User:Mr. Ibrahem/Phentolamine

Mr. Ibrahem/Phentolamine
Clinical data
Trade names	Regitine, Oraverse
AHFS/Drugs.com	Monograph
Routes of; administration	intravenous (IV) or intramuscular (IM)
Drug class	Alpha blocker
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Metabolism	Liver
Onset of action	IV < 2min; IM < 20 min
Elimination half-life	19 minutes
Duration of action	IV up to 30 min; IM up to 4 hrs
Identifiers
	IUPAC name 3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol;
Chemical and physical data
Formula	C17H19N3O
Molar mass	281.359 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc3cc(N(c1ccc(cc1)C)CC/2=N/CCN\2)ccc3;
	InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) ; Key:MRBDMNSDAVCSSF-UHFFFAOYSA-N ;
	(what is this?) (verify)

Phentolamine, sold under the brand name Regitine among others, is a medication used to treat high blood pressure in pheochromocytoma, following norepinephrine entry into soft tissues, and hypertensive emergencies.^[1]^[2] It is given by injection.^[1] When injected into a vein effects occur within 2 minutes and last up to 30 minutes.^[1]

Common side effects include abdominal pain, nausea, diarrhea, flushing, stuffy nose, and low blood pressure with standing.^[1] Other side effects may include myocardial infarction and priapism.^[1] Safety in pregnancy is unclear.^[3] It is a alpha blocker.^[1]

Phentolamine was approved for medical use in the United States in 1952.^[1] In the United States it costs about 460 USD per dose as of 2021.^[4] In the United Kingdom it is available together with aviptadil for the treatment of erectile dysfunction.^[5]

References edit

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m "Phentolamine Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 28 October 2021.
^ ^a ^b "DailyMed - PHENTOLAMINE MESYLATE injection". dailymed.nlm.nih.gov. Archived from the original on 28 October 2021. Retrieved 28 October 2021.
^ "Phentolamine Use During Pregnancy". Drugs.com. Archived from the original on 27 October 2020. Retrieved 28 October 2021.
^ "Phentolamine Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 28 October 2021.
^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 866. ISBN 978-0857114105.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m "Phentolamine Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 28 October 2021.

[PI2021-2] "DailyMed - PHENTOLAMINE MESYLATE injection". dailymed.nlm.nih.gov. Archived from the original on 28 October 2021. Retrieved 28 October 2021.

[3] "Phentolamine Use During Pregnancy". Drugs.com. Archived from the original on 27 October 2020. Retrieved 28 October 2021.

[4] "Phentolamine Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 28 October 2021.

[BNF81-5] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 866. ISBN 978-0857114105.

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