User:Mr. Ibrahem/Perindopril

Mr. Ibrahem/Perindopril
Clinical data
Pronunciation	per-in-do-pril
Trade names	Coversyl, Coversum, Aceon, others
AHFS/Drugs.com	Monograph
Routes of; administration	By mouth
Drug class	ACE inhibitor
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	24%
Protein binding	20%
Metabolism	Renal
Elimination half-life	1–17 hours for perindoprilat (active metabolite)
Identifiers
	IUPAC name (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid;
Chemical and physical data
Formula	C19H32N2O5
Molar mass	368.474 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)[C@@H](N[C@H](C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@H]12)C)CCC;
	InChI InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1 ; Key:IPVQLZZIHOAWMC-QXKUPLGCSA-N ;
	(what is this?) (verify)

Perindopril is a medication used to treat high blood pressure, heart failure, diabetic kidney disease, and coronary artery disease.^[1]^[3] It is taken by mouth.^[2] Maximum effect occurs over several weeks.^[1]

Common side effects include cough, palpitations, muscle cramps, and protein in the urine.^[1]^[2] Other side effects may include angioedema, low blood pressure, and kidney failure.^[1] Use during pregnancy may harm the baby.^[1] A lower dose should be used in those with kidney problems.^[2] It is an ACE inhibitor and works by inhibiting the renin-angiotensin-aldosterone system.^[1]

Perindopril was patented in 1980 and approved for medical use in 1988.^[4] It is available as a generic medication.^[5] In the United Kingdom a month of medication costs the NHS about 7 pounds.^[2] In the United States this amount costs about 15 USD as of 2021.^[5] It is available as perindopril erbumine and perindopril arginine.^[1]

References edit

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Perindopril Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 18 July 2021.
^ ^a ^b ^c ^d ^e ^f BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 182. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ "Consumer Medicine Information, GenRx Perindopril" (PDF). Clinical Resources, Medicine information for health professionals. Royal Australian College of General Practitioners. Archived from the original (PDF) on 2007-09-01.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 467. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2020-05-12.
^ ^a ^b "Perindopril Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 18 July 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "Perindopril Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 18 July 2021.

[BNF80-2] ^ ^a ^b ^c ^d ^e ^f BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 182. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[Au2007-3] "Consumer Medicine Information, GenRx Perindopril" (PDF). Clinical Resources, Medicine information for health professionals. Royal Australian College of General Practitioners. Archived from the original (PDF) on 2007-09-01.

[Fis2006-4] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 467. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2020-05-12.

[GX2021-5] "Perindopril Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 18 July 2021.

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