User:Mr. Ibrahem/Trabectedin

Mr. Ibrahem/Trabectedin
Clinical data
Trade names	Yondelis
Other names	ecteinascidin 743, ET-743
AHFS/Drugs.com	Monograph
MedlinePlus	a615059
License data	EU EMA: by INN; US DailyMed: Trabectedin;
Routes of; administration	Intravenous
Drug class	Alkylating agent
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	Not applicable (IV only)
Protein binding	94 to 98%
Metabolism	Liver (mostly CYP3A4-mediated)
Elimination half-life	180 hours (mean)
Excretion	Mostly fecal
Identifiers
	IUPAC name (1'R,6R,6aR,7R,13S,14S,16R)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydrospiro[6,16-(epithiopropano-oxymethano)-7,13-imino-6aH-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-5-yl acetate;
Chemical and physical data
Formula	C39H43N3O11S
Molar mass	761.84 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1cc2c(c(c1OC)O)[C@@H]3[C@@H]4[C@H]5c6c(c7c(c(c6OC(=O)C)C)OCO7)[C@@H](N4[C@H]([C@H](C2)N3C)O)COC(=O)[C@@]8(CS5)c9cc(c(cc9CCN8)O)OC;
	InChI InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1 ; Key:PKVRCIRHQMSYJX-AIFWHQITSA-N ;
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Trabectedin, sold under the brand name Yondelis, is a medication used to treat advanced soft-tissue sarcoma and ovarian cancer.^[5] It is used when other treatments are no longer effective.^[5] It is given by gradual injection into a vein.^[5] Dexamethasone is used to decrease the risk of side effects.^[1]

Common side effects include low neutrophils, nausea, liver problems, low red blood cells, tiredness, low platelets, and diarrhea.^[5] Other side effects may include muscle breakdown, heart failure, and decreased fertility.^[1] Use during pregnancy may harm the baby.^[1] Death occurs due to the medication in 1 to 2% of people.^[5] It is an alkylating agent.^[1]

Trabectedin was approved for medical use in Europe in 2007 and the United States in 2015.^[5]^[1] It was initially designated an orphan medicine in Europe in 2001.^[5] In the United Kingdom 1 mg costs the NHS about £1,400 as of 2021.^[6] In the United States this amount costs about 3,250 USD.^[7] It was originally derived from a sea squirt.^[5]

References

^ ^a ^b ^c ^d ^e ^f "Trabectedin Monograph for Professionals". Drugs.com. Archived from the original on 25 February 2024. Retrieved 8 October 2021.
^ "Yondelis 1 mg powder for concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 21 September 2020. Archived from the original on 29 August 2021. Retrieved 30 September 2020. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)
^ "Yondelis- trabectedin injection, powder, lyophilized, for solution". DailyMed. 22 September 2020. Archived from the original on 25 October 2020. Retrieved 30 September 2020. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)
^ "Yondelis EPAR". European Medicines Agency (EMA). Archived from the original on 22 October 2020. Retrieved 30 September 2020. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Yondelis". Archived from the original on 22 October 2020. Retrieved 8 October 2021. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)
^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 972. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ "Yondelis Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 26 January 2021. Retrieved 8 October 2021. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f "Trabectedin Monograph for Professionals". Drugs.com. Archived from the original on 25 February 2024. Retrieved 8 October 2021.

[2] "Yondelis 1 mg powder for concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 21 September 2020. Archived from the original on 29 August 2021. Retrieved 30 September 2020. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)

[Yondelis_FDA_label-3] "Yondelis- trabectedin injection, powder, lyophilized, for solution". DailyMed. 22 September 2020. Archived from the original on 25 October 2020. Retrieved 30 September 2020. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)

[Yondelis_EPAR-4] "Yondelis EPAR". European Medicines Agency (EMA). Archived from the original on 22 October 2020. Retrieved 30 September 2020. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)

[EPAR2021-5] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Yondelis". Archived from the original on 22 October 2020. Retrieved 8 October 2021. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)

[BNF80-6] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 972. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[7] "Yondelis Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 26 January 2021. Retrieved 8 October 2021. {{cite web}}: More than one of |archivedate= and |archive-date= specified (help); More than one of |archiveurl= and |archive-url= specified (help)

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