Clinical data | |
---|---|
Trade names | Xpovio, Nexpovio |
Other names | KPT-330 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a619044 |
License data | |
Pregnancy category |
|
Routes of administration | By mouth |
Drug class | Inhibitor of nuclear export[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 95% |
Metabolism | Liver oxidation, glucuronidation, and conjugation, by CYP3A4, UGT and GST |
Elimination half-life | 6–8 hours |
Identifiers | |
| |
Chemical and physical data | |
Formula | C17H11F6N7O |
Molar mass | 443.313 g·mol−1 |
3D model (JSmol) | |
|
Selinexor sold under the brand name Xpovio among others, is a medication used to treat multiple myeloma.[3] It is used in cases were at least 4 other treatments have been found ineffective.[3] It is taken by mouth together with dexamethasone.[3][1]
Common side effects include nausea, weight loss, diarrhea, tiredness, low platelets, low red blood cells, low white blood cells, and low sodium.[1] Other side effects may include syncope.[3] Use during pregnancy may harm the baby.[3] It is a inhibitor of nuclear export and works by blocking the action of exportin 1.[1]
Selinexor was approved for medical use in the United States in 2019 and Europe in 2021.[3][1] In the United States it costs about 24,000 USD every 4 weeks.[4] While approved in the United Kingdom, it is not available there as of 2021.[5]
References
edit- ^ a b c d e f g "Nexpovio EPAR". European Medicines Agency (EMA). 25 January 2021. Archived from the original on 2 June 2021. Retrieved 27 May 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ "Xpovio- selinexor tablet, film coated". DailyMed. 19 August 2019. Archived from the original on 29 August 2021. Retrieved 20 November 2019.
- ^ a b c d e f g h "Selinexor Monograph for Professionals". Drugs.com. Archived from the original on 14 August 2020. Retrieved 12 October 2021.
- ^ "Xpovio Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 23 April 2021. Retrieved 12 October 2021.
- ^ "Selinexor". SPS - Specialist Pharmacy Service. 19 June 2017. Archived from the original on 13 October 2021. Retrieved 12 October 2021.