Clinical data | |
---|---|
Trade names | Aklief |
Other names | CD5789 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a620004 |
License data |
|
Pregnancy category |
|
Routes of administration | Topical |
Drug class | Retinoid[2] |
Legal status | |
Legal status | |
Identifiers | |
| |
Chemical and physical data | |
Formula | C29H33NO4 |
Molar mass | 459.586 g·mol−1 |
3D model (JSmol) | |
| |
|
Trifarotene, sold under the brand name Aklief, is a medication used for acne.[2] It is applied to the skin as a cream.[2] Moisturizer may also be used to help prevent irritation of the skin.[2]
Common side effects include itchiness, irritation, and easy sunburns.[2] There are concerns that use during pregnancy may harm the baby.[5] It is a retinoid; specifically a fourth generation selective retinoic acid receptor (RAR)-γ agonist.[2][6]
Trifarotene was approved for medical use in the United States, Canada, and Europe in 2019.[2][5] In the United States a 45 gram tube costs about 575 USD as of 2021.[7]
References
edit- ^ a b "Trifarotene Product Information". Therapeutic Goods Administration (TGA). Archived from the original on 23 May 2021. Retrieved 23 May 2021.
- ^ a b c d e f g h i "Trifarotene Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 19 September 2021.
- ^ "Archive copy" (PDF). Archived (PDF) from the original on 23 May 2021. Retrieved 26 June 2021.
{{cite web}}
: CS1 maint: archived copy as title (link) - ^ "Aklief- trifarotene cream". DailyMed. Archived from the original on 23 May 2021. Retrieved 22 May 2021.
- ^ a b "Australian Public Assessment Report for Trifarotene" (PDF). Archived (PDF) from the original on 23 September 2021. Retrieved 19 September 2021.
- ^ Scott LJ (November 2019). "Trifarotene: First Approval". Drugs. 79 (17): 1905–1909. doi:10.1007/s40265-019-01218-6. PMID 31713811. S2CID 207964653. Archived from the original on 29 August 2021. Retrieved 26 June 2021.
- ^ "Aklief Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 September 2021.