 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Istodax |
| Other names | FK228; FR901228; Istodax |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a610005 |
| License data |
|
| Routes of administration | Intravenous infusion |
| Drug class | Histone deacetylase inhibitor[1] |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | Not applicable (IV only) |
| Protein binding | 92–94% |
| Metabolism | Liver (mostly CYP3A4-mediated) |
| Elimination half-life | 3 hours |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C24H36N4O6S2 |
| Molar mass | 540.69 g·mol−1 |
| 3D model (JSmol) | |
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Romidepsin, sold under the brand name Istodax, is a medication used to treat cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphomas (PTCLs).[2] It is used after other treatments have failed.[2] It is given by gradual injection into a vein.[3]
Common side effects include low white blood cells, low platelets, nausea, tiredness, and infection.[2] Other side effects may include tumor lysis syndrome and QT prolongation.[3][2] Use during pregnancy may harm the baby.[2] It works by blocking an enzyme known as histone deacetylases, bringing about programmed cell death.[1]
Romidepsin was approved for medical use in the United States in 2009.[3] It was refused approval in Europe in 2012.[4] It is obtained from the bacterium Chromobacterium violaceum.[3] In the United States it costs about 3,350 USD per 10 mg dose.[5] A generic version was approved in 2021 in the USA.[6]
References edit
- ^ a b "Romidepsin". National Cancer Institute. Archived from the original on 2009-05-09. Retrieved 2009-09-11.
- ^ a b c d e f g "DailyMed - ROMIDEPSIN injection, solution, concentrate". dailymed.nlm.nih.gov. Archived from the original on 18 October 2021. Retrieved 18 October 2021.
- ^ a b c d "Romidepsin Monograph for Professionals". Drugs.com. Archived from the original on 7 March 2016. Retrieved 18 October 2021.
- ^ "Istodax". Archived from the original on 3 December 2020. Retrieved 18 October 2021.
- ^ "Istodax Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 22 January 2021. Retrieved 18 October 2021.
- ^ Research, Center for Drug Evaluation and (10 February 2022). "2021 First Generic Drug Approvals". FDA. Archived from the original on 21 June 2022. Retrieved 22 October 2022.