 | |
| Clinical data | |
|---|---|
| Trade names | Yondelis |
| Other names | ecteinascidin 743, ET-743 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a615059 |
| License data |
|
| Routes of administration | Intravenous |
| Drug class | Alkylating agent[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Not applicable (IV only) |
| Protein binding | 94 to 98% |
| Metabolism | Liver (mostly CYP3A4-mediated) |
| Elimination half-life | 180 hours (mean) |
| Excretion | Mostly fecal |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C39H43N3O11S |
| Molar mass | 761.84 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Trabectedin, sold under the brand name Yondelis, is a medication used to treat advanced soft-tissue sarcoma and ovarian cancer.[5] It is used when other treatments are no longer effective.[5] It is given by gradual injection into a vein.[5] Dexamethasone is used to decrease the risk of side effects.[1]
Common side effects include low neutrophils, nausea, liver problems, low red blood cells, tiredness, low platelets, and diarrhea.[5] Other side effects may include muscle breakdown, heart failure, and decreased fertility.[1] Use during pregnancy may harm the baby.[1] Death occurs due to the medication in 1 to 2% of people.[5] It is an alkylating agent.[1]
Trabectedin was approved for medical use in Europe in 2007 and the United States in 2015.[5][1] It was initially designated an orphan medicine in Europe in 2001.[5] In the United Kingdom 1 mg costs the NHS about £1,400 as of 2021.[6] In the United States this amount costs about 3,250 USD.[7] It was originally derived from a sea squirt.[5]
References
edit- ^ a b c d e f "Trabectedin Monograph for Professionals". Drugs.com. Retrieved 8 October 2021.
- ^ "Yondelis 1 mg powder for concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 21 September 2020. Archived from the original on 29 August 2021. Retrieved 30 September 2020.
- ^ "Yondelis- trabectedin injection, powder, lyophilized, for solution". DailyMed. 22 September 2020. Archived from the original on 25 October 2020. Retrieved 30 September 2020.
- ^ "Yondelis EPAR". European Medicines Agency (EMA). Archived from the original on 22 October 2020. Retrieved 30 September 2020.
- ^ a b c d e f g h i j "Yondelis". Archived from the original on 22 October 2020. Retrieved 8 October 2021.
- ^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 972. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ "Yondelis Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 26 January 2021. Retrieved 8 October 2021.