User:Mr. Ibrahem/Tazarotene

Mr. Ibrahem/Tazarotene
Clinical data
Trade names	Tazorac, Avage, Zorac, others
AHFS/Drugs.com	Monograph
Pregnancy; category	X (U.S.);
Routes of; administration	Topical
Drug class	Retinoid
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	>99%
Elimination half-life	19 Hours
Identifiers
	IUPAC name ethyl 6-[2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]pyridine-3-carboxylate;
Chemical and physical data
Formula	C21H21NO2S
Molar mass	351.46 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)c1ccc(nc1)C#Cc3ccc2SCCC(c2c3)(C)C;
	InChI InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3 ; Key:OGQICQVSFDPSEI-UHFFFAOYSA-N ;
	(verify)

Tazarotene, sold under the brand name Tazorac among others, is a medication primarily used to treat plaque psoriasis and acne.^[1] It is also used for photoaged skin.^[1] It is applied to the skin.^[1]

Common side effects include skin redness, peeling, itchiness, and skin pain.^[1] Other side effects include an increase risk of a sunburn.^[1] Use in pregnancy may harm the baby while use during breastfeeding appear okay.^[1]^[2] It is a third-generation retinoid of the acetylenic class.^[3]^[1]

Tazarotene was approved for medical use in 1997.^[1] It is available as a generic medication.^[4] In the United States a 30 gram tube of 0.1% costs about 70 USD as of 2021.^[4] This amount in the United Kingdom costs the NHS about 15 pounds.^[5] It is also available in some other European countries as of 2021.^[2]

References

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Tazarotene Monograph for Professionals". Drugs.com. Archived from the original on January 22, 2021. Retrieved September 24, 2021.
^ ^a ^b "Tazarotene". SPS - Specialist Pharmacy Service. April 28, 2015. Archived from the original on September 24, 2021. Retrieved September 24, 2021.
^ Thielitz A, Abdel-Naser MB, Fluhr JW, Zouboulis CC, Gollnick H (December 2008). "Topical retinoids in acne--an evidence-based overview". J Dtsch Dermatol Ges. 6 (12): 1023–31. doi:10.1111/j.1610-0387.2008.06741.x. PMID 18479477.
^ ^a ^b "Tazarotene Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved September 24, 2021.
^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1330. ISBN 978-0-85711-369-6.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Tazarotene Monograph for Professionals". Drugs.com. Archived from the original on January 22, 2021. Retrieved September 24, 2021.

[SPS2021-2] "Tazarotene". SPS - Specialist Pharmacy Service. April 28, 2015. Archived from the original on September 24, 2021. Retrieved September 24, 2021.

[Thi2008-3] Thielitz A, Abdel-Naser MB, Fluhr JW, Zouboulis CC, Gollnick H (December 2008). "Topical retinoids in acne--an evidence-based overview". J Dtsch Dermatol Ges. 6 (12): 1023–31. doi:10.1111/j.1610-0387.2008.06741.x. PMID 18479477.

[GX2021-4] "Tazarotene Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved September 24, 2021.

[BNF80-5] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1330. ISBN 978-0-85711-369-6.

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