Clinical data | |
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Trade names | Symproic, Rizmoic |
Other names | S-297,995 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a617031 |
License data |
|
Routes of administration | By mouth |
Drug class | Peripherally acting μ-opioid receptor antagonist[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | 93–94% |
Metabolism | primarily CYP3A4 |
Elimination half-life | 11 hrs |
Excretion | Urine, feces |
Identifiers | |
| |
Chemical and physical data | |
Formula | C32H34N4O6 |
Molar mass | 570.646 g·mol−1 |
3D model (JSmol) | |
| |
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Naldemedine, sold under the brand name Symproic and Rizmoic, is a medication used to treat opioid-induced constipation in chronic non-cancer pain.[1] It may be used when laxatives are not effective.[2] It is taken by mouth.[1]
Common side effects include abdominal pain, nausea, and diarrhea.[1] Other side effects may include gastrointestinal perforation, allergic reactions, and opioid withdrawal.[1] Safety in pregnancy is unclear.[3] It is a peripherally acting μ-opioid receptor antagonist, which prevents opioids from binding to receptors in the gut.[1][2] It generally dose not affect pain management.[4]
Naldemedine was approved for medical use in the United States in 2017 and Europe in 2019.[1][2] In the United States it costs about 330 USD per month as of 2021.[5] In the United Kingdom this amount costs about £42.[4]
References
edit- ^ a b c d e f g h i j "Naldemedine Monograph for Professionals". Drugs.com. Archived from the original on 8 June 2021. Retrieved 11 November 2021.
- ^ a b c "Rizmoic". Archived from the original on 29 December 2019. Retrieved 11 November 2021.
- ^ "Naldemedine (Symproic) Use During Pregnancy". Drugs.com. Archived from the original on 27 October 2020. Retrieved 11 November 2021.
- ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 70. ISBN 978-0857114105.
- ^ "Symproic Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 15 November 2021. Retrieved 11 November 2021.