatty acid oxidation disorders (LC-FAOD).^[2] This includes pyruvate carboxylase deficiency and carnitine palmitoyltransferase II deficiency.^[3]^[4] It is taken by mouth.^[2]

Common side effects include abdominal pain, diarrhea, vomiting, and nausea.^[2] In those with pancreatic insufficiency intestinal malabsorption may occur.^[2] It is a manufactured medium-chain triglyceride and is a source of calories and fatty acids.^[2]^[5]

Triheptanoin was approved for medical use in the United States in 2020.^[2] As of 2022 it is not approved in Europe or the United Kingdom.^[5] In the United States it costs about 5,600 USD for 500 ml as of 2022.^[6]

References

^ "Summary Basis of Decision (SBD) for Dojolvi". Health Canada. Archived from the original on 30 May 2022. Retrieved 29 May 2022.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Dojolvi- triheptanoin liquid". DailyMed. 30 June 2020. Archived from the original on 2 August 2021. Retrieved 24 September 2020.
^ "Pyruvate Carboxylase Deficiency". NORD (National Organization for Rare Disorders). Archived from the original on 23 October 2022. Retrieved 4 November 2022.
^ RESERVED, INSERM. "Orphanet: Carnitine palmitoyl transferase II deficiency, myopathic form". www.orpha.net. Archived from the original on 27 November 2021. Retrieved 4 November 2022.
^ ^a ^b "Triheptanoin". SPS - Specialist Pharmacy Service. 2 February 2018. Archived from the original on 31 January 2022. Retrieved 4 November 2022.
^ "Dojolvi Prices, Coupons, Copay & Patient Assistance". Drugs.com. Archived from the original on 16 September 2021. Retrieved 4 November 2022.

[1] "Summary Basis of Decision (SBD) for Dojolvi". Health Canada. Archived from the original on 30 May 2022. Retrieved 29 May 2022.

[PI2022-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Dojolvi- triheptanoin liquid". DailyMed. 30 June 2020. Archived from the original on 2 August 2021. Retrieved 24 September 2020.

[3] "Pyruvate Carboxylase Deficiency". NORD (National Organization for Rare Disorders). Archived from the original on 23 October 2022. Retrieved 4 November 2022.

[4] RESERVED, INSERM. "Orphanet: Carnitine palmitoyl transferase II deficiency, myopathic form". www.orpha.net. Archived from the original on 27 November 2021. Retrieved 4 November 2022.

[SPS2022-5] "Triheptanoin". SPS - Specialist Pharmacy Service. 2 February 2018. Archived from the original on 31 January 2022. Retrieved 4 November 2022.

[6] "Dojolvi Prices, Coupons, Copay & Patient Assistance". Drugs.com. Archived from the original on 16 September 2021. Retrieved 4 November 2022.

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