 | |
| Clinical data | |
|---|---|
| Trade names | Esbriet, Pirespa, Etuary, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a615008 |
| License data |
|
| Routes of administration | By mouth |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 50–58%[1] |
| Metabolism | Hepatic (70–80% CYP1A2-mediated; minor contributions from CYP2C9, CYP2C19, CYP2D6 and CYP2E1)[1] |
| Elimination half-life | 2.4 hours[1] |
| Excretion | Urine (80%)[1] |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C12H11NO |
| Molar mass | 185.226 g·mol−1 |
| 3D model (JSmol) | |
| Solubility in water | 10mg/mL at 60 °C |
| |
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Pirfenidone, sold under the brand name Pirespa among others, is a medication used to treat idiopathic pulmonary fibrosis.[2] It is used for mild to moderate disease.[4] It is taken by mouth.[2]
Common side effects include nausea, rash, tiredness, heartburn, headache, and sunburns.[2] Other side effects may include liver problems.[3] Safety in pregnancy is not clear.[5] How it works is not entire clear, however it reduces the production of fibroblasts.[2]
Pirfenidone was approved for medical use in Europe in 2011 and the United States in 2014.[2][3] In the United Kingdom 4 weeks of medication costs the NHS about £2,000 as of 2021.[4] In the United States this amount is about 9,900 USD.[6]
References
edit- ^ a b c d "Esbriet 267 mg hard capsules". electronic Medicines Compendium. Intermune UK & I Ltd. 3 January 2014. Archived from the original on 12 October 2013. Retrieved 6 March 2014.
- ^ a b c d e f g "Esbriet". Archived from the original on 24 November 2020. Retrieved 28 October 2021.
- ^ a b c "Pirfenidone Monograph for Professionals". Drugs.com. Archived from the original on 21 June 2020. Retrieved 28 October 2021.
- ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 314. ISBN 978-0857114105.
- ^ "Pirfenidone (Esbriet) Use During Pregnancy". Drugs.com. Archived from the original on 27 January 2021. Retrieved 28 October 2021.
- ^ "Esbriet Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 28 January 2021. Retrieved 28 October 2021.