User:Mr. Ibrahem/Milnacipran

Mr. Ibrahem/Milnacipran
	Top: (1S,2R)-milnacipran (L-milnacipran); Bottom: (1R,2S)-milnacipran (D-milnacipran)
Clinical data
Trade names	Ixel, Joncia, Savella, Dalcipran, others
Other names	Milnacipran hydrochloride
AHFS/Drugs.com	Monograph
MedlinePlus	a609016
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth (tablets), capsules)
Drug class	Serotonin–norepinephrine reuptake inhibitor (SNRI)
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	85%
Protein binding	13%
Metabolism	Liver
Elimination half-life	8 hours
Excretion	Kidney
Identifiers
	IUPAC name (±)-(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1- phenylcyclopropane-1-carboxamide;
Chemical and physical data
Formula	C15H22N2O
Molar mass	246.354 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C(N(CC)CC)[C@@]2(c1ccccc1)[C@@H](CN)C2;
	InChI InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m1/s1 ; Key:GJJFMKBJSRMPLA-HIFRSBDPSA-N ;
	(verify)

Milnacipran, sold under the brand name Savella among others, is a medication used to treat fibromyalgia and major depressive disorder.^[1] It is taken by mouth.^[1]

Common side effects include nausea, headache, trouble sleeping, increased sweating, and palpitations.^[1] Other side effects may include suicide in those under 25 years old, serotonin syndrome, increased blood pressure, liver problems, bleeding, and mania.^[1] Safety in pregnancy is unclear.^[1] It is a serotonin–norepinephrine reuptake inhibitor (SNRI).^[1]

Milnacipran was approved for medical use in the United States in 2009.^[1] It was denied approval in Europe in 2009 due to questionable benefits.^[2] In the United States it costs about 420 USD for a month as of 2021.^[3]

References edit

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Milnacipran Monograph for Professionals". Drugs.com. Archived from the original on 27 February 2021. Retrieved 18 November 2021.
^ "Milnacipran Pierre Fabre Medicament". Archived from the original on 22 September 2020. Retrieved 18 November 2021.
^ "Savella Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 17 August 2021. Retrieved 18 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Milnacipran Monograph for Professionals". Drugs.com. Archived from the original on 27 February 2021. Retrieved 18 November 2021.

[2] "Milnacipran Pierre Fabre Medicament". Archived from the original on 22 September 2020. Retrieved 18 November 2021.

[3] "Savella Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 17 August 2021. Retrieved 18 November 2021.

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