Wikipedia

User:Mr. Ibrahem/Telavancin

< User:Mr. Ibrahem
Mr. Ibrahem/Telavancin
Clinical data
Trade namesVibativ
AHFS/Drugs.comMonograph
MedlinePlusa610004
License data
Routes of
administration		Intravenous
Drug classLipoglycopeptide[1]
Legal status
Legal status
Pharmacokinetic data
BioavailabilityN/A
Protein binding90%, mostly to albumin
Elimination half-life9 hours
Excretion76% in urine, <1% in feces
Identifiers
  • (1S,2R,18R,19R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-5,15-dichloro-48-{[2-O-(3-{[2-(decylamino)ethyl]amino}-2,3,6-trideoxy-3-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy}-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-36-{[(phosphonomethyl)amino]methyl}-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
Chemical and physical data
FormulaC80H106Cl2N11O27P
Molar mass1755.65 g·mol−1
3D model (JSmol)
  • CCCCCCCCCCNCCN[C@]1(C[C@@H](O[C@H]([C@H]1O)C)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C(=C(C=C9[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)O)CNCP(=O)(O)O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)C
  • InChI=1S/C80H106Cl2N11O27P/c1-7-8-9-10-11-12-13-14-21-85-22-23-87-80(5)32-57(115-37(4)71(80)103)119-70-68(102)67(101)55(34-94)118-79(70)120-69-53-28-41-29-54(69)117-52-20-17-40(27-46(52)82)65(99)63-77(109)91-61(78(110)111)43-30-50(96)44(33-86-35-121(112,113)114)66(100)58(43)42-25-38(15-18-49(42)95)59(74(106)93-63)90-75(107)60(41)89-73(105)48(31-56(83)97)88-76(108)62(92-72(104)47(84-6)24-36(2)3)64(98)39-16-19-51(116-53)45(81)26-39/h15-20,25-30,36-37,47-48,55,57,59-65,67-68,70-71,79,84-87,94-96,98-103H,7-14,21-24,31-35H2,1-6H3,(H2,83,97)(H,88,108)(H,89,105)(H,90,107)(H,91,109)(H,92,104)(H,93,106)(H,110,111)(H2,112,113,114)/t37-,47+,48-,55+,57-,59+,60+,61-,62+,63-,64+,65+,67+,68-,70+,71+,79-,80-/m0/s1 checkY
  • Key:ONUMZHGUFYIKPM-MXNFEBESSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Telavancin, sold under the brand name Vibativ among others, is an antibiotics used to treat skin and skin structure infections (SSSI) and hospital acquired pneumonia.[1] This includes that due to MRSA.[1] It is given by injection into a vein.[1]

Common side effects include nausea, diarrhea, headache, trouble sleeping, and foamy urine.[1] Other side effects include kidney problems, red man syndrome, QT prolongation, and Clostridioides difficile infection.[1] Use during pregnancy may harm the baby.[1] It is a semi-synthetic lipoglycopeptide derived from vancomycin.[1] It works by stopping bacteria from forming a cell wall.[2]

Telavancin was approved for medical use in the United States in 2009.[1] While it was approved in Europe in 2011, this approval was subsequently withdrawn.[3] In the United States the medication costs about 570 USD per day as of 2021.[4]

References edit

  1. ^ a b c d e f g h i j k l "Telavancin Monograph for Professionals". Drugs.com. Archived from the original on 19 January 2021. Retrieved 25 September 2021.
  2. ^ "Vibativ" (PDF). Archived (PDF) from the original on 25 September 2021. Retrieved 25 September 2021.
  3. ^ "Vibativ". Archived from the original on 2 March 2021. Retrieved 25 September 2021.
  4. ^ "Vibativ Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 January 2021. Retrieved 25 September 2021.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Mr._Ibrahem/Telavancin&oldid=1220301892"