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User:Mr. Ibrahem/Temazepam

< User:Mr. Ibrahem
Mr. Ibrahem/Temazepam
Clinical data
Trade namesRestoril, Normison, Nortem, others
AHFS/Drugs.comMonograph
MedlinePlusa684003
License data
Pregnancy
category
  • AU: C
Dependence
liability		High[1]
Routes of
administration		By mouth
Legal status
Legal status
Pharmacokinetic data
Bioavailability96%
MetabolismLiver
Elimination half-life8–20 hours
ExcretionKidney
Identifiers
  • 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-1,4-benzodiazepin-2-one
Chemical and physical data
FormulaC16H13ClN2O2
Molar mass300.74 g·mol−1
3D model (JSmol)
  • CN1C2=C(C(C3=CC=CC=C3)=NC(O)C1=O)C=C(Cl)C=C2
  • InChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3 checkY
  • Key:SEQDDYPDSLOBDC-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Temazepam, sold under the brand names Restoril among others, is a medication used to treat trouble sleeping.[3] Such use should generally be for less than ten days.[3] It is taken by mouth.[3] Effects generally begin within an hour and last for up to eight hours.[4]

Common side effects include sleepiness, anxiety, confusion, and dizziness.[3] Serious side effects may include hallucinations, abuse, anaphylaxis, and suicide.[3] Use is generally not recommended together with opioids.[3] If the dose is rapidly decreased withdrawal may occur.[3] Use during pregnancy or breastfeeding is not recommended.[5] Temazepam is an intermediate acting benzodiazepine and hypnotic.[3][4] It works by affecting GABA within the brain.[3]

Temazapam was patented in 1962 and came into medical use in 1969.[6] It is available as a generic medication.[7] A month supply in the United Kingdom costs the NHS about £1.40 as of 2019.[7] In the United States, the wholesale cost of this amount is about US$1.76.[8] In 2017, it was the 142nd most commonly prescribed medication in the United States, with more than four million prescriptions.[9][10]

References edit

  1. ^ "Temazepam". www.drugbank.ca. Archived from the original on 28 August 2019. Retrieved 26 June 2019.
  2. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 6 August 2020. Retrieved 8 September 2020.
  3. ^ a b c d e f g h i "Temazepam Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 29 December 2019. Retrieved 8 April 2019.
  4. ^ a b Collins, Shelly Rainforth; RN-BC, Shelly Rainforth Collins (2015). Pharmacology and the Nursing Process. Elsevier Health Sciences. p. 193. ISBN 9780323358286. Archived from the original on 2020-01-04. Retrieved 2019-04-08.
  5. ^ "Temazepam (Restoril) Use During Pregnancy". Drugs.com. Archived from the original on 29 August 2019. Retrieved 8 April 2019.
  6. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 537. ISBN 9783527607495. Archived from the original on 2020-01-02. Retrieved 2019-03-02.
  7. ^ a b British national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 481. ISBN 9780857113382.
  8. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  9. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  10. ^ "Temazepam - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
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