![]() | |
Clinical data | |
---|---|
Trade names | Vumon |
Other names | VM-26 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692045 |
Pregnancy category |
|
Routes of administration | Intravenous |
Drug class | Podophyllotoxin derivative[1] |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | N/A |
Protein binding | >99% |
Metabolism | Liver (CYP2C19-mediated) |
Elimination half-life | 5 hours |
Excretion | Kidney and fecal |
Identifiers | |
| |
Chemical and physical data | |
Formula | C32H32O13S |
Molar mass | 656.66 g·mol−1 |
3D model (JSmol) | |
| |
| |
![]() ![]() |
Teniposide, sold under the brand name Vumon, is a chemotherapy medication used to treat acute lymphocytic leukemia (ALL) in children.[1] It is a second line agent for this use.[1] Other uses may include small cell lung cancer and lymphoma.[2] It is given by injection into a vein.[1]
Common side effects include low white blood cells, low red blood cells, low platelets, inflammation in the mouth, nausea, hair loss, bleeding, fever, and allergic reactions.[1] Other side effects may include other cancers, tissue death at the site of injection, and low blood pressure.[1] Use in pregnancy may harm the baby.[1] It is in a class of drugs known as podophyllotoxin derivatives and is believed to work by interfering with the production of DNA.[1]
Teniposide was approved for medical use in the United States in 1992.[1] It has been sold in Europe since 1967 and Canada since 1984.[2][3] In the United States it costs about 2,100 USD per 50 mg dose as of 2021.[4] It is no longer commercially available in Canada.[3]
References
edit- ^ a b c d e f g h i j k "Teniposide Monograph for Professionals". Drugs.com. Archived from the original on 16 August 2019. Retrieved 25 September 2021.
- ^ a b Ravina, Enrique (18 April 2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. p. 156. ISBN 978-3-527-32669-3. Archived from the original on 25 September 2021. Retrieved 25 September 2021.
- ^ a b Government of Canada, Health Canada (25 April 2012). "Drug Product Database Online Query". health-products.canada.ca. Archived from the original on 27 September 2021. Retrieved 26 September 2021.
- ^ "Teniposide Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 25 September 2021.