Clinical data | |
---|---|
Trade names | Mitosol, Mutamycin, Jelmyto, others |
Other names | Mitomycin, UGN-101 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682415 |
License data | |
Pregnancy category |
|
Routes of administration | Intravenous, topical |
Drug class | Antineoplastic agent |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Metabolism | Liver |
Elimination half-life | 8–48 min |
Identifiers | |
| |
Chemical and physical data | |
Formula | C15H18N4O5 |
Molar mass | 334.332 g·mol−1 |
3D model (JSmol) | |
Melting point | 360 °C (680 °F) |
Solubility in water | 8.43 g L−1 |
| |
|
Mitomycin C, sold under the brand name Mutamycin among others, is a medication used to treat cancer including bladder cancer, breast cancer, pancreatic cancer, and non-small cell lung cancer (NSCLC).[3] It is given by injection into a vein.[4]
Common side effects include bone marrow suppression, cough, bleeding, tiredness, nausea, rash, and low platelets.[3] Other side effects may include hair loss, fever, hemolytic uremic syndrome, and liver problems.[3][4] Use in pregnancy may harm the baby.[3] It is in the family of mitomycins.[5]
Mitomycin C was isolated in 1958.[5] It is available as a generic medication. In the United Kingdom 40 mg costs the NHS about £76 as of 2021.[3] This amount in the United States costs about 430 USD.[6] It is made by Streptomyces caespitosus.[4]
References
edit- ^ "KUWQIF: Mitomycin C Dihydrate, also known as (6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate dihydrate". Cambridge Structural Database: Access Structures. Cambridge Crystallographic Data Centre. doi:10.5517/ccv38nv. Archived from the original on 19 November 2021. Retrieved 2021-11-03.
- ^ a b "Mitomycin (Mutamycin) Use During Pregnancy". Drugs.com. 19 August 2019. Archived from the original on 22 October 2020. Retrieved 15 April 2020.
- ^ a b c d e f g BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 964. ISBN 978-0857114105.
- ^ a b c "Mitomycin Monograph for Professionals". Drugs.com. Archived from the original on 6 March 2021. Retrieved 18 November 2021.
- ^ a b Advances in Molecular Toxicology. Elsevier. 6 December 2012. p. 244. ISBN 978-0-444-59402-0. Archived from the original on 19 November 2021. Retrieved 18 November 2021.
- ^ "Mitomycin Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 12 August 2020. Retrieved 18 November 2021.