User:Mr. Ibrahem/Ospemifene

Mr. Ibrahem/Ospemifene
Clinical data
Trade names	Osphena; Senshio
Other names	Deaminohydroxytoremifene
AHFS/Drugs.com	Monograph
License data	EU EMA: by INN; US FDA: Ospemifene;
Pregnancy; category	EU: X;
Routes of; administration	By mouth
Drug class	Selective estrogen receptor modulator
Legal status
Legal status	US: Rx-only; EU = Rx-only;
Identifiers
	IUPAC name 2-(p-((Z)-4-chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol;
Chemical and physical data
Formula	C24H23ClO2
Molar mass	378.90 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClCC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(C=C3)OCCO;
	InChI InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-; Key:LUMKNAVTFCDUIE-VHXPQNKSSA-N;

Ospemifene, sold under the brand names Osphena and Senshio, is a medication used to treat vaginal atrophy in women after menopause.^[1] It is used when estrogen cannot be applied.^[1] It is taken by mouth.^[1]

Common side effects include vaginal candidiasis, hot flushes, headache, muscle spasms, rash, and vaginal bleeding.^[1] It should not be used in people with breast cancer or venous thromboembolism.^[2] It is a selective estrogen receptor modulator (SERM).^[1] It acts similarly to estrogen on the vagina.^[1]

Ospemifene was approved for medical use in the United States in 2013 and Europe in 2015.^[3]^[1] In the United Kingdom 4 weeks of treatment costs the NHS about £40.^[2] This amount in the United States is about 210 USD.^[4]

References

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "European Medicines Agency". Archived from the original on 2021-05-21. Retrieved 2021-10-16.
^ ^a ^b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 880. ISBN 978-0857114105.
^ "Ospemifene Monograph for Professionals". Drugs.com. Archived from the original on 24 August 2019. Retrieved 9 November 2021.
^ "Ospemifene Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 10 November 2021.

[EPAR2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "European Medicines Agency". Archived from the original on 2021-05-21. Retrieved 2021-10-16.

[BNF81-2] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 880. ISBN 978-0857114105.

[AHFS2021-3] "Ospemifene Monograph for Professionals". Drugs.com. Archived from the original on 24 August 2019. Retrieved 9 November 2021.

[4] "Ospemifene Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 10 November 2021.

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